Gene description for COMMD8
Gene name COMM domain containing 8
Gene symbol COMMD8
Other names/aliases -
Species Homo sapiens
 Database cross references - COMMD8
ExoCarta ExoCarta_54951
Vesiclepedia VP_54951
Entrez Gene 54951
HGNC 26036
UniProt Q9NX08  
 COMMD8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for COMMD8
Molecular Function
    protein binding GO:0005515 IPI
    NF-kappaB binding GO:0051059 IBA
Biological Process
    signal transduction GO:0007165 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified COMMD8 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COMMD8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COMMD10 51397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
2 RELA 5970
Affinity Capture-Western Homo sapiens
3 CCDC151  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 AKR1C1 1645
Two-hybrid Homo sapiens
5 UIMC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CNGA4  
Affinity Capture-MS Homo sapiens
7 FAM45A 404636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 OR13G1  
Affinity Capture-MS Homo sapiens
9 Ranbp1 19385
Affinity Capture-MS Mus musculus
10 CTAGE5 4253
Affinity Capture-MS Homo sapiens
11 FAM167A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 STMN2  
Affinity Capture-MS Homo sapiens
13 CCDC114  
Affinity Capture-MS Homo sapiens
14 C15orf59  
Affinity Capture-MS Homo sapiens
15 IKBIP 121457
Affinity Capture-MS Homo sapiens
16 TFDP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 COMMD5 28991
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ZNF268  
Affinity Capture-MS Homo sapiens
19 NUP62 23636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 COG4 25839
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 COMMD7 149951
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ATP6V1D 51382
Co-fractionation Homo sapiens
23 MAPK3 5595
Co-fractionation Homo sapiens
24 COMMD2 51122
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 DSCR3 10311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SQSTM1 8878
Proximity Label-MS Homo sapiens
27 COG7 91949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 QSER1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 BOLA1 51027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CNKSR3 154043
Affinity Capture-MS Homo sapiens
31 CCDC93 54520
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 VPS29 51699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 COG6 57511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 COG1 9382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 COG2 22796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 E2F6 1876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 C16orf62 57020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 TFDP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PSPC1 55269
Affinity Capture-MS Homo sapiens
41 BAG1 573
Affinity Capture-MS Homo sapiens
42 ATP9A 10079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 COG8 84342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 COMMD6 170622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 RELB  
Affinity Capture-Western Homo sapiens
46 COMMD9 29099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 NFKB1 4790
Affinity Capture-Western Homo sapiens
48 COG3 83548
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ACTR1A 10121
Proximity Label-MS Homo sapiens
50 TRIM72  
Affinity Capture-MS Homo sapiens
51 CCDC22 28952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 COG5 10466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 COMMD4 54939
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 ZNF474  
Two-hybrid Homo sapiens
55 COMMD3 23412
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 KIF2B 84643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 TMX2 51075
Two-hybrid Homo sapiens
58 COMMD1 150684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which COMMD8 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





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