Gene description for BICD2
Gene name bicaudal D homolog 2 (Drosophila)
Gene symbol BICD2
Other names/aliases SMALED2
bA526D8.1
Species Homo sapiens
 Database cross references - BICD2
ExoCarta ExoCarta_23299
Vesiclepedia VP_23299
Entrez Gene 23299
HGNC 17208
MIM 609797
UniProt Q8TD16  
 BICD2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for BICD2
Molecular Function
    protein binding GO:0005515 IPI
    cytoskeletal anchor activity GO:0008093 IEA
    small GTPase binding GO:0031267 ISS
    dynactin binding GO:0034452 IBA
    dynactin binding GO:0034452 ISS
    dynein light intermediate chain binding GO:0051959 IBA
    dynein complex binding GO:0070840 IBA
    dynein complex binding GO:0070840 ISS
Biological Process
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IMP
    microtubule-based movement GO:0007018 IBA
    protein transport GO:0015031 IEA
    protein localization to Golgi apparatus GO:0034067 IBA
    protein localization to Golgi apparatus GO:0034067 IMP
    mRNA transport GO:0051028 IEA
    centrosome localization GO:0051642 IMP
    regulation of microtubule cytoskeleton organization GO:0070507 IBA
    regulation of microtubule cytoskeleton organization GO:0070507 IGI
    minus-end-directed organelle transport along microtubule GO:0072385 ISS
    microtubule anchoring at microtubule organizing center GO:0072393 IBA
    microtubule anchoring at microtubule organizing center GO:0072393 ISS
Subcellular Localization
    nuclear envelope GO:0005635 IDA
    annulate lamellae GO:0005642 IDA
    nuclear pore GO:0005643 IDA
    cytoplasm GO:0005737 IMP
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    centrosome GO:0005813 IMP
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    cytoplasmic vesicle GO:0031410 ISS
 Experiment description of studies that identified BICD2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for BICD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARHGAP1 392
Proximity Label-MS Homo sapiens
2 PDAP1 11333
Proximity Label-MS Homo sapiens
3 ARPC2 10109
Proximity Label-MS Homo sapiens
4 DYNC1I2 1781
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
5 GAMT  
Proximity Label-MS Homo sapiens
6 MTMR14 64419
Proximity Label-MS Homo sapiens
7 MAP4K4 9448
Proximity Label-MS Homo sapiens
8 ST7  
Proximity Label-MS Homo sapiens
9 PMF1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
10 CAPN6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SEPT9 10801
Proximity Label-MS Homo sapiens
12 MOS 4342
Two-hybrid Homo sapiens
13 GPATCH1  
Proximity Label-MS Homo sapiens
14 PPP2R5D 5528
Proximity Label-MS Homo sapiens
15 CIAPIN1 57019
Proximity Label-MS Homo sapiens
16 ACTR3 10096
Proximity Label-MS Homo sapiens
17 NUP153 9972
Co-fractionation Homo sapiens
18 PPP1R18 170954
Two-hybrid Homo sapiens
19 CCDC138  
Proximity Label-MS Homo sapiens
20 CALD1 800
Proximity Label-MS Homo sapiens
21 ERC1 23085
Proximity Label-MS Homo sapiens
22 HSPH1 10808
Proximity Label-MS Homo sapiens
23 MTMR2 8898
Proximity Label-MS Homo sapiens
24 TFIP11  
Two-hybrid Homo sapiens
25 TMEM201 199953
Proximity Label-MS Homo sapiens
26 ORC6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SEPT8 23176
Proximity Label-MS Homo sapiens
28 HERC2 8924
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CHORDC1 26973
Proximity Label-MS Homo sapiens
30 ZNF598 90850
Proximity Label-MS Homo sapiens
31 FPGS 2356
Proximity Label-MS Homo sapiens
32 NMT1 4836
Proximity Label-MS Homo sapiens
33 CSDE1 7812
Proximity Label-MS Homo sapiens
34 SNX4 8723
Proximity Label-MS Homo sapiens
35 TES 26136
Proximity Label-MS Homo sapiens
36 SORBS1 10580
Proximity Label-MS Homo sapiens
37 LDHB 3945
Cross-Linking-MS (XL-MS) Homo sapiens
38 HN1L 90861
Proximity Label-MS Homo sapiens
39 TSGA10IP  
Two-hybrid Homo sapiens
40 UTP14A 10813
Two-hybrid Homo sapiens
41 DBNL 28988
Proximity Label-MS Homo sapiens
42 CAPZA1 829
Proximity Label-MS Homo sapiens
43 CEP41  
Proximity Label-MS Homo sapiens
44 LUZP1 7798
Proximity Label-MS Homo sapiens
45 CEP192 55125
