Gene description for SNRPG
Gene name small nuclear ribonucleoprotein polypeptide G
Gene symbol SNRPG
Other names/aliases SMG
Sm-G
Species Homo sapiens
 Database cross references - SNRPG
ExoCarta ExoCarta_6637
Entrez Gene 6637
HGNC 11163
MIM 603542
UniProt P62308  
 SNRPG identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for SNRPG
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    termination of RNA polymerase II transcription GO:0006369 TAS
    RNA splicing GO:0008380 TAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    spliceosomal snRNP assembly GO:0000387 TAS
    ncRNA metabolic process GO:0034660 TAS
    gene expression GO:0010467 TAS
    spliceosomal complex assembly GO:0000245 NAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    histone mRNA metabolic process GO:0008334 TAS
    mRNA 3'-end processing GO:0031124 TAS
Subcellular Localization
    SMN-Sm protein complex GO:0034719 IDA
    cytosol GO:0005829 TAS
    small nuclear ribonucleoprotein complex GO:0030532 NAS
    methylosome GO:0034709 IDA
    U7 snRNP GO:0005683 IDA
    catalytic step 2 spliceosome GO:0071013 IDA
    U1 snRNP GO:0005685 IDA
    U4 snRNP GO:0005687 IDA
    nucleoplasm GO:0005654 TAS
    small nucleolar ribonucleoprotein complex GO:0005732 IEA
    spliceosomal complex GO:0005681 TAS
    U12-type spliceosomal complex GO:0005689 IDA
 Experiment description of studies that identified SNRPG in exosomes
1
Experiment ID 207
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNRPG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD2BP2 10421
Affinity Capture-MS Homo sapiens
2 RNU11 26824
Affinity Capture-MS Homo sapiens
3 TACC1 6867
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 GEMIN5 25929
Reconstituted Complex Homo sapiens
5 GDF9 2661
Two-hybrid Homo sapiens
6 RNU12  
Affinity Capture-MS Homo sapiens
7 CRMP1 1400
Two-hybrid Homo sapiens
8 VCL 7414
Affinity Capture-MS Homo sapiens
9 SNRPE 6635
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 TLE1  
Two-hybrid Homo sapiens
11 DDX20  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
12 SMN2 6607
Invitro Homo sapiens
13 C14orf1 11161
Two-hybrid Homo sapiens
14 KIAA1377  
Two-hybrid Homo sapiens
15 COPS6 10980
Two-hybrid Homo sapiens
16 DDIT4L  
Two-hybrid Homo sapiens
17 SNRPD3 6634
Two-hybrid Homo sapiens
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