Gene description for TIA1
Gene name TIA1 cytotoxic granule-associated RNA binding protein
Gene symbol TIA1
Other names/aliases TIA-1
WDM
Species Homo sapiens
 Database cross references - TIA1
ExoCarta ExoCarta_7072
Vesiclepedia VP_7072
Entrez Gene 7072
HGNC 11802
MIM 603518
UniProt P31483  
 TIA1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TIA1
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    mRNA 3'-UTR binding GO:0003730 ISS
    protein binding GO:0005515 IPI
    poly(A) binding GO:0008143 TAS
    mRNA 3'-UTR AU-rich region binding GO:0035925 IEA
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IDA
    negative regulation of cytokine production GO:0001818 IEA
    mRNA processing GO:0006397 IEA
    apoptotic process GO:0006915 IEA
    RNA splicing GO:0008380 IEA
    negative regulation of translation GO:0017148 ISS
    stress granule assembly GO:0034063 IDA
    regulation of mRNA splicing, via spliceosome GO:0048024 IDA
    protein localization to cytoplasmic stress granule GO:1903608 IMP
    positive regulation of epithelial cell apoptotic process GO:1904037 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytoplasmic stress granule GO:0010494 IDA
    cytoplasmic stress granule GO:0010494 ISS
    nuclear stress granule GO:0097165 IDA
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified TIA1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TIA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCBP2 5094
Co-fractionation Homo sapiens
2 VCAM1 7412
Affinity Capture-MS Homo sapiens
3 ELL2 22936
Affinity Capture-MS Homo sapiens
4 Smek1  
Affinity Capture-MS Mus musculus
5 CUL1 8454
Affinity Capture-MS Homo sapiens
6 WDR6 11180
Co-localization Homo sapiens
7 FMNL1 752
Affinity Capture-MS Homo sapiens
8 STT3A 3703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 RPN2 6185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 HTRA2 27429
Co-fractionation Homo sapiens
11 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TRIM31  
Affinity Capture-MS Homo sapiens
13 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MPI 4351
Co-fractionation Homo sapiens
15 RLIM 51132
Affinity Capture-MS Homo sapiens
16 FASTK  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
17 CUL5 8065
Affinity Capture-MS Homo sapiens
18 CUL3 8452
Affinity Capture-MS Homo sapiens
19 RICTOR 253260
Affinity Capture-MS Homo sapiens
20 TMEM258  
Affinity Capture-MS Homo sapiens
21 CAND1 55832
Affinity Capture-MS Homo sapiens
22 PIR 8544
Co-fractionation Homo sapiens
23 DDX58 23586
Co-fractionation Homo sapiens
24 SRSF3 6428
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
25 CDK1 983
Co-fractionation Homo sapiens
26 FN1 2335
Affinity Capture-MS Homo sapiens
27 Rc3h1  
Co-localization Mus musculus
28 ESR1  
Affinity Capture-MS Homo sapiens
29 CXXC4 80319
Affinity Capture-MS Homo sapiens
30 DPPA4  
Affinity Capture-MS Homo sapiens
31 ARIH2 10425
Affinity Capture-MS Homo sapiens
32 MAGT1 84061
Affinity Capture-MS Homo sapiens
33 LUC7L2 51631
Co-fractionation Homo sapiens
34 MAPT  
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
35 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
36 SNRPD1 6632
Co-fractionation Homo sapiens
37 MYC  
Affinity Capture-MS Homo sapiens
38 C9orf72  
Affinity Capture-MS Homo sapiens
39 PCBP1 5093
Co-fractionation Homo sapiens
40 NTRK1 4914
Affinity Capture-MS Homo sapiens
41 PITPNB 23760
Co-fractionation Homo sapiens
42 OSTC 58505
Affinity Capture-MS Homo sapiens
43 DAZAP1 26528
Co-fractionation Homo sapiens
44 Cep85  
Affinity Capture-MS Mus musculus
45 COPS5 10987
Affinity Capture-MS Homo sapiens
46 NETO2  
Affinity Capture-MS Homo sapiens
47 DAD1 1603
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 STT3B 201595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RPN1 6184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 BMI1  
Affinity Capture-MS Homo sapiens
51 POU5F1  
Affinity Capture-MS Homo sapiens
52 CUL2 8453
Affinity Capture-MS Homo sapiens
53 OST4  
Affinity Capture-MS Homo sapiens
54 NANOG  
Affinity Capture-MS Homo sapiens
55 DDOST 1650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MYCN  
Affinity Capture-MS Homo sapiens
57 AK1 203
Affinity Capture-MS Homo sapiens
58 MKI67  
Affinity Capture-MS Homo sapiens
59 Smn1 20595
Affinity Capture-MS Mus musculus
60 MLEC 9761
Affinity Capture-MS Homo sapiens
61 CUL4A 8451
Affinity Capture-MS Homo sapiens
62 ITGA4 3676
Affinity Capture-MS Homo sapiens
63 POLK  
Affinity Capture-MS Homo sapiens
64 CCDC47 57003
Affinity Capture-MS Homo sapiens
65 BCOR  
Affinity Capture-MS Homo sapiens
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