Gene description for ERGIC1
Gene name endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
Gene symbol ERGIC1
Other names/aliases ERGIC-32
ERGIC32
NET24
Species Homo sapiens
 Database cross references - ERGIC1
ExoCarta ExoCarta_57222
Vesiclepedia VP_57222
Entrez Gene 57222
HGNC 29205
UniProt Q969X5  
 ERGIC1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ERGIC1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IDA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IBA
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    membrane GO:0016020 HDA
    COPII-coated ER to Golgi transport vesicle GO:0030134 IBA
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified ERGIC1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
15
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
16
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
17
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
21
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ERGIC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 ITGB1 3688
Proximity Label-MS Homo sapiens
4 Myh3  
Affinity Capture-MS Mus musculus
5 WDR6 11180
Proximity Label-MS Homo sapiens
6 ANKLE2 23141
Proximity Label-MS Homo sapiens
7 SLC1A5 6510
Proximity Label-MS Homo sapiens
8 AGPAT1 10554
Proximity Label-MS Homo sapiens
9 OCLN 100506658
Proximity Label-MS Homo sapiens
10 SNAP23 8773
Proximity Label-MS Homo sapiens
11 PRKCD 5580
Proximity Label-MS Homo sapiens
12 VAPA 9218
Proximity Label-MS Homo sapiens
13 DHRS7 51635
Proximity Label-MS Homo sapiens
14 LLGL1 3996
Proximity Label-MS Homo sapiens
15 SRPRB 58477
Proximity Label-MS Homo sapiens
16 ARL6IP5 10550
Proximity Label-MS Homo sapiens
17 RPA2 6118
Affinity Capture-MS Homo sapiens
18 JPH1 56704
Proximity Label-MS Homo sapiens
19 SLC30A1 7779
Proximity Label-MS Homo sapiens
20 ARFGAP3 26286
Proximity Label-MS Homo sapiens
21 SLC29A1 2030
Proximity Label-MS Homo sapiens
22 SLC2A1 6513
Proximity Label-MS Homo sapiens
23 Trp53bp1  
Affinity Capture-MS Mus musculus
24 ARCN1 372
Proximity Label-MS Homo sapiens
25 SYNE2 23224
Proximity Label-MS Homo sapiens
26 GOSR2 9570
Proximity Label-MS Homo sapiens
27 PTPN1 5770
Proximity Label-MS Homo sapiens
28 SNX6 58533
Proximity Label-MS Homo sapiens
29 COPA 1314
Affinity Capture-MS Homo sapiens
30 ARHGAP1 392
Proximity Label-MS Homo sapiens
31 FFAR1  
Affinity Capture-MS Homo sapiens
32 PTPN2 5771
Proximity Label-MS Homo sapiens
33 KLK2  
Affinity Capture-MS Homo sapiens
34 MFAP5  
Affinity Capture-MS Homo sapiens
35 PDE2A  
Affinity Capture-MS Homo sapiens
36 TRPM7 54822
Proximity Label-MS Homo sapiens
37 KIAA1429 25962
Affinity Capture-MS Homo sapiens
38 TEX264 51368
Proximity Label-MS Homo sapiens
39 INA 9118
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 WDR41  
Proximity Label-MS Homo sapiens
41 DGKH 160851
Proximity Label-MS Homo sapiens
42 HELZ 9931
Proximity Label-MS Homo sapiens
43 RAB40C 57799
Affinity Capture-MS Homo sapiens
44 COPB2 9276
Affinity Capture-MS Homo sapiens
45 TMED2 10959
Co-fractionation Homo sapiens
46 CISD2 493856
Proximity Label-MS Homo sapiens
47 TOMM7 54543
Co-fractionation Homo sapiens
48 RER1 11079
Proximity Label-MS Homo sapiens
