Gene description for HIST1H2BJ
Gene name histone cluster 1, H2bj
Gene symbol HIST1H2BJ
Other names/aliases H2B/r
H2BFR
H2BJ
Species Homo sapiens
 Database cross references - HIST1H2BJ
ExoCarta ExoCarta_8970
Vesiclepedia VP_8970
Entrez Gene 8970
HGNC 4761
MIM 615044
UniProt P06899  
 HIST1H2BJ identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
 Gene ontology annotations for HIST1H2BJ
Molecular Function
    lipopolysaccharide binding GO:0001530 IDA
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    innate immune response in mucosa GO:0002227 IDA
    chromatin organization GO:0006325 NAS
    nucleosome assembly GO:0006334 NAS
    negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 IDA
    antibacterial humoral response GO:0019731 IDA
    killing of cells of another organism GO:0031640 IDA
    defense response to Gram-negative bacterium GO:0050829 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    protein localization to CENP-A containing chromatin GO:0061644 NAS
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
Subcellular Localization
    nucleosome GO:0000786 IPI
    nucleosome GO:0000786 NAS
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    CENP-A containing nucleosome GO:0043505 IPI
 Experiment description of studies that identified HIST1H2BJ in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
3
Experiment ID 139
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
4
Experiment ID 140
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
5
Experiment ID 141
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
6
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
7
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
8
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
9
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for HIST1H2BJ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REC8  
Affinity Capture-MS Homo sapiens
2 PDHA1 5160
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 H2AFJ 55766
Cross-Linking-MS (XL-MS) Homo sapiens
5 SMC3 9126
Cross-Linking-MS (XL-MS) Homo sapiens
6 HBB 3043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HIST1H2BE 8344
Affinity Capture-MS Homo sapiens
8 CBX1 10951
Affinity Capture-MS Homo sapiens
9 ZNF514  
Affinity Capture-MS Homo sapiens
10 RIN3  
Affinity Capture-MS Homo sapiens
11 TEX35  
Cross-Linking-MS (XL-MS) Homo sapiens
12 BTF3 689
Affinity Capture-MS Homo sapiens
13 HIST1H2BG 8339
Affinity Capture-MS Homo sapiens
14 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
15 KIF20A 10112
Affinity Capture-MS Homo sapiens
16 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
17 SFMBT2  
Cross-Linking-MS (XL-MS) Homo sapiens
18 DNAJB3 414061
Cross-Linking-MS (XL-MS) Homo sapiens
19 USP36  
Affinity Capture-MS Homo sapiens
20 TOP2A 7153
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
21 C8orf59  
Cross-Linking-MS (XL-MS) Homo sapiens
22 KIF23 9493
Affinity Capture-MS Homo sapiens
23 MCM2 4171
Affinity Capture-MS Homo sapiens
24 H1FX 8971
Cross-Linking-MS (XL-MS) Homo sapiens
25 PPIE 10450
Affinity Capture-MS Homo sapiens
26 H2AFV 94239
Cross-Linking-MS (XL-MS) Homo sapiens
27 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
28 PRC1 9055
Affinity Capture-MS Homo sapiens
29 FAM47B  
Cross-Linking-MS (XL-MS) Homo sapiens
30 H2AFY2 55506
Affinity Capture-MS Homo sapiens
31 HMGA1 3159
Cross-Linking-MS (XL-MS) Homo sapiens
32 HIST2H2AC 8338
Cross-Linking-MS (XL-MS) Homo sapiens
33 VCAM1 7412
Affinity Capture-MS Homo sapiens
34 NAP1L4 4676
Affinity Capture-MS Homo sapiens
35 H2AFB2  
Affinity Capture-MS Homo sapiens
36 SGOL2 151246
Affinity Capture-MS Homo sapiens
37 KIF14 9928
Affinity Capture-MS Homo sapiens
38 H2AFZ 3015
Cross-Linking-MS (XL-MS) Homo sapiens
39 JMJD6 23210
Two-hybrid Homo sapiens
40 DPPA2  
Cross-Linking-MS (XL-MS) Homo sapiens
41 HIST2H2AB 317772
Cross-Linking-MS (XL-MS) Homo sapiens
42 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
43 TOP3B 8940
Affinity Capture-MS Homo sapiens
44 TLX3  
Two-hybrid Homo sapiens
45 UBB 7314
Cross-Linking-MS (XL-MS) Homo sapiens
46 FGA 2243
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
48 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
49 PSMD14 10213
Affinity Capture-MS Homo sapiens
50 HIST1H2AJ 8331
Cross-Linking-MS (XL-MS) Homo sapiens
51 CBX3 11335
Cross-Linking-MS (XL-MS) Homo sapiens
52 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
53 ACACA 31
Affinity Capture-MS Homo sapiens
54 CFDP1  
Affinity Capture-MS Homo sapiens
55 SLC25A6 293
Cross-Linking-MS (XL-MS) Homo sapiens
56 CHMP4B 128866
Affinity Capture-MS Homo sapiens
57 FGG 2266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 HMGN1  
Cross-Linking-MS (XL-MS) Homo sapiens
