Gene description for CASP3
Gene name caspase 3, apoptosis-related cysteine peptidase
Gene symbol CASP3
Other names/aliases CPP32
CPP32B
SCA-1
Species Homo sapiens
 Database cross references - CASP3
ExoCarta ExoCarta_836
Vesiclepedia VP_836
Entrez Gene 836
HGNC 1504
MIM 600636
UniProt P42574  
 CASP3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
 Gene ontology annotations for CASP3
Molecular Function
    protease binding GO:0002020 IEA
    aspartic-type endopeptidase activity GO:0004190 IEA
    cysteine-type endopeptidase activity GO:0004197 IBA
    cysteine-type endopeptidase activity GO:0004197 IDA
    cysteine-type endopeptidase activity GO:0004197 IMP
    cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 IEA
    death receptor binding GO:0005123 IEA
    protein binding GO:0005515 IPI
    enzyme activator activity GO:0008047 IBA
    peptidase activity GO:0008233 IDA
    phospholipase A2 activator activity GO:0016005 IEA
    protein-containing complex binding GO:0044877 IEA
Biological Process
    luteolysis GO:0001554 IEA
    response to hypoxia GO:0001666 IEA
    B cell homeostasis GO:0001782 IEA
    negative regulation of cytokine production GO:0001818 IMP
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IDA
    apoptotic process GO:0006915 IBA
    apoptotic process GO:0006915 IDA
    apoptotic process GO:0006915 IMP
    DNA damage response GO:0006974 IEA
    axonal fasciculation GO:0007413 IEA
    heart development GO:0007507 IEA
    sensory perception of sound GO:0007605 IEA
    learning or memory GO:0007611 IEA
    intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    response to UV GO:0009411 IEA
    response to wounding GO:0009611 IEA
    response to glucose GO:0009749 IEA
    response to X-ray GO:0010165 IEA
    regulation of macroautophagy GO:0016241 TAS
    protein processing GO:0016485 IDA
    hippocampus development GO:0021766 IEA
    protein catabolic process GO:0030163 IDA
    neuron differentiation GO:0030182 IBA
    keratinocyte differentiation GO:0030216 IBA
    erythrocyte differentiation GO:0030218 IBA
    erythrocyte differentiation GO:0030218 IDA
    erythrocyte differentiation GO:0030218 TAS
    platelet formation GO:0030220 TAS
    negative regulation of B cell proliferation GO:0030889 IEA
    regulation of protein stability GO:0031647 IDA
    response to cobalt ion GO:0032025 IEA
    response to estradiol GO:0032355 IEA
    response to lipopolysaccharide GO:0032496 IEA
    glial cell apoptotic process GO:0034349 IEA
    response to tumor necrosis factor GO:0034612 TAS
    response to nicotine GO:0035094 IEA
    response to hydrogen peroxide GO:0042542 IEA
    T cell homeostasis GO:0043029 IEA
    response to amino acid GO:0043200 IEA
    positive regulation of neuron apoptotic process GO:0043525 IBA
    fibroblast apoptotic process GO:0044346 IEA
    cell fate commitment GO:0045165 IEA
    negative regulation of cell cycle GO:0045786 IEA
    negative regulation of activated T cell proliferation GO:0046007 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 IDA
    striated muscle cell differentiation GO:0051146 IEA
    response to glucocorticoid GO:0051384 IEA
    neuron apoptotic process GO:0051402 IEA
    protein maturation GO:0051604 IDA
    anterior neural tube closure GO:0061713 IEA
    pyroptotic inflammatory response GO:0070269 IDA
    leukocyte apoptotic process GO:0071887 IEA
    cellular response to staurosporine GO:0072734 IMP
    apoptotic signaling pathway GO:0097190 TAS
    intrinsic apoptotic signaling pathway GO:0097193 IMP
    execution phase of apoptosis GO:0097194 IBA
    execution phase of apoptosis GO:0097194 IDA
    execution phase of apoptosis GO:0097194 IGI
    execution phase of apoptosis GO:0097194 IMP
    regulation of synaptic vesicle cycle GO:0098693 IEA
    positive regulation of pyroptotic inflammatory response GO:0140639 IDA
    positive regulation of amyloid-beta formation GO:1902004 IDA
