Gene description for ATG7
Gene name autophagy related 7
Gene symbol ATG7
Other names/aliases APG7-LIKE
Species Homo sapiens
 Database cross references - ATG7
ExoCarta ExoCarta_10533
Entrez Gene 10533
HGNC 16935
MIM 608760
UniProt O95352  
 ATG7 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ATG7
Molecular Function
    protein binding GO:0005515 IPI
    Atg8 activating enzyme activity GO:0019779 IBA
    ubiquitin activating enzyme activity GO:0004839 IEA
    transcription factor binding GO:0008134 IPI
    protein homodimerization activity GO:0042803 IDA
    Atg12 activating enzyme activity GO:0019778 ISS
Biological Process
    cerebral cortex development GO:0021987 IEA
    macroautophagy GO:0016236 IBA
    positive regulation of mucus secretion GO:0070257 IEA
    positive regulation of protein modification process GO:0031401 IDA
    cellular response to nitrogen starvation GO:0006995 IBA
    negative regulation of histone H4-K16 acetylation GO:2000619 IEA
    central nervous system neuron axonogenesis GO:0021955 IEA
    protein lipidation GO:0006497 IDA
    membrane fusion GO:0061025 TAS
    cerebellar Purkinje cell layer development GO:0021680 IEA
    negative stranded viral RNA replication GO:0039689 IEA
    protein modification by small protein conjugation GO:0032446 IBA
    defense response to virus GO:0051607 IMP
    post-embryonic development GO:0009791 IEA
    cellular amino acid metabolic process GO:0006520 IEA
    cellular response to hyperoxia GO:0071455 IDA
    cellular protein modification process GO:0006464 TAS
    regulation of protein ubiquitination GO:0031396 IEA
    pyramidal neuron development GO:0021860 IEA
    positive regulation of macroautophagy GO:0016239 IMP
    positive regulation of apoptotic process GO:0043065 IMP
    protein transport GO:0015031 IEA
    piecemeal microautophagy of nucleus GO:0034727 IBA
    cellular response to starvation GO:0009267 IDA
    adult walking behavior GO:0007628 IEA
    liver development GO:0001889 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    protein ubiquitination GO:0016567 IEA
    regulation of mitochondrion degradation GO:1903146 IGI
    mitochondrion degradation GO:0000422 IBA
    protein catabolic process GO:0030163 IBA
    cardiac muscle cell development GO:0055013 IEA
    positive regulation of autophagy GO:0010508 IMP
    late nucleophagy GO:0044805 IBA
    suppression by virus of host autophagy GO:0039521 IMP
    neurological system process GO:0050877 IEA
    positive regulation of protein catabolic process GO:0045732 IMP
    C-terminal protein lipidation GO:0006501 IBA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    axoneme GO:0005930 ISS
    pre-autophagosomal structure GO:0000407 IBA
 Experiment description of studies that identified ATG7 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATG7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATG7 is involved
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome

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