Gene description for SVIL
Gene name supervillin
Gene symbol SVIL
Other names/aliases -
Species Homo sapiens
 Database cross references - SVIL
ExoCarta ExoCarta_6840
Vesiclepedia VP_6840
Entrez Gene 6840
HGNC 11480
MIM 604126
UniProt O95425  
 SVIL identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SVIL
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IBA
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IDA
Biological Process
    skeletal muscle tissue development GO:0007519 IMP
    actin polymerization or depolymerization GO:0008154 IBA
    positive regulation of cytokinesis GO:0032467 ISS
    actin filament severing GO:0051014 IBA
    barbed-end actin filament capping GO:0051016 IBA
Subcellular Localization
    podosome GO:0002102 IEA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    focal adhesion GO:0005925 HDA
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 IDA
    actin cytoskeleton GO:0015629 NAS
    midbody GO:0030496 ISS
    cleavage furrow GO:0032154 ISS
    microtubule minus-end GO:0036449 ISS
    cell projection GO:0042995 IEA
    costamere GO:0043034 IDA
 Experiment description of studies that identified SVIL in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SVIL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 ACTR2 10097
Affinity Capture-MS Homo sapiens
3 LUZP4  
Affinity Capture-MS Homo sapiens
4 Cdk1 12534
Affinity Capture-MS Mus musculus
5 HOOK1  
Proximity Label-MS Homo sapiens
6 PPP1CB 5500
Affinity Capture-MS Homo sapiens
7 SYCP1  
Cross-Linking-MS (XL-MS) Homo sapiens
8 Tpm1 22003
Affinity Capture-MS Mus musculus
9 PAXIP1  
Affinity Capture-MS Homo sapiens
10 CENPE 1062
Affinity Capture-MS Homo sapiens
11 ABRA  
Affinity Capture-MS Homo sapiens
12 BUB1  
Two-hybrid Homo sapiens
13 PKM 5315
Cross-Linking-MS (XL-MS) Homo sapiens
14 DAPK1 1612
Affinity Capture-MS Homo sapiens
15 KLC3  
Affinity Capture-MS Homo sapiens
16 Calml3  
Affinity Capture-MS Mus musculus
17 DBN1 1627
Affinity Capture-MS Homo sapiens
18 FBXO45 200933
Affinity Capture-MS Homo sapiens
19 KIF20A 10112
Affinity Capture-MS Homo sapiens
20 ODF2 4957
Two-hybrid Homo sapiens
21 HSP90AB1 3326
Co-fractionation Homo sapiens
22 MYO5C 55930
Affinity Capture-MS Homo sapiens
23 SCAF4 57466
Co-fractionation Homo sapiens
24 Actb 11461
Affinity Capture-MS Mus musculus
25 SNRPD2 6633
Cross-Linking-MS (XL-MS) Homo sapiens
26 OXCT1 5019
Co-fractionation Homo sapiens
27 HMMR  
Two-hybrid Homo sapiens
28 PPP1CC 5501
Affinity Capture-MS Homo sapiens
29 SEPT9 10801
Co-fractionation Homo sapiens
30 CAPZB 832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 Eef1a1 13627
Affinity Capture-MS Mus musculus
32 DTX3  
Affinity Capture-MS Homo sapiens
33 DSTN 11034
Affinity Capture-MS Homo sapiens
34 Trim69  
Affinity Capture-MS Mus musculus
35 KIF23 9493
Affinity Capture-MS Homo sapiens
36 CFAP97  
Affinity Capture-MS Homo sapiens
37 TCTEX1D1  
Affinity Capture-MS Homo sapiens
38 CALD1 800
Affinity Capture-MS Homo sapiens
39 IQGAP1 8826
Affinity Capture-MS Homo sapiens
40 CALM3 808
