Gene description for MAPK3
Gene name	mitogen-activated protein kinase 3
Gene symbol	MAPK3
Other names/aliases	ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK
Species	Homo sapiens
Database cross references - MAPK3
ExoCarta	ExoCarta_5595
Entrez Gene	5595
HGNC	6877
MIM	601795
UniProt	P27361
MAPK3 identified in exosomes derived from the following tissue/cell type
Keratinocytes	19530224
Keratinocytes	19530224
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for MAPK3

Molecular Function     ATP binding GO:0005524 IEA     phosphatase binding GO:0019902 IPI     protein binding GO:0005515 IPI     phosphotyrosine binding GO:0001784 IEA     MAP kinase activity GO:0004707 TAS Biological Process     toll-like receptor 3 signaling pathway GO:0034138 TAS     insulin receptor signaling pathway GO:0008286 TAS     phosphorylation GO:0016310 IDA     toll-like receptor 9 signaling pathway GO:0034162 TAS     stress-activated MAPK cascade GO:0051403 TAS     activation of MAPKK activity GO:0000186 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     response to epidermal growth factor GO:0070849 IDA     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     regulation of stress-activated MAPK cascade GO:0032872 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     activation of MAPK activity GO:0000187 TAS     positive regulation of protein phosphorylation GO:0001934 IMP     Ras protein signal transduction GO:0007265 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     cellular response to mechanical stimulus GO:0071260 IEP     cytokine-mediated signaling pathway GO:0019221 TAS     blood coagulation GO:0007596 TAS     cellular response to heat GO:0034605 TAS     BMP signaling pathway GO:0030509 IMP     negative regulation of apolipoprotein binding GO:2000657 IEA     transcription from RNA polymerase I promoter GO:0006360 TAS     apoptotic process GO:0006915 IEA     viral process GO:0016032 IEA     axon guidance GO:0007411 TAS     regulation of cytoskeleton organization GO:0051493 TAS     positive regulation of histone phosphorylation GO:0033129 IMP     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     caveolin-mediated endocytosis GO:0072584 TAS     transcription initiation from RNA polymerase I promoter GO:0006361 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     lipopolysaccharide-mediated signaling pathway GO:0031663 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS     innate immune response GO:0045087 TAS     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     gene expression GO:0010467 TAS     positive regulation of cyclase activity GO:0031281 IMP     positive regulation of histone acetylation GO:0035066 IMP     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     DNA damage induced protein phosphorylation GO:0006975 IDA     regulation of Golgi inheritance GO:0090170 TAS     platelet activation GO:0030168 TAS     sensory perception of pain GO:0019233 IEA     cartilage development GO:0051216 IEA     small GTPase mediated signal transduction GO:0007264 TAS     interleukin-1-mediated signaling pathway GO:0070498 IMP     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     MAPK cascade GO:0000165 TAS     regulation of cellular response to heat GO:1900034 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     cell cycle GO:0007049 IEA     regulation of early endosome to late endosome transport GO:2000641 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     peptidyl-tyrosine autophosphorylation GO:0038083 IDA     toll-like receptor 10 signaling pathway GO:0034166 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     response to exogenous dsRNA GO:0043330 IEA     toll-like receptor signaling pathway GO:0002224 TAS     organ morphogenesis GO:0009887 IEA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     protein phosphorylation GO:0006468 IDA Subcellular Localization     extracellular exosome GO:0070062 IDA     nucleus GO:0005634 TAS     cytoskeleton GO:0005856 TAS     late endosome GO:0005770 TAS     caveola GO:0005901 TAS     focal adhesion GO:0005925 TAS     nucleoplasm GO:0005654 TAS     pseudopodium GO:0031143 IEA     early endosome GO:0005769 TAS     Golgi apparatus GO:0005794 TAS     mitochondrion GO:0005739 TAS     nuclear envelope GO:0005635 IDA     cytosol GO:0005829 TAS     microtubule cytoskeleton GO:0015630 IDA