49 PGRMC2 10424
Proximity Label-MS Homo sapiens
50 RAB1A 5861
Proximity Label-MS Homo sapiens
51 TMEM38B  
Proximity Label-MS Homo sapiens
52 CCDC47 57003
Proximity Label-MS Homo sapiens
53 NDUFV1 4723
Co-fractionation Homo sapiens
54 TOMM40 10452
Co-fractionation Homo sapiens
55 ALCAM 214
Proximity Label-MS Homo sapiens
56 SLC19A1 6573
Proximity Label-MS Homo sapiens
57 SCD5  
Proximity Label-MS Homo sapiens
58 SLC30A9 10463
Proximity Label-MS Homo sapiens
59 FZD7 8324
Affinity Capture-MS Homo sapiens
60 Kif2c 73804
Affinity Capture-MS Mus musculus
61 FAF2 23197
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
62 TMEM2 23670
Proximity Label-MS Homo sapiens
63 RDH10 157506
Affinity Capture-MS Homo sapiens
64 TFRC 7037
Proximity Label-MS Homo sapiens
65 KIF14 9928
Affinity Capture-MS Homo sapiens
66 NOTCH2 4853
Proximity Label-MS Homo sapiens
67 TMEM209 84928
Proximity Label-MS Homo sapiens
68 RAB1B 81876
Affinity Capture-MS Homo sapiens
69 LMAN1 3998
Proximity Label-MS Homo sapiens
70 PDZD8 118987
Proximity Label-MS Homo sapiens
71 E2F4  
Affinity Capture-MS Homo sapiens
72 LRRC59 55379
Proximity Label-MS Homo sapiens
73 LEMD3  
Proximity Label-MS Homo sapiens
74 VKORC1L1 154807
Proximity Label-MS Homo sapiens
75 MRPL32 64983
Co-fractionation Homo sapiens
76 CHMP7 91782
Proximity Label-MS Homo sapiens
77 HS2ST1 9653
Affinity Capture-MS Homo sapiens
78 CANT1 124583
Proximity Label-MS Homo sapiens
79 SMPD4 55627
Proximity Label-MS Homo sapiens
80 RABL3 285282
Proximity Label-MS Homo sapiens
81 EMD 2010
Proximity Label-MS Homo sapiens
82 SAR1A 56681
Proximity Label-MS Homo sapiens
83 COPE 11316
Affinity Capture-MS Homo sapiens
84 HSP90B1 7184
Proximity Label-MS Homo sapiens
85 LYN 4067
Proximity Label-MS Homo sapiens
86 MCAM 4162
Proximity Label-MS Homo sapiens
87 SNAP47 116841
Proximity Label-MS Homo sapiens
88 VAMP3 9341
Proximity Label-MS Homo sapiens
89 CERS2 29956
Proximity Label-MS Homo sapiens
90 STT3B 201595
Proximity Label-MS Homo sapiens
91 CDKAL1  
Proximity Label-MS Homo sapiens
92 VAMP2 6844
Proximity Label-MS Homo sapiens
93 APOL2 23780
Proximity Label-MS Homo sapiens
94 YIF1A 10897
Proximity Label-MS Homo sapiens
95 VAPB 9217
Proximity Label-MS Homo sapiens
96 NTRK1 4914
Affinity Capture-MS Homo sapiens
97 GORASP2 26003
Proximity Label-MS Homo sapiens
98 SRPR 6734
Proximity Label-MS Homo sapiens
99 MIA3 375056
Proximity Label-MS Homo sapiens
100 P4HB 5034
Proximity Label-MS Homo sapiens
101 RPN1 6184
Proximity Label-MS Homo sapiens
102 ATP6V1B1 525
Co-fractionation Homo sapiens
103 GNAI2 2771
Co-fractionation Homo sapiens
104 STX5 6811
Proximity Label-MS Homo sapiens
105 CTR9 9646
Affinity Capture-MS Homo sapiens
106 MRPL11 65003
Co-fractionation Homo sapiens
107 CDC42EP1 11135
Proximity Label-MS Homo sapiens
108 ATP5B 506
Proximity Label-MS Homo sapiens
109 VMP1 81671
Proximity Label-MS Homo sapiens
110 ACBD3 64746
Proximity Label-MS Homo sapiens
111 SLC4A7 9497
Proximity Label-MS Homo sapiens
112 REEP5 7905
Proximity Label-MS Homo sapiens
113 DUSP22  
Affinity Capture-MS Homo sapiens
114 LYPD6B 130576
Affinity Capture-MS Homo sapiens
115 RAB6A 5870
Proximity Label-MS Homo sapiens
