Gene description for A2ML1
Gene name alpha-2-macroglobulin-like 1
Gene symbol A2ML1
Other names/aliases CPAMD9
Species Homo sapiens
 Database cross references - A2ML1
ExoCarta ExoCarta_144568
Entrez Gene 144568
HGNC 23336
MIM 610627
UniProt A8K2U0  
 A2ML1 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for A2ML1
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    peptidase inhibitor activity GO:0030414 IDA
Biological Process
    regulation of endopeptidase activity GO:0052548 IDA
    negative regulation of endopeptidase activity GO:0010951 IEA
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified A2ML1 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for A2ML1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which A2ML1 is involved
No pathways found





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