Proximity Label-MS Homo sapiens
46 PSME1 5720
Proximity Label-MS Homo sapiens
47 MAPRE1 22919
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
48 CBR3 874
Two-hybrid Homo sapiens
49 XPOT 11260
Co-fractionation Homo sapiens
50 BICD2 23299
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
51 CSNK1E 1454
Proximity Label-MS Homo sapiens
52 PRPF18  
Two-hybrid Homo sapiens
53 UTP14C  
Two-hybrid Homo sapiens
54 VPS18 57617
Affinity Capture-MS Homo sapiens
55 CCDC85C  
Proximity Label-MS Homo sapiens
56 EIF3G 8666
Proximity Label-MS Homo sapiens
57 CNN3 1266
Proximity Label-MS Homo sapiens
58 FAM83B  
Proximity Label-MS Homo sapiens
59 HBS1L 10767
Proximity Label-MS Homo sapiens
60 CUL3 8452
Proximity Label-MS Homo sapiens
61 TTF2 8458
Proximity Label-MS Homo sapiens
62 SASS6 163786
Proximity Label-MS Homo sapiens
63 SNX9 51429
Proximity Label-MS Homo sapiens
64 IST1 9798
Proximity Label-MS Homo sapiens
65 MFAP1  
Two-hybrid Homo sapiens
66 RPA3 6119
Proximity Label-MS Homo sapiens
67 LTV1  
Proximity Label-MS Homo sapiens
68 EIF2D 1939
Proximity Label-MS Homo sapiens
69 CRTC1  
Proximity Label-MS Homo sapiens
70 NDC80 10403
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
71 ANKS1A 23294
Proximity Label-MS Homo sapiens
72 TCEANC  
Two-hybrid Homo sapiens
73 DPYSL3 1809
Proximity Label-MS Homo sapiens
74 PAIP1 10605
Proximity Label-MS Homo sapiens
75 PAFAH1B1 5048
Affinity Capture-Western Homo sapiens
76 ARPC3 10094
Proximity Label-MS Homo sapiens
77 TANK 10010
Proximity Label-MS Homo sapiens
78 COPZ1 22818
Proximity Label-MS Homo sapiens
79 BSDC1 55108
Proximity Label-MS Homo sapiens
80 TMEM57  
Proximity Label-MS Homo sapiens
81 PLEC 5339
Proximity Label-MS Homo sapiens
82 RGPD8  
Affinity Capture-MS Homo sapiens
83 PCMT1 5110
Proximity Label-MS Homo sapiens
84 C1orf123 54987
Affinity Capture-MS Homo sapiens
85 ZC2HC1A 51101
Proximity Label-MS Homo sapiens
86 DCTN2 10540
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
87 ARFIP2 23647
Proximity Label-MS Homo sapiens
88 RGPD1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
89 DYNC1H1 1778
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
90 TBK1 29110
Proximity Label-MS Homo sapiens
91 PIN1 5300
Proximity Label-MS Homo sapiens
92 PPP1R2 5504
Proximity Label-MS Homo sapiens
93 EIF4B 1975
Proximity Label-MS Homo sapiens
94 CEP135  
Proximity Label-MS Homo sapiens
95 RAB11A 8766
Proximity Label-MS Homo sapiens
96 KXD1 79036
Affinity Capture-MS Homo sapiens
97 PLEKHA7 144100
Proximity Label-MS Homo sapiens
98 LIMD1 8994
Proximity Label-MS Homo sapiens
99 SNW1 22938
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
100 UNC5CL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 MLLT4 4301
Proximity Label-MS Homo sapiens
102 RANGAP1 5905
Proximity Label-MS Homo sapiens
103 POC5  
Proximity Label-MS Homo sapiens
104 KLHL9 55958
Proximity Label-MS Homo sapiens
105 TRDMT1  
Proximity Label-MS Homo sapiens
106 EXOSC7 23016
Proximity Label-MS Homo sapiens
107 CAMSAP1 157922
Proximity Label-MS Homo sapiens
108 CLIP1 6249
Affinity Capture-MS Homo sapiens
109 AAK1 22848
Proximity Label-MS Homo sapiens
110 RBM22 55696
Two-hybrid Homo sapiens
111 PAWR 5074
Proximity Label-MS Homo sapiens
112 SH3GL1 6455
Proximity Label-MS Homo sapiens
113 ARFGAP2 84364
Proximity Label-MS Homo sapiens
114 NUP62 23636
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
115 DYNC1I1  
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
116 Ndc80  
Affinity Capture-MS Mus musculus
117 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 CLTB 1212
Proximity Label-MS Homo sapiens
119 CORO1B 57175
Proximity Label-MS Homo sapiens
120 EXOSC2 23404
Proximity Label-MS Homo sapiens
121 DPYSL2 1808
Proximity Label-MS Homo sapiens
122 TLN1 7094
Proximity Label-MS Homo sapiens
123 BORA  
Proximity Label-MS Homo sapiens
124 PRC1 9055
Two-hybrid Homo sapiens
125 TNIK 23043
Proximity Label-MS Homo sapiens
126 ACTR1A 10121
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
127 CCDC53 51019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 CNN2 1265
