Gene description for ATM
Gene name ATM serine/threonine kinase
Gene symbol ATM
Other names/aliases AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
Species Homo sapiens
 Database cross references - ATM
ExoCarta ExoCarta_472
Vesiclepedia VP_472
Entrez Gene 472
HGNC 795
MIM 607585
UniProt Q13315  
 ATM identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ATM
Molecular Function
    DNA binding GO:0003677 IEA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IDA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    1-phosphatidylinositol-3-kinase activity GO:0016303 IMP
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 ISS
    identical protein binding GO:0042802 IPI
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    protein-containing complex binding GO:0044877 IDA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    DNA damage checkpoint signaling GO:0000077 IBA
    DNA damage checkpoint signaling GO:0000077 IDA
    pexophagy GO:0000425 IDA
    telomere maintenance GO:0000723 IBA
    double-strand break repair via homologous recombination GO:0000724 IDA
    DNA double-strand break processing GO:0000729 IDA
    ovarian follicle development GO:0001541 IEA
    response to hypoxia GO:0001666 IEA
    somitogenesis GO:0001756 IEA
    pre-B cell allelic exclusion GO:0002331 ISS
    double-strand break repair GO:0006302 IBA
    double-strand break repair GO:0006302 IDA
    double-strand break repair GO:0006302 TAS
    double-strand break repair via nonhomologous end joining GO:0006303 TAS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 IMP
    DNA damage response GO:0006974 IDA
    DNA damage response GO:0006974 IMP
    DNA damage response GO:0006974 IMP
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS
    mitotic spindle assembly checkpoint signaling GO:0007094 IMP
    mitotic G2 DNA damage checkpoint signaling GO:0007095 IMP
    reciprocal meiotic recombination GO:0007131 TAS
    male meiotic nuclear division GO:0007140 IEA
    female meiotic nuclear division GO:0007143 IEA
    signal transduction GO:0007165 TAS
    brain development GO:0007420 IEA
    heart development GO:0007507 IEA
    determination of adult lifespan GO:0008340 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IBA
    post-embryonic development GO:0009791 IEA
    response to ionizing radiation GO:0010212 IDA
    regulation of autophagy GO:0010506 IMP
    positive regulation of gene expression GO:0010628 IMP
    peptidyl-serine phosphorylation GO:0018105 IDA
    positive regulation of cell migration GO:0030335 IMP
    negative regulation of B cell proliferation GO:0030889 IMP
    regulation of telomere maintenance via telomerase GO:0032210 IGI
    positive regulation of telomere maintenance via telomerase GO:0032212 ISS
    V(D)J recombination GO:0033151 IEA
    cellular response to stress GO:0033554 IDA
    cellular response to reactive oxygen species GO:0034614 IDA
    multicellular organism growth GO:0035264 IEA
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA
    peptidyl-serine autophosphorylation GO:0036289 IMP
    lipoprotein catabolic process GO:0042159 IEA
    signal transduction in response to DNA damage GO:0042770 IDA
    signal transduction in response to DNA damage GO:0042770 IMP
    regulation of apoptotic process GO:0042981 TAS
    positive regulation of apoptotic process GO:0043065 IMP
    positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 IMP
    positive regulation of neuron apoptotic process GO:0043525 IEA
    meiotic telomere clustering GO:0045141 IEA
    positive regulation of cell adhesion GO:0045785 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    protein autophosphorylation GO:0046777 IDA
    protein autophosphorylation GO:0046777 IMP
    thymus development GO:0048538 IEA
    oocyte development GO:0048599 IEA
    neuron apoptotic process GO:0051402 IEA
    regulation of cell cycle GO:0051726 IMP
    histone mRNA catabolic process GO:0071044 IDA
    cellular response to retinoic acid GO:0071300 ISS
    cellular response to gamma radiation GO:0071480 IDA
    cellular response to X-ray GO:0071481 IDA
    cellular response to nitrosative stress GO:0071500 IDA
    cellular senescence GO:0090398 TAS
    replicative senescence GO:0090399 IMP
