Gene description for Cnp
Gene name 2',3'-cyclic nucleotide 3' phosphodiesterase
Gene symbol Cnp
Other names/aliases CNPase
Cnp-1
Cnp1
Species Mus musculus
 Database cross references - Cnp
ExoCarta ExoCarta_12799
Entrez Gene 12799
UniProt P16330  
 Cnp identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Cnp
Molecular Function
    2',3'-cyclic-nucleotide 3'-phosphodiesterase activity GO:0004113 ISO
    cyclic nucleotide binding GO:0030551 ISO
    hydrolase activity GO:0016787 IEA
    RNA binding GO:0003723 IEA
Biological Process
    oligodendrocyte differentiation GO:0048709 IMP
    regulation of mitochondrial membrane permeability GO:0046902 ISO
    microtubule cytoskeleton organization GO:0000226 ISO
    axonogenesis GO:0007409 IMP
    cyclic nucleotide catabolic process GO:0009214 IEA
    response to toxic substance GO:0009636 IDA
    adult locomotory behavior GO:0008344 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial outer membrane GO:0005741 ISO
    myelin sheath adaxonal region GO:0035749 ISO
    membrane GO:0016020 ISO
    myelin sheath GO:0043209 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    nucleoplasm GO:0005654 ISO
    pseudopodium GO:0031143 ISO
    cytoplasm GO:0005737 ISO
    myelin sheath abaxonal region GO:0035748 ISO
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
    cell projection GO:0042995 ISO
    plasma membrane GO:0005886 ISO
    microvillus GO:0005902 ISO
    microtubule GO:0005874 ISO
 Experiment description of studies that identified Cnp in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Cnp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cnp is involved
No pathways found





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