Gene description for HERC2
Gene name HECT and RLD domain containing E3 ubiquitin protein ligase 2
Gene symbol HERC2
Other names/aliases D15F37S1
MRT38
SHEP1
jdf2
p528
Species Homo sapiens
 Database cross references - HERC2
ExoCarta ExoCarta_8924
Vesiclepedia VP_8924
Entrez Gene 8924
HGNC 4868
MIM 605837
UniProt O95714  
 HERC2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for HERC2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 NAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    SUMO binding GO:0032183 IDA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    DNA repair GO:0006281 IEA
    intracellular protein transport GO:0006886 NAS
    DNA damage response GO:0006974 IDA
    spermatogenesis GO:0007283 IEA
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IEA
    neuron differentiation GO:0030182 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    negative regulation of Notch signaling pathway GO:0045746 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    centriole GO:0005814 IEA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
 Experiment description of studies that identified HERC2 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HERC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kif19a  
Affinity Capture-MS Mus musculus
2 EIF3A 8661
Affinity Capture-MS Homo sapiens
3 SLFN11 91607
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 CCDC151  
Affinity Capture-MS Homo sapiens
6 C5AR2  
Two-hybrid Homo sapiens
7 NUF2  
Affinity Capture-MS Homo sapiens
8 BIRC6 57448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 HOOK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 FAM98A 25940
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NPRL2  
Affinity Capture-Western Homo sapiens
12 PMS1  
Affinity Capture-Western Homo sapiens
13 AIPL1  
Affinity Capture-MS Homo sapiens
14 ZNF286A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EIF3C 8663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MRPL30  
Affinity Capture-MS Homo sapiens
17 EIF3K 27335
Affinity Capture-MS Homo sapiens
18 KIFC3 3801
Affinity Capture-MS Homo sapiens
19 RPA2 6118
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
20 SERPINB6 5269
Cross-Linking-MS (XL-MS) Homo sapiens
21 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
22 XPA  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
23 KIF20A 10112
Affinity Capture-MS Homo sapiens
24 MRPL10 124995
Affinity Capture-MS Homo sapiens
25 USP16  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
26 UBC 7316
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
27 LAMP2 3920
Proximity Label-MS Homo sapiens
28 CALM1 801
Reconstituted Complex Homo sapiens
29 PSMD10 5716
Affinity Capture-MS Homo sapiens
30 APBB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 RIPK1 8737
Affinity Capture-MS Homo sapiens
32 CCDC65  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 RMI1  
Affinity Capture-MS Homo sapiens
34 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 GCG  
Affinity Capture-MS Homo sapiens
36 PPL 5493
Affinity Capture-MS Homo sapiens
37 MRFAP1L1  
Affinity Capture-MS Homo sapiens
38 MARK2 2011
Affinity Capture-MS Homo sapiens
39 Eef1a1 13627
Affinity Capture-MS Mus musculus
40 B3GNT2 10678
Affinity Capture-MS Homo sapiens
41 RNF8  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 EIF3B 8662
Affinity Capture-MS Homo sapiens
43 Cep170  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
44 MRPL12 6182
Affinity Capture-MS Homo sapiens
45 MDC1  
Affinity Capture-Western Homo sapiens
46 Ankrd26  
Affinity Capture-MS Mus musculus
47 ETFA 2108
Co-fractionation Homo sapiens
48 SOST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RAB5B 5869
Affinity Capture-Western Homo sapiens
50 ZNF451 26036
Affinity Capture-MS Homo sapiens
51 RAB5A 5868
Affinity Capture-Western Homo sapiens
52 HERC2 8924
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
53 BRD4 23476
