Gene description for MINPP1
Gene name multiple inositol-polyphosphate phosphatase 1
Gene symbol MINPP1
Other names/aliases HIPER1
MINPP2
MIPP
Species Homo sapiens
 Database cross references - MINPP1
ExoCarta ExoCarta_9562
Vesiclepedia VP_9562
Entrez Gene 9562
HGNC 7102
MIM 605391
UniProt Q9UNW1  
 MINPP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MINPP1
Molecular Function
    acid phosphatase activity GO:0003993 IBA
    inositol-hexakisphosphate phosphatase activity GO:0004446 IDA
    inositol-hexakisphosphate phosphatase activity GO:0004446 IMP
    protein binding GO:0005515 IPI
    4-phytase activity GO:0008707 IEA
    3-phytase activity GO:0016158 IEA
    inositol bisphosphate phosphatase activity GO:0016312 IDA
    inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity GO:0030351 IDA
    inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity GO:0030351 TAS
    inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity GO:0030352 IDA
    bisphosphoglycerate 3-phosphatase activity GO:0034417 IDA
    inositol trisphosphate phosphatase activity GO:0046030 IDA
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0051717 IDA
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0051717 TAS
    inositol phosphate phosphatase activity GO:0052745 IBA
    inositol phosphate phosphatase activity GO:0052745 NAS
    inositol hexakisphosphate 2-phosphatase activity GO:0052826 TAS
    inositol pentakisphosphate phosphatase activity GO:0052827 IMP
Biological Process
    ossification GO:0001503 NAS
    intracellular monoatomic cation homeostasis GO:0030003 IMP
    bone mineralization GO:0030282 NAS
    inositol phosphate metabolic process GO:0043647 TAS
Subcellular Localization
    extracellular space GO:0005615 IMP
    endoplasmic reticulum lumen GO:0005788 ISS
    endoplasmic reticulum lumen GO:0005788 TAS
    plasma membrane GO:0005886 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified MINPP1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MINPP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTP1 2950
Co-fractionation Homo sapiens
2 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PMPCA 23203
Co-fractionation Homo sapiens
4 PMPCB 9512
Co-fractionation Homo sapiens
5 PPP1CB 5500
Affinity Capture-MS Homo sapiens
6 TSFM 10102
Co-fractionation Homo sapiens
7 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
8 CALR3  
Proximity Label-MS Homo sapiens
9 PDIA4 9601
Proximity Label-MS Homo sapiens
10 LRRC59 55379
Proximity Label-MS Homo sapiens
11 UBQLN2 29978
Two-hybrid Homo sapiens
12 CD70 970
Affinity Capture-MS Homo sapiens
13 PDGFRA 5156
Affinity Capture-MS Homo sapiens
14 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EFNA5  
Affinity Capture-MS Homo sapiens
16 PRG2  
Affinity Capture-MS Homo sapiens
17 PPP5C 5536
Co-fractionation Homo sapiens
18 SOX4  
Two-hybrid Homo sapiens
19 EFNA4  
Affinity Capture-MS Homo sapiens
20 TMCO6  
Affinity Capture-MS Homo sapiens
21 CYP1A1  
Affinity Capture-MS Homo sapiens
22 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 UBE2V1 7335
Affinity Capture-MS Homo sapiens
24 SPINK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 MGAT2 4247
Affinity Capture-MS Homo sapiens
26 GDAP1 54332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GRHPR 9380
Co-fractionation Homo sapiens
28 CLEC12B  
Affinity Capture-MS Homo sapiens
29 C1orf87  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RPA3 6119
Proximity Label-MS Homo sapiens
31 FBXO2 26232
Affinity Capture-MS Homo sapiens
32 OGT 8473
Reconstituted Complex Homo sapiens
33 TPI1 7167
Co-fractionation Homo sapiens
34 IL27RA 9466
Affinity Capture-MS Homo sapiens
35 GIMAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 FOXRED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 LYPD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 NAT14 57106
Affinity Capture-MS Homo sapiens
39 VWA1 64856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 UBE2V2 7336
Affinity Capture-MS Homo sapiens
41 SEC61B 10952
Proximity Label-MS Homo sapiens
42 MRS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MINPP1 is involved
PathwayEvidenceSource
Inositol phosphate metabolism TAS Reactome
Metabolism TAS Reactome
Synthesis of IPs in the ER lumen TAS Reactome





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