Gene description for MYH7
Gene name myosin, heavy chain 7, cardiac muscle, beta
Gene symbol MYH7
Other names/aliases CMD1S
CMH1
MPD1
MYHCB
SPMD
SPMM
Species Homo sapiens
 Database cross references - MYH7
ExoCarta ExoCarta_4625
Vesiclepedia VP_4625
Entrez Gene 4625
HGNC 7577
MIM 160760
UniProt P12883  
 MYH7 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for MYH7
Molecular Function
    microfilament motor activity GO:0000146 IBA
    microfilament motor activity GO:0000146 IDA
    microfilament motor activity GO:0000146 IMP
    microfilament motor activity GO:0000146 NAS
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
    ATP binding GO:0005524 IEA
    actin filament binding GO:0051015 IBA
Biological Process
    regulation of the force of heart contraction GO:0002026 IDA
    regulation of heart rate GO:0002027 IDA
    skeletal muscle contraction GO:0003009 IMP
    muscle contraction GO:0006936 IDA
    muscle contraction GO:0006936 TAS
    striated muscle contraction GO:0006941 IDA
    adult heart development GO:0007512 IBA
    adult heart development GO:0007512 IMP
    regulation of the force of skeletal muscle contraction GO:0014728 IMP
    transition between fast and slow fiber GO:0014883 IEA
    cardiac muscle hypertrophy in response to stress GO:0014898 IEA
    muscle filament sliding GO:0030049 IBA
    muscle filament sliding GO:0030049 IMP
    regulation of slow-twitch skeletal muscle fiber contraction GO:0031449 IMP
    ATP metabolic process GO:0046034 IDA
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP
    cardiac muscle contraction GO:0060048 IBA
    cardiac muscle contraction GO:0060048 IMP
Subcellular Localization
    stress fiber GO:0001725 IEA
    cytoplasm GO:0005737 IBA
    muscle myosin complex GO:0005859 TAS
    myosin complex GO:0016459 TAS
    myosin II complex GO:0016460 IBA
    myofibril GO:0030016 ISS
    sarcomere GO:0030017 ISS
    sarcomere GO:0030017 TAS
    Z disc GO:0030018 IEA
    myosin filament GO:0032982 IBA
    myosin filament GO:0032982 IDA
 Experiment description of studies that identified MYH7 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MYH7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL9 55958
Affinity Capture-MS Homo sapiens
2 PDCD6 10016
Affinity Capture-MS Homo sapiens
3 TARSL2 123283
Affinity Capture-MS Homo sapiens
4 CDCA8 55143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ROGDI 79641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 DISC1 27185
Two-hybrid Homo sapiens
7 SPTAN1 6709
Affinity Capture-MS Homo sapiens
8 ACTN2 88
Co-fractionation Homo sapiens
9 PPP3R1 5534
Affinity Capture-MS Homo sapiens
10 AFF1  
Affinity Capture-MS Homo sapiens
11 MECOM 2122
Affinity Capture-MS Homo sapiens
12 SIRT6  
Affinity Capture-MS Homo sapiens
13 CLINT1 9685
Affinity Capture-MS Homo sapiens
14 DVL2 1856
Affinity Capture-MS Homo sapiens
15 RBPJ 3516
Affinity Capture-MS Homo sapiens
16 SLC39A3  
Affinity Capture-MS Homo sapiens
17 ECD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 GJA1 2697
Affinity Capture-MS Homo sapiens
19 WWOX 51741
Affinity Capture-MS Homo sapiens
20 POLR2L 5441
Affinity Capture-MS Homo sapiens
21 TPM2 7169
Co-fractionation Homo sapiens
22 LACTB2 51110
Affinity Capture-MS Homo sapiens
23 TGS1  
Affinity Capture-MS Homo sapiens
24 TSPAN33 340348
Affinity Capture-MS Homo sapiens
25 KEAP1 9817
Affinity Capture-MS Homo sapiens
26 LIMS1 3987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 EFNA1  
Affinity Capture-MS Homo sapiens
28 PRDX5 25824
Affinity Capture-MS Homo sapiens
29 TLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
31 PSMD4 5710
Affinity Capture-MS Homo sapiens
32 FKBP6  
Affinity Capture-MS Homo sapiens
33 HDAC1 3065
Affinity Capture-MS Homo sapiens
34 AAR2 25980
Affinity Capture-MS Homo sapiens
35 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
36 SIX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 FAM124B  
Affinity Capture-MS Homo sapiens
38 LATS1  
Affinity Capture-MS Homo sapiens
39 CLSPN  
Affinity Capture-MS Homo sapiens
40 SHD  
Affinity Capture-MS Homo sapiens
41 NTHL1  
Affinity Capture-MS Homo sapiens
42 RSPH6A  
Affinity Capture-MS Homo sapiens
43 APOC1  
Cross-Linking-MS (XL-MS) Homo sapiens
44 ZSCAN5A  
Affinity Capture-MS Homo sapiens
45 SEC61B 10952
Affinity Capture-MS Homo sapiens
46 TAF11  
Affinity Capture-MS Homo sapiens
47 ASAH2 56624
Affinity Capture-MS Homo sapiens
48 TMEM260  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SYT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 AKAP17A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CCDC69 26112
Affinity Capture-MS Homo sapiens
52 BTF3 689
Affinity Capture-MS Homo sapiens
53 ACTN3 89
Co-fractionation Homo sapiens
54 KRT40  
Affinity Capture-MS Homo sapiens
55 CHRM5  
Two-hybrid Homo sapiens
56 POLD1 5424
Affinity Capture-MS Homo sapiens
57 KXD1 79036
Two-hybrid Homo sapiens
58 ERP29 10961
Cross-Linking-MS (XL-MS) Homo sapiens
59 FAM58A  
Affinity Capture-MS Homo sapiens
60 MYH4  
Affinity Capture-MS Homo sapiens
61 YWHAQ 10971
Affinity Capture-MS Homo sapiens
62 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
63 NPM1 4869
Cross-Linking-MS (XL-MS) Homo sapiens
64 LHPP 64077
Affinity Capture-MS Homo sapiens
65 KIAA0368 23392
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
66 LZTR1 8216
Affinity Capture-MS Homo sapiens
67 PRKAR1B  
Affinity Capture-MS Homo sapiens
68 RBSN 64145
Affinity Capture-MS Homo sapiens
69 TAF6L 10629
Affinity Capture-MS Homo sapiens
70 TNNI1 7135
Co-fractionation Homo sapiens
71 APOA1 335
Cross-Linking-MS (XL-MS) Homo sapiens
72 APOL1 8542
Cross-Linking-MS (XL-MS) Homo sapiens
73 C1orf189  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MYH7 is involved
No pathways found





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