Gene description for EDF1
Gene name endothelial differentiation-related factor 1
Gene symbol EDF1
Other names/aliases EDF-1
MBF1
Species Homo sapiens
 Database cross references - EDF1
ExoCarta ExoCarta_8721
Entrez Gene 8721
HGNC 3164
MIM 605107
UniProt O60869  
 EDF1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for EDF1
Molecular Function
    histone acetyltransferase activity GO:0004402 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IMP
    sequence-specific DNA binding GO:0043565 IEA
    transcription coactivator activity GO:0003713 IMP
    calmodulin binding GO:0005516 IEA
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    methyltransferase activity GO:0008168 IDA
Biological Process
    multicellular organismal development GO:0007275 IEA
    positive regulation of transcription, DNA-templated GO:0045893 TAS
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of DNA binding GO:0043388 IDA
    regulation of transcription, DNA-templated GO:0006355 TAS
    endothelial cell differentiation GO:0045446 TAS
    regulation of lipid metabolic process GO:0019216 TAS
Subcellular Localization
    nucleolus GO:0005730 IDA
    intracellular GO:0005622 TAS
    transcription factor TFIID complex GO:0005669 IDA
    cytoplasm GO:0005737 IMP
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 NAS
 Experiment description of studies that identified EDF1 in exosomes
1
Experiment ID 274
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for EDF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CALM2 805
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
2 NR5A2  
Reconstituted Complex Homo sapiens
3 TBP  
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
4 ATF2  
Invitro Homo sapiens
5 CALM3 808
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
6 NR1H3  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
7 RXRA  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
8 PPARG 5468
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
9 NR5A1  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
10 CALM1 801
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
11 CREB1  
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
12 ATF1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which EDF1 is involved
No pathways found





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