116 ANO6 196527
Proximity Label-MS Homo sapiens
117 CYB5B 80777
Proximity Label-MS Homo sapiens
118 FAM83B  
Proximity Label-MS Homo sapiens
119 ITPR2 3709
Proximity Label-MS Homo sapiens
120 ADCY9 115
Proximity Label-MS Homo sapiens
121 RPN2 6185
Proximity Label-MS Homo sapiens
122 CANX 821
Proximity Label-MS Homo sapiens
123 SLC38A1 81539
Proximity Label-MS Homo sapiens
124 TMPO 7112
Proximity Label-MS Homo sapiens
125 DHCR7 1717
Proximity Label-MS Homo sapiens
126 LMNB1 4001
Proximity Label-MS Homo sapiens
127 HIGD1A 25994
Co-fractionation Homo sapiens
128 KRT86  
Affinity Capture-MS Homo sapiens
129 ATP2B1 490
Proximity Label-MS Homo sapiens
130 SCAMP1 9522
Proximity Label-MS Homo sapiens
131 CHST8 64377
Affinity Capture-MS Homo sapiens
132 HMOX2 3163
Proximity Label-MS Homo sapiens
133 PPIB 5479
Proximity Label-MS Homo sapiens
134 B3GNT3 10331
Affinity Capture-MS Homo sapiens
135 SLC30A6 55676
Proximity Label-MS Homo sapiens
136 ERGIC3 51614
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
137 BCAP31 10134
Proximity Label-MS Homo sapiens
138 TMEM199  
Proximity Label-MS Homo sapiens
139 ATP6AP2 10159
Proximity Label-MS Homo sapiens
140 FYN 2534
Proximity Label-MS Homo sapiens
141 STIM1 6786
Proximity Label-MS Homo sapiens
142 DDRGK1 65992
Proximity Label-MS Homo sapiens
143 FKBP8 23770
Proximity Label-MS Homo sapiens
144 IGF2R 3482
Proximity Label-MS Homo sapiens
145 SLC7A5 8140
Proximity Label-MS Homo sapiens
146 SUN1 23353
Proximity Label-MS Homo sapiens
147 SUZ12  
Affinity Capture-MS Homo sapiens
148 TFG 10342
Affinity Capture-MS Homo sapiens
149 OCIAD1 54940
Proximity Label-MS Homo sapiens
150 SNX19  
Proximity Label-MS Homo sapiens
151 BIRC6 57448
Proximity Label-MS Homo sapiens
152 SOAT1 6646
Proximity Label-MS Homo sapiens
153 IST1 9798
Co-fractionation Homo sapiens
154 ACSL3 2181
Proximity Label-MS Homo sapiens
155 RFT1 91869
Proximity Label-MS Homo sapiens
156 RPA3 6119
Affinity Capture-MS Homo sapiens
157 SLC3A2 6520
Proximity Label-MS Homo sapiens
158 SEC16A 9919
Proximity Label-MS Homo sapiens
159 FAM134B 54463
Proximity Label-MS Homo sapiens
160 ABCC1 4363
Proximity Label-MS Homo sapiens
161 UBIAD1 29914
Proximity Label-MS Homo sapiens
162 Cep78  
Affinity Capture-MS Mus musculus
163 SLC6A15 55117
Proximity Label-MS Homo sapiens
164 VRK2 7444
Proximity Label-MS Homo sapiens
165 FNDC3A 22862
Proximity Label-MS Homo sapiens
166 HYOU1 10525
Proximity Label-MS Homo sapiens
167 STBD1 8987
Proximity Label-MS Homo sapiens
168 CLCC1 23155
Proximity Label-MS Homo sapiens
169 DOLPP1  
Proximity Label-MS Homo sapiens
170 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
171 HLA-A 3105
Proximity Label-MS Homo sapiens
172 HSD17B12 51144
Proximity Label-MS Homo sapiens
173 SLC12A2 6558
Proximity Label-MS Homo sapiens
174 UBE2J1 51465
Proximity Label-MS Homo sapiens
175 GOLGB1 2804
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
176 Smchd1  
Affinity Capture-MS Mus musculus
177 RAB33A 9363
Affinity Capture-MS Homo sapiens
178 FLVCR1 28982
Proximity Label-MS Homo sapiens
179 MBOAT7 79143
Proximity Label-MS Homo sapiens
180 DEPDC1B 55789
Proximity Label-MS Homo sapiens
181 SLC38A2 54407