Affinity Capture-MS Homo sapiens
41 ADD1 118
Affinity Capture-MS Homo sapiens
42 PCNXL3 399909
Two-hybrid Homo sapiens
43 Flot2 14252
Affinity Capture-MS Mus musculus
44 FANCD2  
Affinity Capture-MS Homo sapiens
45 Kif3c  
Affinity Capture-MS Mus musculus
46 ATRX 546
Two-hybrid Homo sapiens
47 MYCBP2 23077
Affinity Capture-MS Homo sapiens
48 DNAJC7 7266
Affinity Capture-MS Homo sapiens
49 CD14 929
Affinity Capture-MS Homo sapiens
50 NME2 4831
Two-hybrid Homo sapiens
51 C2CD4B  
Affinity Capture-MS Homo sapiens
52 MTMR10 54893
Affinity Capture-MS Homo sapiens
53 SH3BGRL 6451
Affinity Capture-MS Homo sapiens
54 TMEM132D  
Two-hybrid Homo sapiens
55 USP7 7874
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
56 MYH13 8735
Affinity Capture-MS Homo sapiens
57 OCLM  
Affinity Capture-MS Homo sapiens
58 P2rx7  
Affinity Capture-MS Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
59 KIF14 9928
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
60 HSPA8 3312
Co-fractionation Homo sapiens
61 PAN3 255967
Two-hybrid Homo sapiens
62 CHMP4C 92421
Affinity Capture-MS Homo sapiens
63 NDUFV2 4729
Co-fractionation Homo sapiens
64 MYO18A 399687
Affinity Capture-MS Homo sapiens
65 KIFC3 3801
Two-hybrid Homo sapiens
66 UXT 8409
Two-hybrid Homo sapiens
67 CAPZA1 829
Affinity Capture-MS Homo sapiens
68 MAPRE1 22919
Affinity Capture-MS Homo sapiens
69 TMEM257  
Affinity Capture-MS Homo sapiens
70 ITGB3BP  
Two-hybrid Homo sapiens
71 TBC1D32 221322
Proximity Label-MS Homo sapiens
72 PTP4A3  
Affinity Capture-MS Homo sapiens
73 PPARG 5468
Two-hybrid Homo sapiens
74 CDH1 999
Proximity Label-MS Homo sapiens
75 CHMP4B 128866
Affinity Capture-MS Homo sapiens
76 VCL 7414
Co-fractionation Homo sapiens
77 BTF3 689
Affinity Capture-MS Homo sapiens
78 MYH9 4627
Affinity Capture-MS Homo sapiens
79 ACTN4 81
Co-fractionation Homo sapiens
80 DCAF7 10238
Affinity Capture-MS Homo sapiens
81 WDR47  
Affinity Capture-MS Homo sapiens
82 LUC7L2 51631
Two-hybrid Homo sapiens
83 BICD2 23299
Proximity Label-MS Homo sapiens
84 ACTB 60
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
85 BCL2L1 598
Affinity Capture-MS Homo sapiens
86 MYH11 4629
Affinity Capture-MS Homo sapiens
87 Coro1c 23790
Affinity Capture-MS Mus musculus
88 LMNB2 84823
Two-hybrid Homo sapiens
89 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TPX2  
Affinity Capture-MS Homo sapiens
91 LIMA1 51474
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
92 MIF4GD 57409
Two-hybrid Homo sapiens
93 Myh9 17886
Affinity Capture-MS Mus musculus
94 KMT2A  
Two-hybrid Homo sapiens
95 ASB15 142685
Affinity Capture-MS Homo sapiens
96 JPH3 57338
Affinity Capture-MS Homo sapiens
97 ARRDC4  
Affinity Capture-MS Homo sapiens
98 ECT2 1894
Affinity Capture-MS Homo sapiens
99 CCT6A 908
Cross-Linking-MS (XL-MS) Homo sapiens
100 CTNNB1 1499
Affinity Capture-MS Homo sapiens
101 MEX3A  
Affinity Capture-RNA Homo sapiens
102 ERLEC1 27248
Affinity Capture-MS Homo sapiens
103 NR3C1 2908
Two-hybrid Homo sapiens
104 PDLIM7 9260
Affinity Capture-MS Homo sapiens