    establishment of RNA localization to telomere GO:0097694 IMP
    establishment of protein-containing complex localization to telomere GO:0097695 IMP
    regulation of cellular response to heat GO:1900034 TAS
    regulation of signal transduction by p53 class mediator GO:1901796 TAS
    positive regulation of DNA catabolic process GO:1903626 IEA
    regulation of microglial cell activation GO:1903978 IEA
    negative regulation of TORC1 signaling GO:1904262 IBA
    negative regulation of TORC1 signaling GO:1904262 IMP
    negative regulation of telomere capping GO:1904354 IMP
    positive regulation of telomere maintenance via telomere lengthening GO:1904358 IMP
    positive regulation of telomerase catalytic core complex assembly GO:1904884 IMP
    regulation of autophagosome assembly GO:2000785 IC
Subcellular Localization
    chromosome, telomeric region GO:0000781 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IBA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    peroxisomal matrix GO:0005782 IDA
    peroxisomal matrix GO:0005782 TAS
    centrosome GO:0005813 ISS
    spindle GO:0005819 IEA
    cytosol GO:0005829 TAS
    site of double-strand break GO:0035861 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    extrinsic component of synaptic vesicle membrane GO:0098850 IEA
    DNA repair complex GO:1990391 IDA
 Experiment description of studies that identified ATM in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ATM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
2 LIG4 3981
Protein-peptide Homo sapiens
3 SMC3 9126
Affinity Capture-Western Homo sapiens
4 C5AR2  
Affinity Capture-MS Homo sapiens
5 C5AR1  
Affinity Capture-MS Homo sapiens
6 GMNN  
Affinity Capture-MS Homo sapiens
7 KPNA3 3839
Two-hybrid Homo sapiens
8 NOLC1 9221
Affinity Capture-MS Homo sapiens
9 C1orf27 54953
Affinity Capture-MS Homo sapiens
10 MSH6 2956
Co-purification Homo sapiens
11 HCST  
Affinity Capture-MS Homo sapiens
12 EXO1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 LPAR6  
Affinity Capture-MS Homo sapiens
14 CSNK1A1 1452
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
15 VPRBP 9730
Biochemical Activity Homo sapiens
16 E2F1 1869
Biochemical Activity Homo sapiens
17 ALB 213
Affinity Capture-MS Homo sapiens
18 BRCA1 672
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
19 XPA  
Biochemical Activity Homo sapiens
20 FPR1  
Affinity Capture-MS Homo sapiens
21 SOCS1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
22 ATM 472
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Co-purification Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Co-purification Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
23 CHEK2  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
24 EDNRB 1910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TAF1  
Affinity Capture-MS Homo sapiens
26 SNX6 58533
Affinity Capture-MS Homo sapiens
27 PRKDC 5591
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 RRM2B 50484
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 AMIGO1  
Affinity Capture-MS Homo sapiens
30 PPP1CC 5501
Affinity Capture-Western Homo sapiens
31 RPS6KA3 6197
Biochemical Activity Homo sapiens
32 TOP2A 7153
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Biochemical Activity Homo sapiens
33 RHEB 6009
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
34 TRIM28 10155
Affinity Capture-Western Homo sapiens
35 B3GNT2 10678
Affinity Capture-MS Homo sapiens
36 PELI1 57162
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
37 PPP2R4 5524
Affinity Capture-Western Homo sapiens
38 TAOK3 51347
Affinity Capture-Western Homo sapiens
39 MCM2 4171
Biochemical Activity Homo sapiens
40 DYRK2 8445
Biochemical Activity Homo sapiens
41 Zbtb48  
Affinity Capture-MS Mus musculus
42 BRAT1 221927
Affinity Capture-Western Homo sapiens
43 KDM2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 TELO2 9894
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
45 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 NPM1 4869
Biochemical Activity Homo sapiens
47 MDC1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
48 MAPK14 1432
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
49 UCHL3 7347
Biochemical Activity Homo sapiens