Affinity Capture-MS Homo sapiens
54 UCHL5 51377
Affinity Capture-MS Homo sapiens
55 DNAJC7 7266
Proximity Label-MS Homo sapiens
56 RMI2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
57 GTSE1 51512
Affinity Capture-MS Homo sapiens
58 SGOL1  
Affinity Capture-MS Homo sapiens
59 CTNNA1 1495
Proximity Label-MS Homo sapiens
60 GSK3B 2932
Affinity Capture-MS Homo sapiens
61 FBXL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
62 MRPS30 10884
Affinity Capture-MS Homo sapiens
63 AURKA 6790
Affinity Capture-MS Homo sapiens
64 INPP4A 3631
Co-fractionation Homo sapiens
65 PSMC2 5701
Affinity Capture-MS Homo sapiens
66 DBNL 28988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 RB1CC1 9821
Affinity Capture-MS Homo sapiens
68 PIAS4  
Affinity Capture-Western Homo sapiens
69 RABEP1 9135
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 HSP90B1 7184
Cross-Linking-MS (XL-MS) Homo sapiens
71 BLM 641
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
72 PSMC1 5700
Affinity Capture-MS Homo sapiens
73 MAPRE1 22919
Affinity Capture-MS Homo sapiens
74 PSMD14 10213
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
75 RNF115  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 EIF3E 3646
Affinity Capture-MS Homo sapiens
77 DNAJB8  
Proximity Label-MS Homo sapiens
78 KIF2B 84643
Affinity Capture-MS Homo sapiens
79 CHMP4B 128866
Affinity Capture-MS Homo sapiens
80 PSMD2 5708
Affinity Capture-MS Homo sapiens
81 BARD1 580
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
82 RNF168  
Affinity Capture-Western Homo sapiens
83 RNF166  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 NAT10 55226
Affinity Capture-MS Homo sapiens
85 PNMA2  
Affinity Capture-MS Homo sapiens
86 DNAJA1 3301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 BICD2 23299
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 MPDU1 9526
Affinity Capture-MS Homo sapiens
89 FEZF1  
Affinity Capture-MS Homo sapiens
90 KRT2 3849
Affinity Capture-MS Homo sapiens
91 Tnks2  
Affinity Capture-MS Mus musculus
92 HECTD1 25831
Affinity Capture-MS Homo sapiens
93 GRIN2A  
Affinity Capture-MS Homo sapiens
94 EIF3H 8667
Affinity Capture-MS Homo sapiens
95 DNAJB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 GET4 51608
Affinity Capture-MS Homo sapiens
97 RYBP  
Affinity Capture-MS Homo sapiens
98 NCOA4 8031
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
99 NEURL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 TUBB4B 10383
Affinity Capture-MS Homo sapiens
101 DISC1 27185
Affinity Capture-MS Homo sapiens
102 ECH1 1891
Affinity Capture-MS Homo sapiens
103 EIF3G 8666
Affinity Capture-MS Homo sapiens
104 UBE2N 7334
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
105 HSP90B2P  
Cross-Linking-MS (XL-MS) Homo sapiens
106 USP42  
Affinity Capture-MS Homo sapiens
107 MAP7 9053
Affinity Capture-MS Homo sapiens
108 MAP4 4134
Affinity Capture-MS Homo sapiens
109 UBE3A 7337
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ARRDC4  
Affinity Capture-MS Homo sapiens
111 ZCCHC10  
Affinity Capture-MS Homo sapiens
112 CLPP 8192
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
113 SIRT7  
Affinity Capture-MS Homo sapiens
114 Tnks  
Affinity Capture-MS Mus musculus
115 UBE2L3 7332
Reconstituted Complex Homo sapiens
116 CTNNB1 1499
Affinity Capture-MS Homo sapiens
117 CKAP2  
Affinity Capture-MS Homo sapiens
118 PMCH  
Affinity Capture-MS Homo sapiens
119 SRGAP2 23380
Affinity Capture-MS Homo sapiens
120 DUSP26 78986
Proximity Label-MS Homo sapiens
121 CCP110  
Affinity Capture-MS Homo sapiens
122 BTF3 689
Affinity Capture-MS Homo sapiens
123 EGFR 1956
Affinity Capture-MS Homo sapiens
124 ATRIP  
Affinity Capture-Western Homo sapiens
125 FARP2 9855
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 NCKAP5  
Affinity Capture-MS Homo sapiens
127 Mus81  
Affinity Capture-MS Mus musculus
128 TANK 10010
Affinity Capture-MS Homo sapiens
129 CDC42 998
Two-hybrid Homo sapiens