105 ETF1 2107
Cross-Linking-MS (XL-MS) Homo sapiens
106 MYO19  
Affinity Capture-MS Homo sapiens
107 MYO1C 4641
Affinity Capture-MS Homo sapiens
108 ASB16 92591
Affinity Capture-MS Homo sapiens
109 CDK2 1017
Affinity Capture-MS Homo sapiens
110 SYNPO 11346
Affinity Capture-MS Homo sapiens
111 FOS 2353
Proximity Label-MS Homo sapiens
112 Flnb 286940
Affinity Capture-MS Mus musculus
113 MYC  
Affinity Capture-MS Homo sapiens
114 NIN 51199
Proximity Label-MS Homo sapiens
115 TMOD3 29766
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 SPAST 6683
Affinity Capture-MS Homo sapiens
117 DPM2 8818
Affinity Capture-MS Homo sapiens
118 STARD9 57519
Two-hybrid Homo sapiens
119 COA7  
Co-fractionation Homo sapiens
120 HAX1  
Two-hybrid Homo sapiens
121 Ppp1cb 19046
Affinity Capture-MS Mus musculus
122 LMNA 4000
Two-hybrid Homo sapiens
123 MALL  
Affinity Capture-MS Homo sapiens
124 CCDC8  
Affinity Capture-MS Homo sapiens
125 MPHOSPH9  
Two-hybrid Homo sapiens
126 TBX3 6926
Affinity Capture-MS Homo sapiens
127 NES 10763
Affinity Capture-MS Homo sapiens
128 KRT18 3875
Two-hybrid Homo sapiens
129 Lima1  
Affinity Capture-MS Mus musculus
130 RNF43  
Proximity Label-MS Homo sapiens
131 LLGL2 3993
Affinity Capture-MS Homo sapiens
132 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
133 Tmod3 50875
Affinity Capture-MS Mus musculus
134 PARP1 142
Proximity Label-MS Homo sapiens
135 WDR77 79084
Affinity Capture-MS Homo sapiens
136 SSH1  
Proximity Label-MS Homo sapiens
137 C6orf201  
Affinity Capture-MS Homo sapiens
138 PCMT1 5110
Co-fractionation Homo sapiens
139 TNFAIP1 7126
Two-hybrid Homo sapiens
140 MKL2  
Two-hybrid Homo sapiens
141 CXCL6  
Affinity Capture-MS Homo sapiens
142 EZR 7430
Proximity Label-MS Homo sapiens
143 Myo1c 17913
Affinity Capture-MS Mus musculus
144 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 ABCF2 10061
Cross-Linking-MS (XL-MS) Homo sapiens
146 CENPF 1063
Two-hybrid Homo sapiens
147 GBA 2629
Affinity Capture-MS Homo sapiens
148 HSP90AA1 3320
Two-hybrid Homo sapiens
149 Myh10 77579
Affinity Capture-MS Mus musculus
150 ESR1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
151 TRIM37  
Proximity Label-MS Homo sapiens
152 Actr1b 226977
Affinity Capture-MS Mus musculus
153 Mapre1 13589
Affinity Capture-MS Mus musculus
154 FLNA 2316
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
155 RDX 5962
Proximity Label-MS Homo sapiens
156 GAGE5  
Affinity Capture-MS Homo sapiens
157 Flot1 14251
Affinity Capture-MS Mus musculus
158 KRAS 3845
Synthetic Growth Defect Homo sapiens
159 AR 367
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
160 RPA2 6118
Proximity Label-MS Homo sapiens
161 Sept9  
Affinity Capture-MS Mus musculus
162 Tpm4  
Affinity Capture-MS Mus musculus
163 UBE2V2 7336
Affinity Capture-MS Homo sapiens
164 Myl12a  
Affinity Capture-MS Mus musculus
165 SH3PXD2A 9644
Two-hybrid Homo sapiens
166 KIF22  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SVIL is involved
No pathways found





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