Proximity Label-MS Homo sapiens
182 SLC39A6 25800
Proximity Label-MS Homo sapiens
183 ALDH3A2 224
Proximity Label-MS Homo sapiens
184 COPZ1 22818
Affinity Capture-MS Homo sapiens
185 TMEM57  
Proximity Label-MS Homo sapiens
186 UBXN4 23190
Proximity Label-MS Homo sapiens
187 PRAF2 11230
Proximity Label-MS Homo sapiens
188 SEC23IP 11196
Proximity Label-MS Homo sapiens
189 TOR1AIP2 163590
Proximity Label-MS Homo sapiens
190 AGPAT9  
Proximity Label-MS Homo sapiens
191 PGRMC1 10857
Proximity Label-MS Homo sapiens
192 SPTBN2 6712
Proximity Label-MS Homo sapiens
193 ICT1 3396
Co-fractionation Homo sapiens
194 PDIA4 9601
Proximity Label-MS Homo sapiens
195 LSR 51599
Proximity Label-MS Homo sapiens
196 DNAJA2 10294
Proximity Label-MS Homo sapiens
197 TACC1 6867
Proximity Label-MS Homo sapiens
198 EHHADH 1962
Two-hybrid Homo sapiens
199 RPA1 6117
Affinity Capture-MS Homo sapiens
200 CAMLG 819
Proximity Label-MS Homo sapiens
201 NDC1 55706
Proximity Label-MS Homo sapiens
202 EFNB1 1947
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 PIGU 128869
Proximity Label-MS Homo sapiens
204 ITPR3 3710
Proximity Label-MS Homo sapiens
205 EBP  
Proximity Label-MS Homo sapiens
206 SLC39A14 23516
Proximity Label-MS Homo sapiens
207 SEC24A 10802
Proximity Label-MS Homo sapiens
208 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
209 TMX1 81542
Proximity Label-MS Homo sapiens
210 TRIP11 9321
Proximity Label-MS Homo sapiens
211 MMGT1 93380
Proximity Label-MS Homo sapiens
212 ITGA2 3673
Co-fractionation Homo sapiens
213 AUP1 550
Proximity Label-MS Homo sapiens
214 FADS2 9415
Proximity Label-MS Homo sapiens
215 HOXB1  
Affinity Capture-MS Homo sapiens
216 ERGIC2 51290
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
217 BSG 682
Proximity Label-MS Homo sapiens
218 HM13 81502
Proximity Label-MS Homo sapiens
219 GOLGA5 9950
Proximity Label-MS Homo sapiens
220 WWOX 51741
Proximity Label-MS Homo sapiens
221 SLC33A1 9197
Proximity Label-MS Homo sapiens
222 RAB7A 7879
Proximity Label-MS Homo sapiens
223 ATP1A1 476
Proximity Label-MS Homo sapiens
224 SLC6A8 6535
Proximity Label-MS Homo sapiens
225 YKT6 10652
Proximity Label-MS Homo sapiens
226 ARF1 375
Proximity Label-MS Homo sapiens
227 AGPAT6 137964
Proximity Label-MS Homo sapiens
228 EPHA2 1969
Proximity Label-MS Homo sapiens
229 CDKN2A 1029
Proximity Label-MS Homo sapiens
230 EI24  
Proximity Label-MS Homo sapiens
231 PRPF4 9128
Affinity Capture-MS Homo sapiens
232 DNAJC1 64215
Proximity Label-MS Homo sapiens
233 C9orf72  
Affinity Capture-MS Homo sapiens
234 SYN1  
Affinity Capture-MS Homo sapiens
235 LRRC49  
Proximity Label-MS Homo sapiens
236 CKAP4 10970
Proximity Label-MS Homo sapiens
237 VANGL1 81839
Proximity Label-MS Homo sapiens
238 UQCRFS1 7386
Co-fractionation Homo sapiens
239 CAV1 857
Proximity Label-MS Homo sapiens
240 ESYT1 23344
Proximity Label-MS Homo sapiens
241 VEZT 55591
Proximity Label-MS Homo sapiens
242 SPCS2 9789
Proximity Label-MS Homo sapiens
243 ATP13A1 57130
Proximity Label-MS Homo sapiens
244 HLA-C 3107
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ERGIC1 is involved
No pathways found





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