Gene description for DNMBP
Gene name dynamin binding protein
Gene symbol DNMBP
Other names/aliases ARHGEF36
TUBA
Species Homo sapiens
 Database cross references - DNMBP
ExoCarta ExoCarta_23268
Vesiclepedia VP_23268
Entrez Gene 23268
HGNC 30373
MIM 611282
UniProt Q6XZF7  
 DNMBP identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DNMBP
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of cell shape GO:0008360 IMP
    intracellular signal transduction GO:0035556 IEA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    cilium assembly GO:0060271 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    Golgi apparatus GO:0005794 ISS
    Golgi stack GO:0005795 IEA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    cell-cell junction GO:0005911 IDA
    synapse GO:0045202 ISS
    presynapse GO:0098793 ISS
 Experiment description of studies that identified DNMBP in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DNMBP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNX9 51429
Affinity Capture-MS Homo sapiens
2 ARHGAP17 55114
Two-hybrid Homo sapiens
3 P4HB 5034
Affinity Capture-MS Homo sapiens
4 GTSE1 51512
Affinity Capture-MS Homo sapiens
5 SURF6  
Affinity Capture-MS Homo sapiens
6 DHFR 1719
Affinity Capture-MS Homo sapiens
7 DNM1 1759
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 CNN1 1264
Reconstituted Complex Homo sapiens
9 HOOK1  
Proximity Label-MS Homo sapiens
10 AMOT  
Proximity Label-MS Homo sapiens
11 WIPF3  
Affinity Capture-MS Homo sapiens
12 Cd2ap 12488
Affinity Capture-MS Mus musculus
13 WIPF2 147179
Affinity Capture-MS Homo sapiens
14 PPIP5K2 23262
Affinity Capture-MS Homo sapiens
15 LSM12 124801
Affinity Capture-MS Homo sapiens
16 BUB1B  
Two-hybrid Homo sapiens
17 ACTA1 58
Affinity Capture-MS Homo sapiens
18 RIN3  
Affinity Capture-MS Homo sapiens
19 FOSL1  
Affinity Capture-MS Homo sapiens
20 PFN1 5216
Proximity Label-MS Homo sapiens
21 NCKAP1 10787
Affinity Capture-MS Homo sapiens
22 KRT8 3856
Proximity Label-MS Homo sapiens
23 RNF43  
Proximity Label-MS Homo sapiens
24 FAM96A  
Affinity Capture-MS Homo sapiens
25 DBN1 1627
Affinity Capture-MS Homo sapiens
26 SULT1C4  
Affinity Capture-MS Homo sapiens
27 FASLG 356
Protein-peptide Homo sapiens
28 SNX33 257364
Affinity Capture-MS Homo sapiens
29 SEPT10 151011
Proximity Label-MS Homo sapiens
30 MAD2L1BP  
Affinity Capture-MS Homo sapiens
31 WASF1 8936
Affinity Capture-MS Homo sapiens
32 CRYBB3  
Affinity Capture-MS Homo sapiens
33 TUBG1 7283
Co-fractionation Homo sapiens
34 METTL21B  
Affinity Capture-MS Homo sapiens
35 CLTB 1212
Proximity Label-MS Homo sapiens
36 EVL 51466
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
37 MKI67  
Affinity Capture-MS Homo sapiens
38 VASP 7408
Reconstituted Complex Homo sapiens
39 TUBA1A 7846
Affinity Capture-MS Homo sapiens
40 MAPRE1 22919
Proximity Label-MS Homo sapiens
41 CDC42 998
FRET Homo sapiens
42 ENAH 55740
Reconstituted Complex Homo sapiens
43 MAPRE3  
Proximity Label-MS Homo sapiens
44 MAP7D1 55700
Affinity Capture-MS Homo sapiens
45 PDZD11 51248
Affinity Capture-MS Homo sapiens
46 C10orf88  
Affinity Capture-MS Homo sapiens
47 C12orf74  
Affinity Capture-MS Homo sapiens
48 RASGRF2  
Affinity Capture-MS Homo sapiens
49 MLLT4 4301
Proximity Label-MS Homo sapiens
50 PARD3 56288
Proximity Label-MS Homo sapiens
51 B4GALT2  
Affinity Capture-MS Homo sapiens
52 PXN 5829
Proximity Label-MS Homo sapiens
53 DNM3 26052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CLTA 1211
Proximity Label-MS Homo sapiens
55 GOLGA1  
Proximity Label-MS Homo sapiens
56 BIN3 55909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
57 PLEKHA7 144100
Affinity Capture-MS Homo sapiens
58 HSPA4 3308
Affinity Capture-MS Homo sapiens
59 PPARD  
Affinity Capture-MS Homo sapiens
60 BICD2 23299
Proximity Label-MS Homo sapiens
61 BICD1 636
Proximity Label-MS Homo sapiens
62 PTPN23 25930
Proximity Label-MS Homo sapiens
63 KHDRBS1 10657
Protein-peptide Homo sapiens
64 ETNK2  
Affinity Capture-MS Homo sapiens
65 RAC1 5879
FRET Homo sapiens
66 DNM2 1785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CYFIP2 26999
Affinity Capture-MS Homo sapiens
68 KRT19 3880
Proximity Label-MS Homo sapiens
69 AGPS 8540
Proximity Label-MS Homo sapiens
70 RPA3 6119
Proximity Label-MS Homo sapiens
71 CAPZB 832
Affinity Capture-MS Homo sapiens
72 XRCC5 7520
Co-fractionation Homo sapiens
73 TULP3 7289
Affinity Capture-MS Homo sapiens
74 UBXN6 80700
Affinity Capture-MS Homo sapiens
75 Nedd1  
Affinity Capture-MS Mus musculus
76 WASL 8976
Affinity Capture-MS Homo sapiens
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