Gene description for LRRC40
Gene name leucine rich repeat containing 40
Gene symbol LRRC40
Other names/aliases dJ677H15.1
Species Homo sapiens
 Database cross references - LRRC40
ExoCarta ExoCarta_55631
Vesiclepedia VP_55631
Entrez Gene 55631
HGNC 26004
UniProt Q9H9A6  
 LRRC40 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LRRC40
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    intracellular signal transduction GO:0035556 IBA
Subcellular Localization
    membrane GO:0016020 HDA
 Experiment description of studies that identified LRRC40 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LRRC40
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SUGT1 10910
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
3 PGK2 5232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 HSPA2 3306
Affinity Capture-MS Homo sapiens
6 SCRIB 23513
Affinity Capture-MS Homo sapiens
7 BKRF1  
Affinity Capture-MS
8 SPSB4  
Affinity Capture-MS Homo sapiens
9 AMTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MTPN 136319
Affinity Capture-MS Homo sapiens
11 BAG1 573
Affinity Capture-MS Homo sapiens
12 LUM 4060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EGLN3  
Affinity Capture-MS Homo sapiens
14 TBC1D4  
Affinity Capture-MS Homo sapiens
15 LRRC23  
Affinity Capture-MS Homo sapiens
16 APOO 79135
Proximity Label-MS Homo sapiens
17 SKP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 BAG2 9532
Affinity Capture-MS Homo sapiens
19 LRRC57 255252
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 FAM184A 79632
Affinity Capture-MS Homo sapiens
21 EGFR 1956
Affinity Capture-MS Homo sapiens
22 CNPY3 10695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 BPNT1 10380
Co-fractionation Homo sapiens
24 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 MEPCE 56257
Affinity Capture-MS Homo sapiens
26 MRI1 84245
Co-fractionation Homo sapiens
27 IQCF1  
Affinity Capture-MS Homo sapiens
28 JAZF1  
Affinity Capture-MS Homo sapiens
29 LRRC27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 C9orf78 51759
Affinity Capture-MS Homo sapiens
31 FKBP5 2289
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
32 PRMT6  
Affinity Capture-MS Homo sapiens
33 GP5 2814
Affinity Capture-MS Homo sapiens
34 EZH2  
Affinity Capture-MS Homo sapiens
35 USP47 55031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LRIG1 26018
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 GTF2E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 NTRK1 4914
Affinity Capture-MS Homo sapiens
39 TLR3  
Affinity Capture-MS Homo sapiens
40 RPL35A 6165
Affinity Capture-MS Homo sapiens
41 HSPA1A 3303
Affinity Capture-MS Homo sapiens
42 ZNF215  
Affinity Capture-MS Homo sapiens
43 C9orf3 84909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SNW1 22938
Affinity Capture-MS Homo sapiens
45 KERA  
Affinity Capture-MS Homo sapiens
46 PARK2  
Affinity Capture-MS Homo sapiens
47 CNOT6L 246175
Affinity Capture-MS Homo sapiens
48 ISLR 3671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 VASN 114990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 FSCN1 6624
Affinity Capture-MS Homo sapiens
51 KCTD3  
Co-fractionation Homo sapiens
52 TIMP2 7077
Co-fractionation Homo sapiens
53 CCDC8  
Affinity Capture-MS Homo sapiens
54 CDC5L 988
Affinity Capture-MS Homo sapiens
55 RUFY1 80230
Affinity Capture-MS Homo sapiens
56 RPA3 6119
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRC40 is involved
No pathways found





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