50 HIST1H3A 8350
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
51 EIF3E 3646
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 P2RY10  
Affinity Capture-MS Homo sapiens
53 XPC  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
54 ITFG3 83986
Affinity Capture-MS Homo sapiens
55 HYPM  
Affinity Capture-MS Homo sapiens
56 DNAJC7 7266
Proximity Label-MS Homo sapiens
57 NOD2 64127
Negative Genetic Homo sapiens
58 E4F1  
Protein-peptide Homo sapiens
59 MECP2 4204
Affinity Capture-MS Homo sapiens
60 Mcm3 17215
Biochemical Activity Mus musculus
61 ESRRG  
Two-hybrid Homo sapiens
62 CSNK1D 1453
Biochemical Activity Homo sapiens
63 SMARCB1 6598
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 KPNA1 3836
Two-hybrid Homo sapiens
65 PTH1R  
Affinity Capture-MS Homo sapiens
66 MAS1  
Affinity Capture-MS Homo sapiens
67 TP53BP1 7158
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
68 BAG6 7917
Affinity Capture-MS Homo sapiens
69 FEN1 2237
Synthetic Lethality Homo sapiens
70 WRN 7486
Protein-peptide Homo sapiens
71 MED1 5469
Affinity Capture-Western Homo sapiens
72 MAPK1 5594
Biochemical Activity Homo sapiens
73 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SMO 6608
Negative Genetic Homo sapiens
75 BANP  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
76 PPP1CA 5499
Affinity Capture-Western Homo sapiens
77 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 BHLHE41  
Affinity Capture-MS Homo sapiens
79 GCGR  
Affinity Capture-MS Homo sapiens
80 NHEJ1  
Biochemical Activity Homo sapiens
81 MRE11A 4361
Co-purification Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
82 CTDP1 9150
Affinity Capture-MS Homo sapiens
83 CXXC5  
Reconstituted Complex Homo sapiens
84 CHUK 1147
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
85 CUL3 8452
Affinity Capture-MS Homo sapiens
86 P2RY8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 NDUFA8 4702
Affinity Capture-MS Homo sapiens
88 BLM 641
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
89 NBN 4683
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
90 SIM2  
Affinity Capture-Western Homo sapiens
91 RAD51  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
92 ATF2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
93 TRIM37  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 PAN2  
Biochemical Activity Homo sapiens
95 BRCA2 675
Reconstituted Complex Homo sapiens
96 RPA2 6118
Biochemical Activity Homo sapiens
97 CBL 867
Affinity Capture-Western Homo sapiens
98 GPR182  
Affinity Capture-MS Homo sapiens
99 CHEK1  
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
Negative Genetic Homo sapiens
100 AP1B1 162
Protein-peptide Homo sapiens
101 KPNB1 3837
Affinity Capture-Western Homo sapiens
102 SMC1A 8243
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
103 DDX1 1653
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
104 AP3B1 8546
Protein-peptide Homo sapiens
105 EIF4EBP1  
Protein-peptide Homo sapiens
106 MAPK8 5599
Biochemical Activity Homo sapiens
107 AVPR2  
Affinity Capture-MS Homo sapiens
108 USP28 57646
Affinity Capture-Western Homo sapiens
109 GLTSCR2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 IGHM 3507
Affinity Capture-MS Homo sapiens
111 MLNR  
Affinity Capture-MS Homo sapiens
112 RAP2A 5911
Affinity Capture-MS Homo sapiens
113 UTP15 84135
Affinity Capture-MS Homo sapiens
114 PARP3 10039
Co-localization Homo sapiens
115 TTI1 9675
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
116 MINK1 50488
Affinity Capture-MS Homo sapiens
117 RNF40 9810
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
118 SPSB1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
119 CYB5B 80777
Affinity Capture-MS Homo sapiens
120 EFNA4  
Affinity Capture-MS Homo sapiens
121 APLNR  
Affinity Capture-MS Homo sapiens
122 RAD17  
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 CXCR4 7852
Affinity Capture-MS Homo sapiens
124 FANCD2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
125 TCL1A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
126 PRKCA 5578
Synthetic Lethality Homo sapiens
127 MSH2 4436
Co-purification Homo sapiens
128 ARRDC4  
Affinity Capture-MS Homo sapiens
129 RBM47 54502
Affinity Capture-MS Homo sapiens
130 RELA 5970
Co-localization Homo sapiens
