Gene description for KIAA1522
Gene name KIAA1522
Gene symbol KIAA1522
Other names/aliases -
Species Homo sapiens
 Database cross references - KIAA1522
ExoCarta ExoCarta_57648
Vesiclepedia VP_57648
Entrez Gene 57648
HGNC 29301
UniProt Q9P206  
 KIAA1522 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for KIAA1522
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell differentiation GO:0030154 IBA
 Experiment description of studies that identified KIAA1522 in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KIAA1522
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 RPSAP58 388524
Affinity Capture-MS Homo sapiens
3 RPL26L1 51121
Affinity Capture-MS Homo sapiens
4 OCLN 100506658
Proximity Label-MS Homo sapiens
5 MARCKS 4082
Proximity Label-MS Homo sapiens
6 KIAA0020 9933
Affinity Capture-MS Homo sapiens
7 WASF2 10163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
9 ANAPC15  
Affinity Capture-MS Homo sapiens
10 NMNAT1  
Affinity Capture-MS Homo sapiens
11 Csk 12988
Affinity Capture-MS Mus musculus
12 EVL 51466
Affinity Capture-MS Homo sapiens
13 VASP 7408
Affinity Capture-MS Homo sapiens
14 ANKRD50 57182
Affinity Capture-MS Homo sapiens
15 MLLT4 4301
Affinity Capture-MS Homo sapiens
16 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CHCHD2  
Affinity Capture-MS Homo sapiens
18 YWHAG 7532
Affinity Capture-MS Homo sapiens
19 ABI1 10006
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SFRP1 6422
Two-hybrid Homo sapiens
21 PLCG1 5335
Affinity Capture-MS Homo sapiens
22 SRP68 6730
Affinity Capture-MS Homo sapiens
23 RAB35 11021
Proximity Label-MS Homo sapiens
24 NCK2 8440
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 NCK1 4690
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
26 MAK16  
Affinity Capture-MS Homo sapiens
27 WASF3 10810
Affinity Capture-MS Homo sapiens
28 RBM8A 9939
Affinity Capture-MS Homo sapiens
29 Tmed10 68581
Affinity Capture-MS Mus musculus
30 PFN1 5216
Affinity Capture-MS Homo sapiens
31 ARHGAP12  
Affinity Capture-MS Homo sapiens
32 WASF1 8936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CTDP1 9150
Affinity Capture-MS Homo sapiens
34 Ddb1 13194
Affinity Capture-MS Mus musculus
35 NHS 4810
Affinity Capture-MS Homo sapiens
36 LYN 4067
Proximity Label-MS Homo sapiens
37 CDH1 999
Proximity Label-MS Homo sapiens
38 C17orf70  
Affinity Capture-MS Homo sapiens
39 ACTB 60
Proximity Label-MS Homo sapiens
40 TACC3  
Affinity Capture-MS Homo sapiens
41 ENAH 55740
Affinity Capture-MS Homo sapiens
42 ACTG1 71
Affinity Capture-MS Homo sapiens
43 ASAP2 8853
Affinity Capture-MS Homo sapiens
44 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
45 PPAN-P2RY11  
Affinity Capture-MS Homo sapiens
46 PKMYT1  
Affinity Capture-MS Homo sapiens
47 Strn3  
Affinity Capture-MS Mus musculus
48 NCKAP1 10787
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 LAMP1 3916
Proximity Label-MS Homo sapiens
50 NPM3 10360
Affinity Capture-MS Homo sapiens
51 NHSL1  
Affinity Capture-MS Homo sapiens
52 THOC5 8563
Affinity Capture-MS Homo sapiens
53 CYFIP2 26999
Affinity Capture-MS Homo sapiens
54 BAIAP2L1 55971
Affinity Capture-MS Homo sapiens
55 Nr4a2  
Affinity Capture-MS Mus musculus
56 KCNE3  
Affinity Capture-MS Homo sapiens
57 EPHA2 1969
Proximity Label-MS Homo sapiens
58 SET 6418
Affinity Capture-MS Homo sapiens
59 DHPS 1725
Affinity Capture-MS Homo sapiens
60 POLR1A  
Affinity Capture-MS Homo sapiens
61 SORBS3 10174
Affinity Capture-MS Homo sapiens
62 RHOB 388
Proximity Label-MS Homo sapiens
63 Rpl35 66489
Affinity Capture-MS Mus musculus
64 ASAP1 50807
Affinity Capture-MS Homo sapiens
65 BMP4 652
Affinity Capture-MS Homo sapiens
66 BAIAP2 10458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
68 FLOT1 10211
Proximity Label-MS Homo sapiens
69 H2AFX 3014
Affinity Capture-MS Homo sapiens
70 NIP7 51388
Affinity Capture-MS Homo sapiens
71 RNF43  
Proximity Label-MS Homo sapiens
72 SLMAP 7871
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 ITIH6  
Affinity Capture-MS Homo sapiens
74 RRS1 23212
Affinity Capture-MS Homo sapiens
75 WWOX 51741
Affinity Capture-MS Homo sapiens
76 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
77 LCK 3932
Proximity Label-MS Homo sapiens
78 NSA2  
Affinity Capture-MS Homo sapiens
79 CAV1 857
Proximity Label-MS Homo sapiens
80 C11orf52 91894
Proximity Label-MS Homo sapiens
81 BRK1 55845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 MMGT1 93380
Affinity Capture-MS Homo sapiens
83 PCNA 5111
Affinity Capture-MS Homo sapiens
84 KHDRBS2  
Affinity Capture-MS Homo sapiens
85 ABI2 10152
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 Samhd1 56045
Affinity Capture-MS Mus musculus
87 C1QBP 708
Affinity Capture-MS Homo sapiens
88 KRAS 3845
Proximity Label-MS Homo sapiens
89 CYFIP1 23191
Affinity Capture-MS Homo sapiens
90 STRN 6801
Affinity Capture-MS Homo sapiens
91 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KIAA1522 is involved
No pathways found





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