59 CKAP5 9793
Cross-Linking-MS (XL-MS) Homo sapiens
60 FAM24B  
Affinity Capture-MS Homo sapiens
61 PCLO 27445
Cross-Linking-MS (XL-MS) Homo sapiens
62 SPANXN2  
Two-hybrid Homo sapiens
63 AHCTF1 25909
Cross-Linking-MS (XL-MS) Homo sapiens
64 CYLC1 1538
Cross-Linking-MS (XL-MS) Homo sapiens
65 ZNF474  
Cross-Linking-MS (XL-MS) Homo sapiens
66 PPM1G 5496
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 DAXX  
Affinity Capture-MS Homo sapiens
68 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
69 HIST1H2AI 8329
Cross-Linking-MS (XL-MS) Homo sapiens
70 HMGN3  
Cross-Linking-MS (XL-MS) Homo sapiens
71 ANLN 54443
Affinity Capture-MS Homo sapiens
72 HIST1H2AA 221613
Cross-Linking-MS (XL-MS) Homo sapiens
73 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
74 HIST1H2AD 3013
Cross-Linking-MS (XL-MS) Homo sapiens
75 TMPO 7112
Affinity Capture-MS Homo sapiens
76 PER2  
Proximity Label-MS Homo sapiens
77 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
78 FANCD2  
Affinity Capture-MS Homo sapiens
79 CDK5R2 8941
Cross-Linking-MS (XL-MS) Homo sapiens
80 ECT2 1894
Affinity Capture-MS Homo sapiens
81 SIRT7  
Affinity Capture-MS Homo sapiens
82 RLIM 51132
Affinity Capture-MS Homo sapiens
83 TNN 63923
Cross-Linking-MS (XL-MS) Homo sapiens
84 ADNP 23394
Affinity Capture-MS Homo sapiens
85 POLR2A 5430
Cross-Linking-MS (XL-MS) Homo sapiens
86 FN1 2335
Affinity Capture-MS Homo sapiens
87 TOMM70A 9868
Cross-Linking-MS (XL-MS) Homo sapiens
88 PDCD4 27250
Cross-Linking-MS (XL-MS) Homo sapiens
89 STAT1 6772
Affinity Capture-Western Homo sapiens
90 HIST1H2AH 85235
Cross-Linking-MS (XL-MS) Homo sapiens
91 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
92 HIST1H3I 8354
Affinity Capture-MS Homo sapiens
93 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
94 DTX3L 151636
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
95 LMNA 4000
Cross-Linking-MS (XL-MS) Homo sapiens
96 APLF  
Affinity Capture-MS Homo sapiens
97 HIST1H2BI 8346
Affinity Capture-MS Homo sapiens
98 SUPT16H 11198
Affinity Capture-MS Homo sapiens
99 MDM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 SPIN2B  
Affinity Capture-MS Homo sapiens
101 H2AFX 3014
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
102 SPTBN1 6711
Cross-Linking-MS (XL-MS) Homo sapiens
103 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
104 C11orf58  
Cross-Linking-MS (XL-MS) Homo sapiens
105 USP48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 PDS5B 23047
Cross-Linking-MS (XL-MS) Homo sapiens
107 HMGN4  
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
108 HIST1H2AC 8334
Cross-Linking-MS (XL-MS) Homo sapiens
109 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
110 H3F3A 3020
Affinity Capture-MS Homo sapiens
111 EIF1AX 1964
Cross-Linking-MS (XL-MS) Homo sapiens
112 MCM5 4174
Affinity Capture-MS Homo sapiens
113 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
114 HBA2 3040
Affinity Capture-MS Homo sapiens
115 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
116 HMGN5 79366
Cross-Linking-MS (XL-MS) Homo sapiens
117 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 PARP9 83666
Affinity Capture-Western Homo sapiens
119 H2AFB3  
Affinity Capture-MS Homo sapiens
120 CREB1  
Affinity Capture-MS Homo sapiens
121 KRR1 11103
Affinity Capture-MS Homo sapiens
122 RNF38  
Affinity Capture-MS Homo sapiens
123 ADAMTS12 81792
Cross-Linking-MS (XL-MS) Homo sapiens
124 HIST2H2AA4 723790
Affinity Capture-MS Homo sapiens
125 DUOX2 50506
Cross-Linking-MS (XL-MS) Homo sapiens
126 PINK1  
Affinity Capture-MS Homo sapiens
127 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
128 HNRNPA1L2 144983
Cross-Linking-MS (XL-MS) Homo sapiens
129 SERBP1 26135
Affinity Capture-MS Homo sapiens
130 PAF1 54623
Affinity Capture-MS Homo sapiens
131 HCLS1 3059
Cross-Linking-MS (XL-MS) Homo sapiens
132 SSRP1 6749
Affinity Capture-MS Homo sapiens
133 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
134 NAP1L5  
Affinity Capture-MS Homo sapiens
135 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which HIST1H2BJ is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
E3 ubiquitin ligases ubiquitinate target proteins TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones TAS Reactome
HATs acetylate histones IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Infectious disease TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification TAS Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Processing of DNA double-strand break ends TAS Reactome
Protein ubiquitination TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Replacement of protamines by nucleosomes in the male pronucleus IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here