131 SIRT7  
Affinity Capture-MS Homo sapiens
132 LRRC25  
Affinity Capture-MS Homo sapiens
133 NPTN 27020
Affinity Capture-MS Homo sapiens
134 PTH2R  
Affinity Capture-MS Homo sapiens
135 SREBF1 6720
Affinity Capture-Western Homo sapiens
136 PRMT8  
Affinity Capture-MS Homo sapiens
137 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 TRAF6 7189
Reconstituted Complex Homo sapiens
139 SKP2  
Affinity Capture-Western Homo sapiens
140 TDP1  
Affinity Capture-Western Homo sapiens
141 RASSF1  
Protein-peptide Homo sapiens
142 NPY2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 KDM6A  
Negative Genetic Homo sapiens
144 DCLRE1C  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
145 EP400  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
146 HNRNPUL1 11100
Affinity Capture-Western Homo sapiens
147 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
148 POLR2A 5430
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
149 VHL  
Affinity Capture-Western Homo sapiens
Negative Genetic Homo sapiens
150 ATMIN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
151 OCIAD1 54940
Affinity Capture-MS Homo sapiens
152 RFC1 5981
Co-purification Homo sapiens
153 MAGEC2  
Affinity Capture-Western Homo sapiens
154 ATRIP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
155 RANBP9 10048
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
156 SRSF8 10929
Affinity Capture-MS Homo sapiens
157 GNA11 2767
Affinity Capture-MS Homo sapiens
158 STAT1 6772
Affinity Capture-Western Homo sapiens
159 NRD1 4898
Affinity Capture-MS Homo sapiens
160 FUS 2521
Biochemical Activity Homo sapiens
161 GPR45  
Affinity Capture-MS Homo sapiens
162 WWC1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
163 P3H2  
Affinity Capture-MS Homo sapiens
164 TOP1 7150
Protein-peptide Homo sapiens
165 KAT5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
166 SCN2B  
Affinity Capture-MS Homo sapiens
167 SNW1 22938
Affinity Capture-MS Homo sapiens
168 PARP1 142
Cross-Linking-MS (XL-MS) Homo sapiens
Reconstituted Complex Homo sapiens
169 BMI1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
170 Nedd1  
Affinity Capture-MS Mus musculus
171 SLC22A4 6583
Affinity Capture-MS Homo sapiens
172 PML 5371
Affinity Capture-MS Homo sapiens
173 APLF  
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
174 IL6R  
Negative Genetic Homo sapiens
175 ZER1 10444
Affinity Capture-MS Homo sapiens
176 MDM2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
177 CDKN2C  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
178 XRCC5 7520
Reconstituted Complex Homo sapiens
179 HUWE1 10075
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
180 Ap3b2  
Affinity Capture-Western Mus musculus
181 RBBP8  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
182 H2AFX 3014
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
183 HIF1A 3091
Biochemical Activity Homo sapiens
184 CD99L2 83692
Affinity Capture-MS Homo sapiens
185 GPR17 2840
Affinity Capture-MS Homo sapiens
186 Ap1b1 11764
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
187 FOXO3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
188 SPOP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
189 TERF2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
190 KAT8  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
191 GAPDHS 26330
Affinity Capture-MS Homo sapiens
192 SNAI1  
Affinity Capture-MS Homo sapiens
193 SMAD7  
Affinity Capture-Western Homo sapiens
194 TOPBP1 11073
Affinity Capture-Western Homo sapiens
195 TP53 7157
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Enhancement Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
196 USP34 9736
Affinity Capture-Western Homo sapiens
197 OPALIN  
Affinity Capture-MS Homo sapiens
198 MTMR3  
Affinity Capture-MS Homo sapiens
199 WWOX 51741
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
200 ZEB1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
201 MTRR  
Affinity Capture-MS Homo sapiens
202 DCAF13 25879
Affinity Capture-MS Homo sapiens
203 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
204 EDEM1  
Affinity Capture-MS Homo sapiens
205 KPNA5 3841
Two-hybrid Homo sapiens
206 Bid  
Biochemical Activity Mus musculus
207 ABL1 25
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
