Gene description for SRSF4
Gene name
serine/arginine-rich splicing factor 4
Gene symbol
SRSF4
Other names/aliases
SFRS4 SRP75
Species
Homo sapiens
Database cross references - SRSF4
ExoCarta
ExoCarta_6429
Entrez Gene
6429
HGNC
10786
MIM
601940
UniProt
Q08170
SRSF4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Gene ontology annotations for SRSF4
Experiment description of studies that identified SRSF4 in exosomes
1
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for SRSF4
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
SRRM1
Invivo
Homo sapiens
2
PNN
5411
Two-hybrid
Homo sapiens
Affinity Capture-Western
Homo sapiens
3
SRSF6
6431
Two-hybrid
Homo sapiens
4
HAP1
Two-hybrid
Homo sapiens
5
SFRS2IP
Two-hybrid
Homo sapiens
6
DYRK1A
Biochemical Activity
Homo sapiens
7
GEMIN2
8487
Two-hybrid
Homo sapiens
View the network
image/svg+xml
Pathways in which SRSF4 is involved