Gene description for TTF2
Gene name transcription termination factor, RNA polymerase II
Gene symbol TTF2
Other names/aliases HuF2
ZGRF6
Species Homo sapiens
 Database cross references - TTF2
ExoCarta ExoCarta_8458
Vesiclepedia VP_8458
Entrez Gene 8458
HGNC 12398
MIM 604718
UniProt Q9UNY4  
 TTF2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TTF2
Molecular Function
    DNA binding GO:0003677 IEA
    helicase activity GO:0004386 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP-dependent activity, acting on DNA GO:0008094 IBA
    ATP-dependent activity, acting on DNA GO:0008094 IDA
    zinc ion binding GO:0008270 IEA
    hydrolase activity GO:0016787 IEA
Biological Process
    DNA repair GO:0006281 IBA
    DNA-templated transcription termination GO:0006353 TAS
    termination of RNA polymerase II transcription GO:0006369 TAS
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    spliceosomal complex GO:0005681 IEA
    cytosol GO:0005829 IDA
    transcription elongation factor complex GO:0008023 TAS
 Experiment description of studies that identified TTF2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TTF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAM131B  
Affinity Capture-MS Homo sapiens
2 TNIP1 10318
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 Psmb5 19173
Affinity Capture-MS Mus musculus
4 CIB2  
Affinity Capture-MS Homo sapiens
5 PBK  
Cross-Linking-MS (XL-MS) Homo sapiens
6 HDHD1  
Affinity Capture-MS Homo sapiens
7 UBC 7316
Reconstituted Complex Homo sapiens
8 DNAI2  
Affinity Capture-MS Homo sapiens
9 MRFAP1L1  
Affinity Capture-MS Homo sapiens
10 EMILIN1 11117
Affinity Capture-MS Homo sapiens
11 D2HGDH 728294
Affinity Capture-MS Homo sapiens
12 RFXANK  
Affinity Capture-MS Homo sapiens
13 IMPDH2 3615
Proximity Label-MS Homo sapiens
14 THTPA  
Affinity Capture-MS Homo sapiens
15 CREB1  
Affinity Capture-MS Homo sapiens
16 PPP6R1 22870
Proximity Label-MS Homo sapiens
17 RABL2A 11159
Affinity Capture-MS Homo sapiens
18 HINFP  
Two-hybrid Homo sapiens
19 ATG7 10533
Affinity Capture-MS Homo sapiens
20 PRDX4 10549
Two-hybrid Homo sapiens
21 IL17RA 23765
Affinity Capture-MS Homo sapiens
22 FOXP1 27086
Affinity Capture-MS Homo sapiens
23 NINL  
Proximity Label-MS Homo sapiens
24 POLR2K  
Affinity Capture-MS Homo sapiens
25 PFN1 5216
Proximity Label-MS Homo sapiens
26 SULT1C4  
Affinity Capture-MS Homo sapiens
27 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
28 EMD 2010
Proximity Label-MS Homo sapiens
29 KLHL34  
Affinity Capture-MS Homo sapiens
30 KLK1 3816
Affinity Capture-MS Homo sapiens
31 BRCA2 675
Affinity Capture-MS Homo sapiens
32 HDAC7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 FOXL2  
Affinity Capture-MS Homo sapiens
34 DRAP1 10589
Two-hybrid Homo sapiens
35 PPARD  
Affinity Capture-MS Homo sapiens
36 DCTN1 1639
Proximity Label-MS Homo sapiens
37 SRF  
Affinity Capture-MS Homo sapiens
38 BICD2 23299
Proximity Label-MS Homo sapiens
39 S100B 6285
Affinity Capture-MS Homo sapiens
40 ACTB 60
Proximity Label-MS Homo sapiens
41 CEBPA  
Protein-peptide Homo sapiens
42 UBXN6 80700
Affinity Capture-MS Homo sapiens
43 RPA3 6119
Proximity Label-MS Homo sapiens
44 KDF1  
Affinity Capture-MS Homo sapiens
45 CETN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 DKK3 27122
Affinity Capture-MS Homo sapiens
47 ACAT1 38
Co-fractionation Homo sapiens
48 TUBB 203068
Affinity Capture-MS Homo sapiens
49 PPM1M  
Affinity Capture-MS Homo sapiens
50 XPO1 7514
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 NUBP2 10101
Affinity Capture-MS Homo sapiens
52 BAG2 9532
Affinity Capture-MS Homo sapiens
53 ZSCAN1  
Two-hybrid Homo sapiens
54 TFAP4 7023
Affinity Capture-MS Homo sapiens
55 DCP1A 55802
Two-hybrid Homo sapiens
56 EGFR 1956
Negative Genetic Homo sapiens
57 FKBP8 23770
Proximity Label-MS Homo sapiens
58 TOP3A  
Co-fractionation Homo sapiens
59 IQCF1  
Affinity Capture-MS Homo sapiens
60 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
61 SMAD1 4086
Two-hybrid Homo sapiens
62 MAPRE3  
Proximity Label-MS Homo sapiens
63 FKBP5 2289
Affinity Capture-MS Homo sapiens
64 NRBP1 29959
Affinity Capture-MS Homo sapiens
65 MYBL2 4605
Two-hybrid Homo sapiens
66 C12orf74  
Affinity Capture-MS Homo sapiens
67 RAB2B 84932
Affinity Capture-MS Homo sapiens
68 NIN 51199
Proximity Label-MS Homo sapiens
69 AMZ1  
Affinity Capture-MS Homo sapiens
70 GOLGA1  
Proximity Label-MS Homo sapiens
71 METTL21B  
Affinity Capture-MS Homo sapiens
72 CLPB 81570
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
73 CBWD1 55871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SIRT3  
Affinity Capture-MS Homo sapiens
75 PYHIN1  
Affinity Capture-MS Homo sapiens
76 COMMD1 150684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 TACC3  
Two-hybrid Homo sapiens
78 PDCD6IP 10015
Cross-Linking-MS (XL-MS) Homo sapiens
Two-hybrid Homo sapiens
79 MAP2K2 5605
Affinity Capture-MS Homo sapiens
80 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
81 PRKY  
Affinity Capture-MS Homo sapiens
82 SKIL  
Two-hybrid Homo sapiens
83 SMAD7  
Two-hybrid Homo sapiens
84 CDKL3  
Two-hybrid Homo sapiens
85 GMEB2  
Two-hybrid Homo sapiens
86 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 DNAJA2 10294
Affinity Capture-MS Homo sapiens
88 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 ASB13  
Affinity Capture-MS Homo sapiens
90 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
91 CRYBB3  
Affinity Capture-MS Homo sapiens
92 FOXN1  
Affinity Capture-MS Homo sapiens
93 MAGEA9  
Affinity Capture-MS Homo sapiens
94 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 PPP4R1L  
Affinity Capture-MS Homo sapiens
96 TCF4  
Two-hybrid Homo sapiens
97 SSSCA1 10534
Affinity Capture-MS Homo sapiens
98 OC90  
Affinity Capture-MS Homo sapiens
99 PTGES3 10728
Affinity Capture-MS Homo sapiens
100 C9orf72  
Affinity Capture-MS Homo sapiens
101 PSMC4 5704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 CCT8L2  
Affinity Capture-MS Homo sapiens
103 FKBP9P1 360132
Affinity Capture-MS Homo sapiens
104 NVL  
Two-hybrid Homo sapiens
105 SOHLH1  
Affinity Capture-MS Homo sapiens
106 CDC5L 988
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which TTF2 is involved
No pathways found





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