Gene description for CDC42EP3
Gene name CDC42 effector protein (Rho GTPase binding) 3
Gene symbol CDC42EP3
Other names/aliases BORG2
CEP3
UB1
Species Homo sapiens
 Database cross references - CDC42EP3
ExoCarta ExoCarta_10602
Entrez Gene 10602
HGNC 16943
MIM 606133
UniProt Q9UKI2  
 CDC42EP3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CDC42EP3
Molecular Function
    GTP-Rho binding GO:0017049 IBA
    GTPase activator activity GO:0005096 IBA
    cytoskeletal regulatory protein binding GO:0005519 TAS
Biological Process
    signal transduction GO:0007165 TAS
    positive regulation of pseudopodium assembly GO:0031274 IBA
    regulation of cell shape GO:0008360 IBA
    positive regulation of GTPase activity GO:0043547 IBA
    Rho protein signal transduction GO:0007266 IBA
    positive regulation of actin filament polymerization GO:0030838 IBA
Subcellular Localization
    actin cytoskeleton GO:0015629 IDA
    endomembrane system GO:0012505 IEA
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified CDC42EP3 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDC42EP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UMPS 7372
Two-hybrid Homo sapiens
2 CDC42 998
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
3 SEPT7 989
Reconstituted Complex Homo sapiens
4 CDC42EP3 10602
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 RHOQ 23433
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 SEPT6 23157
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CDC42EP3 is involved
No pathways found





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