Gene description for TXNDC9
Gene name thioredoxin domain containing 9
Gene symbol TXNDC9
Other names/aliases APACD
PHLP3
Species Homo sapiens
 Database cross references - TXNDC9
ExoCarta ExoCarta_10190
Vesiclepedia VP_10190
Entrez Gene 10190
HGNC 24110
MIM 612564
UniProt O14530  
 TXNDC9 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TXNDC9
Molecular Function
    protein binding GO:0005515 IPI
    cadherin binding GO:0045296 HDA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    midbody GO:0030496 IEA
 Experiment description of studies that identified TXNDC9 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TXNDC9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHIC1  
Affinity Capture-MS Homo sapiens
2 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CLRN3 119467
Affinity Capture-MS Homo sapiens
4 PCF11 51585
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
5 SCNM1  
Affinity Capture-MS Homo sapiens
6 ZPR1 8882
Co-fractionation Homo sapiens
7 CCT4 10575
Affinity Capture-MS Homo sapiens
8 SLC25A48  
Affinity Capture-MS Homo sapiens
9 CCT6B 10693
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
10 SETDB1  
Two-hybrid Homo sapiens
11 Cct2 12461
Affinity Capture-MS Mus musculus
12 TCEAL3  
Co-fractionation Homo sapiens
13 CCDC43 124808
Affinity Capture-MS Homo sapiens
14 FBXW4 6468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 WDR86  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PBX4  
Two-hybrid Homo sapiens
17 SPAG9 9043
Co-fractionation Homo sapiens
18 C8orf82  
Proximity Label-MS Homo sapiens
19 MRPL12 6182
Two-hybrid Homo sapiens
20 ACTR1A 10121
Proximity Label-MS Homo sapiens
21 PRDX2 7001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 C3orf62  
Two-hybrid Homo sapiens
23 MED22  
Two-hybrid Homo sapiens
24 TUBA3C 7278
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 VPS53 55275
Co-fractionation Homo sapiens
26 Cct4 12464
Affinity Capture-MS Mus musculus
27 CHD3 1107
Two-hybrid Homo sapiens
28 FBXW5  
Affinity Capture-MS Homo sapiens
29 TEX9  
Two-hybrid Homo sapiens
30 PEX7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 LSM2 57819
Co-fractionation Homo sapiens
32 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CCDC172  
Two-hybrid Homo sapiens
34 TCP1 6950
Affinity Capture-MS Homo sapiens
35 SAMM50 25813
Proximity Label-MS Homo sapiens
36 WASF1 8936
Co-fractionation Homo sapiens
37 SAE1 10055
Co-fractionation Homo sapiens
38 PIAS4  
Affinity Capture-MS Homo sapiens
39 RRP9 9136
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
40 Cct7 12468
Affinity Capture-MS Mus musculus
41 TUBA1A 7846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CCT5 22948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 MPPED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 POC1A  
Affinity Capture-MS Homo sapiens
45 CDH1 999
Proximity Label-MS Homo sapiens
46 TUBA1C 84790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ZNF655  
Two-hybrid Homo sapiens
48 DYDC1  
Two-hybrid Homo sapiens
49 YWHAQ 10971
Co-fractionation Homo sapiens
50 TUBA1B 10376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CEP76  
Two-hybrid Homo sapiens
52 RASL10B  
Affinity Capture-MS Homo sapiens
53 COG4 25839
Two-hybrid Homo sapiens
54 C17orf102  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 ZCCHC8 55596
Co-fractionation Homo sapiens
56 PTN  
Two-hybrid Homo sapiens
57 Cct3 12462
Affinity Capture-MS Mus musculus
58 EGLN3  
Affinity Capture-MS Homo sapiens
59 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 MYOG  
Two-hybrid Homo sapiens
61 TUBAL3 79861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 NUDT21 11051
Co-fractionation Homo sapiens
63 UBR7  
Co-fractionation Homo sapiens
64 TUBB4B 10383
Affinity Capture-MS Homo sapiens
65 PGAM4 441531
Affinity Capture-MS Homo sapiens
66 Csde1 229663
Affinity Capture-MS Mus musculus
67 KIAA1377  
Two-hybrid Homo sapiens
68 NUP214 8021
Co-fractionation Homo sapiens
69 ARFIP1 27236
Co-fractionation Homo sapiens
70 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 BAG1 573
Co-fractionation Homo sapiens
72 GNB2 2783
Affinity Capture-MS Homo sapiens
73 TRIM27  
Two-hybrid Homo sapiens
74 C1orf94  
Two-hybrid Homo sapiens
75 Cct8 12469
Affinity Capture-MS Mus musculus
76 MAGEA6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
77 GIT1 28964
Two-hybrid Homo sapiens
78 HUWE1 10075
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
79 IMMT 10989
Two-hybrid Homo sapiens
80 TUBB2A 7280
Affinity Capture-MS Homo sapiens
81 IKBKAP 8518
Two-hybrid Homo sapiens
82 FEZ1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
83 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
84 FAM175B 23172
Co-fractionation Homo sapiens
85 PDCL3 79031
Affinity Capture-MS Homo sapiens
86 CPSF6 11052
Co-fractionation Homo sapiens
87 PPIP5K1 9677
Co-fractionation Homo sapiens
88 TUBG2  
Affinity Capture-MS Homo sapiens
89 PNPLA1 285848
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PNMA1 9240
Two-hybrid Homo sapiens
91 MAGEA9  
Affinity Capture-MS Homo sapiens
92 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 Tuba3a 22144
Affinity Capture-MS Mus musculus
94 KLHDC8A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 SMYD2 56950
Affinity Capture-MS Homo sapiens
96 C4orf26  
Affinity Capture-MS Homo sapiens
97 ZCCHC10  
Affinity Capture-MS Homo sapiens
98 FBXW9  
Affinity Capture-MS Homo sapiens
99 SERBP1 26135
Affinity Capture-MS Homo sapiens
100 KLF11  
Two-hybrid Homo sapiens
101 WDHD1  
Co-fractionation Homo sapiens
102 EXOSC8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TXNDC9 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here