130 TOP3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
131 ECI2 10455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 CEP250 11190
Affinity Capture-MS Homo sapiens
133 MAPK6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 ARID3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 SPZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 HSDL2 84263
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 USP19 10869
Affinity Capture-MS Homo sapiens
138 NDC80 10403
Proximity Label-MS Homo sapiens
139 CDR2  
Affinity Capture-MS Homo sapiens
140 BICD1 636
Proximity Label-MS Homo sapiens
141 KTN1 3895
Affinity Capture-MS Homo sapiens
142 UBE2D2 7322
Reconstituted Complex Homo sapiens
143 CCDC88A 55704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 SIRT3  
Affinity Capture-MS Homo sapiens
145 MAP7D2 256714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 BDKRB2  
Two-hybrid Homo sapiens
147 ALS2CR11  
Affinity Capture-MS Homo sapiens
148 MRPL18 29074
Affinity Capture-MS Homo sapiens
149 CCDC8  
Affinity Capture-MS Homo sapiens
150 EIF3D 8664
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 UBE2D3 7323
Reconstituted Complex Homo sapiens
152 UBE2D1 7321
Reconstituted Complex Homo sapiens
153 ZRANB1 54764
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
154 ZNF669  
Affinity Capture-MS Homo sapiens
155 DNAJC28  
Proximity Label-MS Homo sapiens
156 EIF3F 8665
Affinity Capture-MS Homo sapiens
157 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
158 CLSPN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
159 SIRT6  
Affinity Capture-MS Homo sapiens
160 PDGFD 80310
Affinity Capture-MS Homo sapiens
161 ARRDC5  
Affinity Capture-MS Homo sapiens
162 SEC23IP 11196
Affinity Capture-MS Homo sapiens
163 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
164 CDK8 1024
Affinity Capture-MS Homo sapiens
165 PTRF 284119
Affinity Capture-MS Homo sapiens
166 EIF3I 8668
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
167 PRIMPOL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 HOXD13  
Affinity Capture-MS Homo sapiens
169 RPA1 6117
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
170 Cep135  
Affinity Capture-MS Mus musculus
171 KNOP1 400506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 WRN 7486
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
173 NHLRC2 374354
Affinity Capture-MS Homo sapiens
174 SAMD3  
Affinity Capture-MS Homo sapiens
175 FAM83H 286077
Affinity Capture-MS Homo sapiens
176 MAGEA9  
Affinity Capture-MS Homo sapiens
177 SIRT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
178 SSBP1 6742
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 SMC3 9126
Affinity Capture-MS Homo sapiens
180 TBK1 29110
Affinity Capture-MS Homo sapiens
181 RPS24 6229
Affinity Capture-MS Homo sapiens
182 GAPDH 2597
Cross-Linking-MS (XL-MS) Homo sapiens
183 EFCAB1  
Affinity Capture-MS Homo sapiens
184 EIF3M 10480
Affinity Capture-MS Homo sapiens
185 LRRK2 120892
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
186 STK33  
Affinity Capture-MS Homo sapiens
187 CEP135  
Proximity Label-MS Homo sapiens
188 APBA2 321
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 SSSCA1 10534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 HERC3 8916
Affinity Capture-MS Homo sapiens
191 STK11 6794
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
192 ERG  
Reconstituted Complex Homo sapiens
193 TXNIP 10628
Affinity Capture-MS Homo sapiens
194 CCDC136  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
195 MRPL53  
Affinity Capture-MS Homo sapiens
196 ATOH1  
Affinity Capture-MS Homo sapiens
197 PSMC4 5704
Affinity Capture-MS Homo sapiens
198 CEP170 9859
Affinity Capture-MS Homo sapiens
199 RPA3 6119
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
200 FAM63A 55793
Affinity Capture-MS Homo sapiens
201 USP20  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
202 EIF3L 51386
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens