Gene description for KCTD10
Gene name potassium channel tetramerization domain containing 10
Gene symbol KCTD10
Other names/aliases BTBD28
MSTP028
ULRO61
hBACURD3
Species Homo sapiens
 Database cross references - KCTD10
ExoCarta ExoCarta_83892
Vesiclepedia VP_83892
Entrez Gene 83892
HGNC 23236
MIM 613421
UniProt Q9H3F6  
 KCTD10 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for KCTD10
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IBA
    ubiquitin-protein transferase activity GO:0004842 ISS
    Notch binding GO:0005112 IPI
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IEA
    protein ubiquitination GO:0016567 ISS
    negative regulation of Rho protein signal transduction GO:0035024 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    Cul3-RING ubiquitin ligase complex GO:0031463 IBA
    Cul3-RING ubiquitin ligase complex GO:0031463 ISS
 Experiment description of studies that identified KCTD10 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KCTD10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
3 CKAP4 10970
Affinity Capture-MS Homo sapiens
4 KIF23 9493
Affinity Capture-MS Homo sapiens
5 FMNL1 752
Affinity Capture-MS Homo sapiens
6 NPLOC4 55666
Affinity Capture-MS Homo sapiens
7 STT3A 3703
Affinity Capture-MS Homo sapiens
8 ATP6V1A 523
Affinity Capture-MS Homo sapiens
9 MARCKS 4082
Affinity Capture-MS Homo sapiens
10 USP13  
Affinity Capture-MS Homo sapiens
11 KCTD10 83892
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
12 TEX11  
Two-hybrid Homo sapiens
13 DBN1 1627
Affinity Capture-MS Homo sapiens
14 Cul3  
Affinity Capture-MS Mus musculus
15 UBC 7316
Affinity Capture-MS Homo sapiens
16 DVL3 1857
Two-hybrid Homo sapiens
17 HNRNPR 10236
Affinity Capture-MS Homo sapiens
18 CELA2A  
Affinity Capture-MS Homo sapiens
19 NELFA  
Affinity Capture-MS Homo sapiens
20 Actb 11461
Affinity Capture-MS Mus musculus
21 UTP3 57050
Affinity Capture-MS Homo sapiens
22 APOD 347
Affinity Capture-MS Homo sapiens
23 KIR3DL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 HOXB6 3216
Affinity Capture-MS Homo sapiens
25 LMO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 UTRN 7402
Affinity Capture-MS Homo sapiens
27 TKT 7086
Affinity Capture-MS Homo sapiens
28 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
29 SV2A 9900
Affinity Capture-MS Homo sapiens
30 MTURN  
Affinity Capture-MS Homo sapiens
31 HOXA5  
Affinity Capture-MS Homo sapiens
32 COPS6 10980
Affinity Capture-MS Homo sapiens
33 USP39 10713
Affinity Capture-MS Homo sapiens
34 VEGFB  
Affinity Capture-MS Homo sapiens
35 COPS5 10987
Affinity Capture-MS Homo sapiens
36 PVR 5817
Affinity Capture-MS Homo sapiens
37 SOST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TOM1 10043
Affinity Capture-MS Homo sapiens
39 ABCE1 6059
Affinity Capture-MS Homo sapiens
40 SNX1 6642
Affinity Capture-MS Homo sapiens
41 HSPA7 3311
Affinity Capture-MS Homo sapiens
42 SCARB1 949
Affinity Capture-MS Homo sapiens
43 FAF1 11124
Affinity Capture-MS Homo sapiens
44 PDIA6 10130
Affinity Capture-MS Homo sapiens
45 STXBP3 6814
Affinity Capture-MS Homo sapiens
46 ATG16L1 55054
Affinity Capture-MS Homo sapiens
47 CCDC130  
Affinity Capture-MS Homo sapiens
48 MECP2 4204
Affinity Capture-MS Homo sapiens
49 MAVS 57506
Affinity Capture-MS Homo sapiens
50 CPT2 1376
Affinity Capture-MS Homo sapiens
51 PLS3 5358
Affinity Capture-MS Homo sapiens
52 KCTD13 253980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
53 Lima1  
Affinity Capture-MS Mus musculus
54 KIF14 9928
Affinity Capture-MS Homo sapiens
55 ATAD3A 55210
Affinity Capture-MS Homo sapiens
56 RABGEF1 27342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 GALNT1 2589
Affinity Capture-MS Homo sapiens
58 KDM8  
Affinity Capture-MS Homo sapiens
59 NELFB 25920
Affinity Capture-MS Homo sapiens
60 RAD23B 5887
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MYO18A 399687
Affinity Capture-MS Homo sapiens
62 RBX1 9978
Affinity Capture-MS Homo sapiens
63 WASF2 10163
Affinity Capture-MS Homo sapiens
64 ACADVL 37
Affinity Capture-MS Homo sapiens
65 TCEA2  
Two-hybrid Homo sapiens
66 RPL19 6143
Affinity Capture-MS Homo sapiens
67 STIP1 10963
Affinity Capture-MS Homo sapiens
68 ODF3L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 POC1A  
Affinity Capture-MS Homo sapiens
70 WDYHV1  
Two-hybrid Homo sapiens
71 DDX5 1655
Affinity Capture-MS Homo sapiens
72 ATXN3 4287
Affinity Capture-MS Homo sapiens
73 CCDC157  
Affinity Capture-MS Homo sapiens
74 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
75 PPP1R21 129285
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 PCLO 27445
Affinity Capture-MS Homo sapiens
77 SPATS2  
Affinity Capture-MS Homo sapiens
78 ACTB 60
Affinity Capture-MS Homo sapiens
79 CEP76  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 AGPS 8540
