Gene description for BARD1
Gene name	BRCA1 associated RING domain 1
Gene symbol	BARD1
Other names/aliases	-
Species	Homo sapiens
Database cross references - BARD1
ExoCarta	ExoCarta_580
Vesiclepedia	VP_580
Entrez Gene	580
HGNC	952
MIM	601593
UniProt	Q99728
BARD1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for BARD1

Molecular Function     RNA binding GO:0003723 IDA     ubiquitin-protein transferase activity GO:0004842 IBA     ubiquitin-protein transferase activity GO:0004842 IDA     ubiquitin-protein transferase activity GO:0004842 NAS     protein binding GO:0005515 IPI     kinase binding GO:0019900 NAS     protein homodimerization activity GO:0042803 IPI     metal ion binding GO:0046872 IEA     protein heterodimerization activity GO:0046982 IPI     ubiquitin-modified histone reader activity GO:0061649 TAS     histone H2AK127 ubiquitin ligase activity GO:0140863 TAS     histone H2AK129 ubiquitin ligase activity GO:0140864 TAS Biological Process     tissue homeostasis GO:0001894 TAS     DNA repair GO:0006281 NAS     regulation of DNA repair GO:0006282 NAS     chromatin remodeling GO:0006338 TAS     regulation of transcription by RNA polymerase II GO:0006357 TAS     DNA damage response GO:0006974 NAS     protein ubiquitination GO:0016567 NAS     negative regulation of mRNA 3'-end processing GO:0031441 NAS     homologous recombination GO:0035825 NAS     regulation of phosphorylation GO:0042325 IMP     positive regulation of apoptotic process GO:0043065 IMP     negative regulation of apoptotic process GO:0043066 IMP     mitotic G2/M transition checkpoint GO:0044818 NAS     positive regulation of protein catabolic process GO:0045732 NAS     negative regulation of cell cycle GO:0045786 NAS     negative regulation of protein export from nucleus GO:0046826 IDA     regulation of cell cycle GO:0051726 NAS     cellular response to ionizing radiation GO:0071479 IMP     protein K6-linked ubiquitination GO:0085020 IBA     protein K6-linked ubiquitination GO:0085020 IDA     DNA strand resection involved in replication fork processing GO:0110025 NAS     regulation of DNA damage checkpoint GO:2000001 NAS Subcellular Localization     ubiquitin ligase complex GO:0000151 NAS     nuclear ubiquitin ligase complex GO:0000152 IDA     nucleus GO:0005634 IDA     nucleus GO:0005634 IMP     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     nuclear speck GO:0016607 IDA     BRCA1-BARD1 complex GO:0031436 IBA     BRCA1-BARD1 complex GO:0031436 IDA     BRCA1-BARD1 complex GO:0031436 IPI     cytoplasmic ribonucleoprotein granule GO:0036464 IDA     BRCA1-A complex GO:0070531 IBA     BRCA1-A complex GO:0070531 IDA     BRCA1-A complex GO:0070531 NAS     BRCA1-B complex GO:0070532 IPI     BRCA1-C complex GO:0070533 IPI