    epithelial cell apoptotic process GO:1904019 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    postsynaptic density GO:0014069 IEA
    death-inducing signaling complex GO:0031264 IBA
    neuronal cell body GO:0043025 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified CASP3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CASP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 GATA1  
Biochemical Activity Homo sapiens
3 GMNN  
Biochemical Activity Homo sapiens
4 XIAP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SLC35A1 10559
Affinity Capture-MS Homo sapiens
6 MED20 9477
Affinity Capture-MS Homo sapiens
7 TNFSF10 8743
Biochemical Activity Homo sapiens
8 NDUFS1 4719
Biochemical Activity Homo sapiens
9 SP1  
Biochemical Activity Homo sapiens
10 PAK2 5062
Co-localization Homo sapiens
11 GRIPAP1 56850
Biochemical Activity Homo sapiens
12 AKT3  
Co-localization Homo sapiens
13 TRUB1 142940
Co-fractionation Homo sapiens
14 LCMT1 51451
Co-fractionation Homo sapiens
15 PRKDC 5591
Biochemical Activity Homo sapiens
16 APP 351
Co-localization Homo sapiens
17 ARHGDIA 396
Biochemical Activity Homo sapiens
18 SNRNP70 6625
Biochemical Activity Homo sapiens
19 USO1 8615
Biochemical Activity Homo sapiens
20 CASP3 836
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
21 COPS6 10980
Biochemical Activity Homo sapiens
22 GLRX 2745
Two-hybrid Homo sapiens
23 MDC1  
Biochemical Activity Homo sapiens
24 YWHAG 7532
Two-hybrid Homo sapiens
25 ARMT1 79624
Co-fractionation Homo sapiens
26 SOCS5  
Two-hybrid Homo sapiens
27 RAD51  
Co-localization Homo sapiens
28 BIRC3 330
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
29 ATG4D  
Biochemical Activity Homo sapiens
30 RAB12 201475
Co-fractionation Homo sapiens
31 BTRC 8945
Affinity Capture-Western Homo sapiens
32 CFLAR  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
33 SAMHD1 25939
Co-fractionation Homo sapiens
34 Gzmb  
Biochemical Activity Mus musculus
35 GMDS 2762
Co-fractionation Homo sapiens
36 RBX1 9978
Affinity Capture-Western Homo sapiens
37 LSM14B 149986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CDKN1A  
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
39 ZBTB16  
Biochemical Activity Homo sapiens
40 BLM 641
Biochemical Activity Homo sapiens
41 HEY2  
Affinity Capture-Western Homo sapiens
42 MAPT  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
43 MKRN2 23609
Affinity Capture-RNA Homo sapiens
44 SREBF2 6721
Biochemical Activity Homo sapiens
45 CASP6 839
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
46 SERPINB8 5271
Co-fractionation Homo sapiens
47 CTNNB1 1499
Co-localization Homo sapiens
48 CDH1 999
Co-localization Homo sapiens
49 PKN1 5585
Biochemical Activity Homo sapiens
50 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
51 BECN1 8678
Biochemical Activity Homo sapiens
52 BMX  
Biochemical Activity Homo sapiens
53 MAPK8 5599
Biochemical Activity Homo sapiens
54 HCLS1 3059
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
55 BAG3 9531
Co-fractionation Homo sapiens
56 BIRC2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
57 STK3 6788
Co-localization Homo sapiens
58 BAX 581
Co-fractionation Homo sapiens
59 CRYAB 1410
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 EEF2 1938
Co-fractionation Homo sapiens
61 CASP2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
62 DBNL 28988
Biochemical Activity Homo sapiens
63 CTTN 2017
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
64 EIF4E 1977
Affinity Capture-MS Homo sapiens
65 PDPK1 5170
Affinity Capture-MS Homo sapiens
66 TRAF3 7187
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
67 CDC42 998
Co-localization Homo sapiens
68 FBXW11  
Affinity Capture-Western Homo sapiens
69 BIRC6 57448
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
FRET Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
70 STAT1 6772
Biochemical Activity Homo sapiens
71 RPA3 6119
Proximity Label-MS Homo sapiens
72 SOHLH1  
Two-hybrid Homo sapiens
73 CASP10  
Biochemical Activity Homo sapiens
74 DCC  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