Affinity Capture-MS Homo sapiens
81 PPM1G 5496
Affinity Capture-MS Homo sapiens
82 CTNNBL1 56259
Affinity Capture-MS Homo sapiens
83 PAPSS2 9060
Affinity Capture-MS Homo sapiens
84 IRGQ 126298
Affinity Capture-MS Homo sapiens
85 ANLN 54443
Affinity Capture-MS Homo sapiens
86 NT5E 4907
Affinity Capture-MS Homo sapiens
87 LIMA1 51474
Affinity Capture-MS Homo sapiens
88 PTPN11 5781
Affinity Capture-MS Homo sapiens
89 RBM39 9584
Affinity Capture-MS Homo sapiens
90 SF1 7536
Affinity Capture-MS Homo sapiens
91 Myh9 17886
Affinity Capture-MS Mus musculus
92 Cd2ap 12488
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
93 STXBP2 6813
Affinity Capture-MS Homo sapiens
94 GLMN 11146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 ECT2 1894
Affinity Capture-MS Homo sapiens
96 UBXN7 26043
Affinity Capture-MS Homo sapiens
97 STXBP1 6812
Affinity Capture-MS Homo sapiens
98 LMNB2 84823
Affinity Capture-MS Homo sapiens
99 TBX20 57057
Affinity Capture-MS Homo sapiens
100 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
102 MAB21L2  
Affinity Capture-MS Homo sapiens
103 MAP3K7  
Affinity Capture-MS Homo sapiens
104 MYO1C 4641
Affinity Capture-MS Homo sapiens
105 TOMM70A 9868
Affinity Capture-MS Homo sapiens
106 FARSB 10056
Affinity Capture-MS Homo sapiens
107 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
108 LSM3 27258
Affinity Capture-MS Homo sapiens
109 LMNB1 4001
Affinity Capture-MS Homo sapiens
110 EPN3 55040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 SDHA 6389
Affinity Capture-MS Homo sapiens
112 ADAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 KALRN 8997
Affinity Capture-MS Homo sapiens
114 RPN1 6184
Affinity Capture-MS Homo sapiens
115 Junb  
Affinity Capture-MS Mus musculus
116 DCX  
Affinity Capture-MS Homo sapiens
117 RNF2  
Affinity Capture-MS Homo sapiens
118 Kctd5  
Affinity Capture-MS Mus musculus
119 XRCC3  
Affinity Capture-MS Homo sapiens
120 FAM188A 80013
Affinity Capture-MS Homo sapiens
121 DLAT 1737
Affinity Capture-MS Homo sapiens
122 LMNA 4000
Affinity Capture-MS Homo sapiens
123 UBXN1 51035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 GNL3 26354
Affinity Capture-MS Homo sapiens
125 FAM133A 286499
Affinity Capture-MS Homo sapiens
126 EIF3D 8664
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
127 EEF1A1 1915
Affinity Capture-MS Homo sapiens
128 ZRANB1 54764
Affinity Capture-MS Homo sapiens
129 SURF6  
Affinity Capture-MS Homo sapiens
130 NRP1 8829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 PRKCSH 5589
Affinity Capture-MS Homo sapiens
132 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
133 HSPB2  
Affinity Capture-MS Homo sapiens
134 YTHDF2 51441
Affinity Capture-MS Homo sapiens
135 USP25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 CPSF6 11052
Affinity Capture-MS Homo sapiens
137 GBP1 2633
Affinity Capture-MS Homo sapiens
138 RPL6 6128
Affinity Capture-MS Homo sapiens
139 IREB2 3658
Affinity Capture-MS Homo sapiens
140 TNFAIP1 7126
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
141 FXR1 8087
Affinity Capture-MS Homo sapiens
142 KRT10 3858
Affinity Capture-MS Homo sapiens
143 IRF2BP2  
Affinity Capture-MS Homo sapiens
144 CFAP36 112942
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 SETD3 84193
Affinity Capture-MS Homo sapiens
146 CAPZA2 830
Affinity Capture-MS Homo sapiens
147 FKBP9 11328
Affinity Capture-MS Homo sapiens
148 LY6G6F 259215
Affinity Capture-MS Homo sapiens
149 SNX2 6643
Affinity Capture-MS Homo sapiens
150 EPN2 22905
Affinity Capture-MS Homo sapiens
151 EDEM2  
Affinity Capture-MS Homo sapiens
152 YTHDF3  
Affinity Capture-MS Homo sapiens
153 PCNA 5111
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
154 ITSN2 50618
Two-hybrid Homo sapiens
155 PDLIM5 10611
Affinity Capture-MS Homo sapiens
156 NCL 4691
Affinity Capture-MS Homo sapiens
157 HNRNPL 3191
Affinity Capture-MS Homo sapiens
158 AIFM1 9131
Affinity Capture-MS Homo sapiens
159 FLNA 2316
Affinity Capture-MS Homo sapiens
160 GPC3 2719
Affinity Capture-MS Homo sapiens
161 CIT 11113
Affinity Capture-MS Homo sapiens
162 KXD1 79036
Affinity Capture-MS Homo sapiens
163 SNW1 22938
Affinity Capture-MS Homo sapiens
164 RBBP5 5929
Affinity Capture-MS Homo sapiens
165 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 RPA1 6117
Affinity Capture-MS Homo sapiens
167 Copa 12847
Affinity Capture-MS Mus musculus
168 CDKN2AIP  
Affinity Capture-MS Homo sapiens
169 EXOSC1 51013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 AGRP  
Affinity Capture-MS Homo sapiens
171 NEDD8 4738
Affinity Capture-MS Homo sapiens
172 FUBP3 8939
Affinity Capture-MS Homo sapiens
173 ARIH1 25820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KCTD10 is involved
No pathways found





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