208 CDC6  
Reconstituted Complex Homo sapiens
209 FANCI 55215
Affinity Capture-Western Homo sapiens
210 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
211 MLH1 4292
Co-purification Homo sapiens
212 HDAC1 3065
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
213 CHD4 1108
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
214 RNF20 56254
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
215 BCL10  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
216 CREB1  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
217 DDX58 23586
Affinity Capture-RNA Homo sapiens
218 HTR6  
Affinity Capture-MS Homo sapiens
219 RAD50 10111
Co-purification Homo sapiens
220 CD80 941
Affinity Capture-MS Homo sapiens
221 EPHA5 2044
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
222 MCPH1  
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
223 TERF1 7013
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
224 IK 3550
Affinity Capture-RNA Homo sapiens
225 ERRFI1 54206
Affinity Capture-Western Homo sapiens
226 DCLRE1A  
Affinity Capture-Western Homo sapiens
227 CDK9 1025
Co-localization Homo sapiens
228 DAXX  
Biochemical Activity Homo sapiens
229 STK11 6794
Affinity Capture-Western Homo sapiens
230 PER3  
Affinity Capture-Western Homo sapiens
231 SETD2  
Negative Genetic Homo sapiens
232 PEX5 5830
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
233 LPAR4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
234 DRD4  
Affinity Capture-MS Homo sapiens
235 UCK1  
Affinity Capture-MS Homo sapiens
236 IKBKB 3551
Affinity Capture-Western Homo sapiens
237 RPS6KA1 6195
Biochemical Activity Homo sapiens
238 Atm  
Affinity Capture-MS Mus musculus
239 ADGRG2 10149
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATM is involved
PathwayEvidenceSource
Autodegradation of the E3 ubiquitin ligase COP1 TAS Reactome
Autophagy TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function TAS Reactome
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function TAS Reactome
Defective homologous recombination repair (HRR) due to BRCA1 loss of function TAS Reactome
Defective homologous recombination repair (HRR) due to BRCA2 loss of function TAS Reactome
Defective homologous recombination repair (HRR) due to PALB2 loss of function TAS Reactome
Disease TAS Reactome
Diseases of DNA Double-Strand Break Repair TAS Reactome
Diseases of DNA repair TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
G1/S DNA Damage Checkpoints TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
HDR through Homologous Recombination (HRR) TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
HDR through Single Strand Annealing (SSA) TAS Reactome
Homologous DNA Pairing and Strand Exchange TAS Reactome
Homology Directed Repair TAS Reactome
Impaired BRCA2 binding to PALB2 TAS Reactome
Impaired BRCA2 binding to RAD51 TAS Reactome
Macroautophagy TAS Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
p53-Dependent G1 DNA Damage Response TAS Reactome
p53-Dependent G1/S DNA damage checkpoint TAS Reactome
Pexophagy TAS Reactome
Presynaptic phase of homologous DNA pairing and strand exchange TAS Reactome
Processing of DNA double-strand break ends TAS Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of HSF1-mediated heat shock response TAS Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Activity through Methylation TAS Reactome
Regulation of TP53 Activity through Phosphorylation TAS Reactome
Regulation of TP53 Degradation TAS Reactome
Regulation of TP53 Expression and Degradation TAS Reactome
Reproduction IEA Reactome
Resolution of D-Loop Structures TAS Reactome
Resolution of D-loop Structures through Holliday Junction Intermediates TAS Reactome
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) TAS Reactome
RNA Polymerase II Transcription TAS Reactome
Selective autophagy TAS Reactome
Sensing of DNA Double Strand Breaks TAS Reactome
Stabilization of p53 TAS Reactome
TP53 Regulates Transcription of Caspase Activators and Caspases TAS Reactome
TP53 Regulates Transcription of Cell Death Genes TAS Reactome
TP53 Regulates Transcription of DNA Repair Genes TAS Reactome
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome





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