75 MET 4233
Co-localization Homo sapiens
76 RNF2  
Biochemical Activity Homo sapiens
77 STK4 6789
Co-localization Homo sapiens
78 HSPD1 3329
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
79 MDM2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
80 BIRC5  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
81 GSN 2934
Biochemical Activity Homo sapiens
82 HSPE1 3336
Affinity Capture-Western Homo sapiens
83 MAP3K14  
Co-localization Homo sapiens
84 PARG 8505
Biochemical Activity Homo sapiens
85 SPTAN1 6709
Biochemical Activity Homo sapiens
86 PARP1 142
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
87 IDH3B 3420
Co-fractionation Homo sapiens
88 ROCK1 6093
Biochemical Activity Homo sapiens
89 CASP7  
Biochemical Activity Homo sapiens
90 ERP44 23071
Affinity Capture-MS Homo sapiens
91 PYGL 5836
Co-fractionation Homo sapiens
92 MCL1 4170
Biochemical Activity Homo sapiens
93 DFFA 1676
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
94 CASP8 841
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
95 BID  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
96 PTTG1  
Synthetic Growth Defect Homo sapiens
97 HSPB1 3315
Affinity Capture-Western Homo sapiens
98 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
99 MLH1 4292
Co-localization Homo sapiens
100 THAP11 57215
Two-hybrid Homo sapiens
101 CDK2 1017
Affinity Capture-MS Homo sapiens
102 GORASP1 64689
Biochemical Activity Homo sapiens
103 GZMB  
Biochemical Activity Homo sapiens
104 BCL2  
Biochemical Activity Homo sapiens
105 KCNA10  
Affinity Capture-MS Homo sapiens
106 MAPK9 5601
Biochemical Activity Homo sapiens
107 CASP9 842
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
108 SERBP1 26135
Affinity Capture-MS Homo sapiens
109 PTGES3 10728
Biochemical Activity Homo sapiens
110 BIRC7  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
111 VIM 7431
Biochemical Activity Homo sapiens
112 TRAF1 7185
Co-localization Homo sapiens
View the network image/svg+xml
 Pathways in which CASP3 is involved
PathwayEvidenceSource
Activation of caspases through apoptosome-mediated cleavage TAS Reactome
Apoptosis TAS Reactome
Apoptosis IEA Reactome
Apoptosis induced DNA fragmentation TAS Reactome
Apoptotic cleavage of cell adhesion proteins TAS Reactome
Apoptotic cleavage of cellular proteins TAS Reactome
Apoptotic execution phase TAS Reactome
Apoptotic execution phase IEA Reactome
Apoptotic factor-mediated response IEA Reactome
Apoptotic factor-mediated response TAS Reactome
Caspase activation via Dependence Receptors in the absence of ligand TAS Reactome
Caspase activation via Dependence Receptors in the absence of ligand IEA Reactome
Caspase activation via extrinsic apoptotic signalling pathway TAS Reactome
Caspase activation via extrinsic apoptotic signalling pathway IEA Reactome
Caspase-mediated cleavage of cytoskeletal proteins TAS Reactome
Cell death signalling via NRAGE, NRIF and NADE TAS Reactome
Cytochrome c-mediated apoptotic response TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Death Receptor Signaling TAS Reactome
Degradation of the extracellular matrix IEA Reactome
Extracellular matrix organization IEA Reactome
Immune System TAS Reactome
Intrinsic Pathway for Apoptosis IEA Reactome
Intrinsic Pathway for Apoptosis TAS Reactome
NADE modulates death signalling TAS Reactome
Other interleukin signaling TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
Programmed Cell Death TAS Reactome
Programmed Cell Death IEA Reactome
Pyroptosis TAS Reactome
Regulated Necrosis TAS Reactome
Signal Transduction TAS Reactome
Signaling by Hippo TAS Reactome
Signaling by Interleukins TAS Reactome
SMAC (DIABLO) binds to IAPs IEA Reactome
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes IEA Reactome
SMAC, XIAP-regulated apoptotic response IEA Reactome
SMAC, XIAP-regulated apoptotic response TAS Reactome
Stimulation of the cell death response by PAK-2p34 IEA Reactome





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