Gene description for BDH2
Gene name 3-hydroxybutyrate dehydrogenase, type 2
Gene symbol BDH2
Other names/aliases DHRS6
EFA6R
PRO20933
SDR15C1
UCPA-OR
UNQ6308
Species Homo sapiens
 Database cross references - BDH2
ExoCarta ExoCarta_56898
Entrez Gene 56898
HGNC 32389
UniProt Q9BUT1  
 BDH2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for BDH2
Molecular Function
    3-hydroxybutyrate dehydrogenase activity GO:0003858 IDA
    oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628 ISS
    NAD binding GO:0051287 IDA
Biological Process
    fatty acid beta-oxidation GO:0006635 IDA
    iron ion homeostasis GO:0055072 ISS
    heme metabolic process GO:0042168 ISS
    epithelial cell differentiation GO:0030855 IDA
    siderophore biosynthetic process GO:0019290 ISS
Subcellular Localization
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified BDH2 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BDH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which BDH2 is involved
No pathways found





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