Gene description for PDZK1IP1
Gene name PDZK1 interacting protein 1
Gene symbol PDZK1IP1
Other names/aliases DD96
MAP17
SPAP
Species Homo sapiens
 Database cross references - PDZK1IP1
ExoCarta ExoCarta_10158
Vesiclepedia VP_10158
Entrez Gene 10158
HGNC 16887
MIM 607178
UniProt Q13113  
 PDZK1IP1 identified in exosomes derived from the following tissue/cell type
Pancreatic duct fluid 29339034    
Pancreatic duct fluid 29339034    
Pancreatic duct fluid 29339034    
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for PDZK1IP1
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    apical plasma membrane GO:0016324 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PDZK1IP1 in exosomes
1
Experiment ID 622
MISEV standards
EM
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with Pancreatic ductal adenocarcinoma
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 623
MISEV standards
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with IPMN with microinvasive cancer (IPMNca)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 625
MISEV standards
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with benign pancreatic disease
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 13
MISEV standards
IEM
Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
5
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PDZK1IP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AQP2 359
Two-hybrid Homo sapiens
2 EMC6 83460
Two-hybrid Homo sapiens
3 GYPA  
Two-hybrid Homo sapiens
4 TMEM14C 51522
Two-hybrid Homo sapiens
5 TMEM107 84314
Two-hybrid Homo sapiens
6 PEX16 9409
Two-hybrid Homo sapiens
7 CYB5B 80777
Two-hybrid Homo sapiens
8 UTP14A 10813
Two-hybrid Homo sapiens
9 UPK1B 7348
Two-hybrid Homo sapiens
10 SLC35B1 10237
Two-hybrid Homo sapiens
11 MIP  
Two-hybrid Homo sapiens
12 STX12 23673
Two-hybrid Homo sapiens
13 C14orf1 11161
Two-hybrid Homo sapiens
14 TMEM39B  
Two-hybrid Homo sapiens
15 YIPF6 286451
Two-hybrid Homo sapiens
16 RTP2  
Two-hybrid Homo sapiens
17 THBD 7056
Two-hybrid Homo sapiens
18 COPS6 10980
Two-hybrid Homo sapiens
19 ZDHHC17 23390
Two-hybrid Homo sapiens
20 LOC100507537  
Two-hybrid Homo sapiens
21 ASGR1 432
Two-hybrid Homo sapiens
22 FCER1G 2207
Two-hybrid Homo sapiens
23 FAM3C 10447
Two-hybrid Homo sapiens
24 GAST  
Two-hybrid Homo sapiens
25 TMEM14B  
Two-hybrid Homo sapiens
26 ICMT  
Two-hybrid Homo sapiens
27 TMEM203  
Two-hybrid Homo sapiens
28 PPAPDC1A  
Two-hybrid Homo sapiens
29 AIG1  
Two-hybrid Homo sapiens
30 NSG1  
Two-hybrid Homo sapiens
31 IGFBP5 3488
Two-hybrid Homo sapiens
32 TMEM11 8834
Two-hybrid Homo sapiens
33 JAGN1 84522
Two-hybrid Homo sapiens
34 MYADML2  
Two-hybrid Homo sapiens
35 APOD 347
Two-hybrid Homo sapiens
36 TRIM54  
Two-hybrid Homo sapiens
37 MYADM 91663
Two-hybrid Homo sapiens
38 SFTPC  
Two-hybrid Homo sapiens
39 AGR3 155465
Two-hybrid Homo sapiens
40 CD81 975
Two-hybrid Homo sapiens
41 ARL13B 200894
Two-hybrid Homo sapiens
42 TNFRSF10C  
Two-hybrid Homo sapiens
43 NUMB 8650
Two-hybrid Homo sapiens
44 SDCBP 6386
Two-hybrid Homo sapiens
45 RPRM  
Two-hybrid Homo sapiens
46 APOA2 336
Two-hybrid Homo sapiens
47 TMEM109 79073
Two-hybrid Homo sapiens
48 GRM2 2912
Two-hybrid Homo sapiens
49 SFXN2  
Two-hybrid Homo sapiens
50 TMEM86A  
Two-hybrid Homo sapiens
51 PMP22  
Two-hybrid Homo sapiens
52 PGAP2  
Two-hybrid Homo sapiens
53 TMEM65 157378
Two-hybrid Homo sapiens
54 GALNT15  
Two-hybrid Homo sapiens
55 PLP2 5355
Two-hybrid Homo sapiens
56 C2CD2L 9854
Two-hybrid Homo sapiens
57 PPAPDC2  
Two-hybrid Homo sapiens
58 C14orf180  
Two-hybrid Homo sapiens
59 PDZK1 5174
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
60 CLDN19  
Two-hybrid Homo sapiens
61 LHFPL5  
Two-hybrid Homo sapiens
62 C17orf62 79415
Two-hybrid Homo sapiens
63 TSPO2  
Two-hybrid Homo sapiens
64 SLC35B4  
Two-hybrid Homo sapiens
65 GIMAP5  
Two-hybrid Homo sapiens
66 CES1  
Two-hybrid Homo sapiens
67 TMEM97 27346
Two-hybrid Homo sapiens
68 TUSC5  
Two-hybrid Homo sapiens
69 TMEM140  
Two-hybrid Homo sapiens
70 LEPROTL1 23484
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PDZK1IP1 is involved
No pathways found





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