Gene description for OSGEP
Gene name O-sialoglycoprotein endopeptidase
Gene symbol OSGEP
Other names/aliases GCPL1
KAE1
OSGEP1
PRSMG1
Species Homo sapiens
 Database cross references - OSGEP
ExoCarta ExoCarta_55644
Entrez Gene 55644
HGNC 18028
MIM 610107
UniProt Q9NPF4  
 OSGEP identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for OSGEP
Molecular Function
    transferase activity, transferring acyl groups GO:0016746 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    threonylcarbamoyladenosine biosynthetic process GO:0070526 IBA
Subcellular Localization
    EKC/KEOPS complex GO:0000408 IBA
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified OSGEP in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OSGEP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJA1 3301
Affinity Capture-MS Homo sapiens
2 GP1BA 2811
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
3 MUC1 4582
Invitro Homo sapiens
4 RAB5C 5878
Affinity Capture-MS Homo sapiens
5 EMCN  
Invitro Homo sapiens
6 OPTC  
Invitro Homo sapiens
7 DXS9879E  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which OSGEP is involved
No pathways found





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