Gene description for COG5
Gene name component of oligomeric golgi complex 5
Gene symbol COG5
Other names/aliases CDG2I
GOLTC1
GTC90
Species Homo sapiens
 Database cross references - COG5
ExoCarta ExoCarta_10466
Vesiclepedia VP_10466
Entrez Gene 10466
HGNC 14857
MIM 606821
UniProt Q9UP83  
 COG5 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for COG5
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    retrograde transport, vesicle recycling within Golgi GO:0000301 IMP
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    intra-Golgi vesicle-mediated transport GO:0006891 NAS
    Golgi organization GO:0007030 IMP
    protein transport GO:0015031 IEA
    inter-Golgi cisterna vesicle-mediated transport GO:0048219 IDA
    glycosylation GO:0070085 IMP
Subcellular Localization
    Golgi membrane GO:0000139 NAS
    Golgi membrane GO:0000139 TAS
    nucleoplasm GO:0005654 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IEA
    membrane GO:0016020 HDA
    Golgi transport complex GO:0017119 IBA
    Golgi transport complex GO:0017119 IDA
    Golgi transport complex GO:0017119 NAS
    trans-Golgi network membrane GO:0032588 TAS
 Experiment description of studies that identified COG5 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COG5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD40 958
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 OCIAD1 54940
Affinity Capture-MS Homo sapiens
4 CYB5B 80777
Affinity Capture-MS Homo sapiens
5 EFNA4  
Affinity Capture-MS Homo sapiens
6 EBAG9 9166
Proximity Label-MS Homo sapiens
7 RAB1A 5861
Synthetic Lethality Homo sapiens
8 LEO1 123169
Affinity Capture-MS Homo sapiens
9 GPR17 2840
Affinity Capture-MS Homo sapiens
10 MEFV  
Two-hybrid Homo sapiens
11 CCDC114  
Affinity Capture-MS Homo sapiens
12 CMTM8  
Affinity Capture-MS Homo sapiens
13 COMMD8 54951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 VSIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 FOXB1  
Affinity Capture-MS Homo sapiens
16 NPTN 27020
Affinity Capture-MS Homo sapiens
17 VSIG1  
Affinity Capture-MS Homo sapiens
18 APC  
Two-hybrid Homo sapiens
19 GPR182  
Affinity Capture-MS Homo sapiens
20 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 COG8 84342
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 C9orf78 51759
Affinity Capture-MS Homo sapiens
23 IFFO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 EGFR 1956
Affinity Capture-MS Homo sapiens
25 COG2 22796
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
26 FOXL1  
Affinity Capture-MS Homo sapiens
27 STX4 6810
Affinity Capture-MS Homo sapiens
28 ILVBL 10994
Affinity Capture-MS Homo sapiens
29 KRT27 342574
Affinity Capture-MS Homo sapiens
30 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 COG1 9382
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 COG6 57511
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 C12orf49  
Negative Genetic Homo sapiens
35 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 STK24 8428
Co-fractionation Homo sapiens
37 ARSF 416
Affinity Capture-MS Homo sapiens
38 RPA3 6119
Proximity Label-MS Homo sapiens
39 NIN 51199
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 VCP 7415
Affinity Capture-MS Homo sapiens
41 NTRK1 4914
Affinity Capture-MS Homo sapiens
42 TRAF5  
Affinity Capture-MS Homo sapiens
43 PCDHA4 56144
Affinity Capture-MS Homo sapiens
44 Poc1b  
Affinity Capture-MS Mus musculus
45 COG3 83548
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CCDC136  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PCM1 5108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RAC1 5879
Two-hybrid Homo sapiens
49 COG7 91949
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ATP7A 538
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 COG4 25839
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PARP16 54956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 TSSC1 7260
Synthetic Lethality Homo sapiens
54 TACSTD2 4070
Affinity Capture-MS Homo sapiens
55 Nek9  
Affinity Capture-MS Mus musculus
56 ITFG3 83986
Affinity Capture-MS Homo sapiens
57 PTAR1 375743
Synthetic Lethality Homo sapiens
View the network image/svg+xml



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