Proximity Label-MS Homo sapiens
129 SYNJ2 8871
Proximity Label-MS Homo sapiens
130 PTPN14 5784
Proximity Label-MS Homo sapiens
131 NFATC3 4775
Proximity Label-MS Homo sapiens
132 RAB6B 51560
Two-hybrid Homo sapiens
133 HSD17B4 3295
Proximity Label-MS Homo sapiens
134 PLS3 5358
Proximity Label-MS Homo sapiens
135 USP53 54532
Proximity Label-MS Homo sapiens
136 VRK3 51231
Affinity Capture-MS Homo sapiens
137 LCP1 3936
Proximity Label-MS Homo sapiens
138 MIB1 57534
Proximity Label-MS Homo sapiens
139 CEP55 55165
Proximity Label-MS Homo sapiens
140 FAM161B  
Two-hybrid Homo sapiens
141 TAB3 257397
Proximity Label-MS Homo sapiens
142 EIF2A 83939
Proximity Label-MS Homo sapiens
143 WRAP73 49856
Proximity Label-MS Homo sapiens
144 PPIP5K2 23262
Proximity Label-MS Homo sapiens
145 EFHD2 79180
Proximity Label-MS Homo sapiens
146 RPS6KB1 6198
Proximity Label-MS Homo sapiens
147 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
148 TJP2 9414
Proximity Label-MS Homo sapiens
149 PATL1 219988
Proximity Label-MS Homo sapiens
150 TMEM131  
Proximity Label-MS Homo sapiens
151 NFX1  
Proximity Label-MS Homo sapiens
152 SEPT6 23157
Proximity Label-MS Homo sapiens
153 PPP2R3A  
Proximity Label-MS Homo sapiens
154 NUP88 4927
Proximity Label-MS Homo sapiens
155 WHAMMP3  
Affinity Capture-MS Homo sapiens
156 STXBP5 134957
Proximity Label-MS Homo sapiens
157 XPO1 7514
Affinity Capture-MS Homo sapiens
158 USP15 9958
Proximity Label-MS Homo sapiens
159 TPR 7175
Co-fractionation Homo sapiens
160 FAM50B  
Two-hybrid Homo sapiens
161 TBCE 6905
Proximity Label-MS Homo sapiens
162 MIS18A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 TJP1 7082
Proximity Label-MS Homo sapiens
164 TUBB4B 10383
Affinity Capture-MS Homo sapiens
165 USP54 159195
Proximity Label-MS Homo sapiens
166 NUP43 348995
Proximity Label-MS Homo sapiens
167 CASP9 842
Proximity Label-MS Homo sapiens
168 NEFM 4741
Proximity Label-MS Homo sapiens
169 DYNC1LI1 51143
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
170 MICALL1 85377
Proximity Label-MS Homo sapiens
171 EDF1 8721
Proximity Label-MS Homo sapiens
172 PCM1 5108
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
173 LRCH2  
Proximity Label-MS Homo sapiens
174 MAP7D2 256714
Proximity Label-MS Homo sapiens
175 Plk1  
Affinity Capture-MS Mus musculus
176 PIN4 5303
Proximity Label-MS Homo sapiens
177 ZRANB1 54764
Affinity Capture-MS Homo sapiens
178 KRT18 3875
Proximity Label-MS Homo sapiens
179 ZNF669  
Two-hybrid Homo sapiens
180 FHL1 2273
Proximity Label-MS Homo sapiens
181 RRM2 6241
Proximity Label-MS Homo sapiens
182 ANXA2 302
Proximity Label-MS Homo sapiens
183 TTC1 7265
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
184 GPBP1  
Proximity Label-MS Homo sapiens
185 NXF1 10482
Two-hybrid Homo sapiens
186 CCHCR1  
Two-hybrid Homo sapiens
187 DPYSL5  
Proximity Label-MS Homo sapiens
188 RPP25L  
Proximity Label-MS Homo sapiens
189 BFSP1  
Affinity Capture-MS Homo sapiens
190 SIPA1L3  
Proximity Label-MS Homo sapiens
191 EIF4H 7458
Proximity Label-MS Homo sapiens
192 VPS33A 65082
Affinity Capture-MS Homo sapiens
193 ABI2 10152
Proximity Label-MS Homo sapiens
194 CDV3 55573
Proximity Label-MS Homo sapiens
195 KIAA0355 9710
Proximity Label-MS Homo sapiens
196 BCCIP 56647
Proximity Label-MS Homo sapiens
197 Ranbp2  
Affinity Capture-MS Mus musculus
198 DIS3L  
Proximity Label-MS Homo sapiens
199 NUDT5 11164
Proximity Label-MS Homo sapiens
200 RANBP2 5903
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
201 CC2D1A 54862
Proximity Label-MS Homo sapiens
202 MTMR6 9107
Proximity Label-MS Homo sapiens
203 SUFU 51684
Proximity Label-MS Homo sapiens
204 VPS41 27072
Affinity Capture-MS Homo sapiens
205 ZC3H7A  
Proximity Label-MS Homo sapiens
206 UBAP1 51271
Proximity Label-MS Homo sapiens
207 CENPE 1062
Proximity Label-MS Homo sapiens
208 ALMS1  
Proximity Label-MS Homo sapiens
209 TPD52L2 7165
Proximity Label-MS Homo sapiens
210 WASF2 10163
Proximity Label-MS Homo sapiens
211 TANC1 85461
Proximity Label-MS