Gene description for RFC2
Gene name replication factor C (activator 1) 2, 40kDa
Gene symbol RFC2
Other names/aliases RFC40
Species Homo sapiens
 Database cross references - RFC2
ExoCarta ExoCarta_5982
Entrez Gene 5982
HGNC 9970
MIM 600404
UniProt P35250  
 RFC2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for RFC2
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    DNA clamp loader activity GO:0003689 IBA
Biological Process
    transcription-coupled nucleotide-excision repair GO:0006283 TAS
    DNA damage response, detection of DNA damage GO:0042769 TAS
    DNA repair GO:0006281 TAS
    nucleotide-excision repair, DNA gap filling GO:0006297 TAS
    DNA strand elongation involved in DNA replication GO:0006271 TAS
    error-free translesion synthesis GO:0070987 TAS
    mitotic cell cycle GO:0000278 TAS
    DNA-dependent DNA replication GO:0006261 IBA
    telomere maintenance via recombination GO:0000722 TAS
    base-excision repair GO:0006284 TAS
    nucleotide-excision repair GO:0006289 TAS
    translesion synthesis GO:0019985 TAS
    telomere maintenance via semi-conservative replication GO:0032201 TAS
    telomere maintenance GO:0000723 TAS
    DNA replication GO:0006260 TAS
    error-prone translesion synthesis GO:0042276 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    DNA replication factor C complex GO:0005663 IDA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified RFC2 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RFC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCNA 5111
Invitro Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
2 CHTF18 63922
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 DCC1  
Affinity Capture-Western Homo sapiens
4 RFC4 5984
Co-purification Homo sapiens
Co-purification Homo sapiens
5 RFC5 5985
Co-purification Homo sapiens
Co-purification Homo sapiens
6 RAD17  
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
8 BRD4 23476
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
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