Gene description for ITSN1
Gene name	intersectin 1 (SH3 domain protein)
Gene symbol	ITSN1
Other names/aliases	ITSN SH3D1A SH3P17
Species	Homo sapiens
Database cross references - ITSN1
ExoCarta	ExoCarta_6453
Entrez Gene	6453
HGNC	6183
MIM	602442
UniProt	Q15811
ITSN1 identified in exosomes derived from the following tissue/cell type
Urine	21595033
Urine	21595033
Urine	21595033

Gene ontology annotations for ITSN1

Molecular Function     calcium ion binding GO:0005509 NAS     proline-rich region binding GO:0070064 IPI     Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA     guanyl-nucleotide exchange factor activity GO:0005085 NAS     kinase activator activity GO:0019209 IEA     protein binding GO:0005515 IPI     protein complex scaffold GO:0032947 IDA Biological Process     regulation of small GTPase mediated signal transduction GO:0051056 TAS     positive regulation of protein kinase B signaling GO:0051897 IEA     axon guidance GO:0007411 TAS     synaptic vesicle endocytosis GO:0048488 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     apoptotic signaling pathway GO:0097190 TAS     negative regulation of neuron apoptotic process GO:0043524 IEA     small GTPase mediated signal transduction GO:0007264 TAS     ephrin receptor signaling pathway GO:0048013 TAS     positive regulation of apoptotic process GO:0043065 TAS     positive regulation of GTPase activity GO:0043547 NAS     positive regulation of phosphorylation GO:0042327 IEA Subcellular Localization     synapse GO:0045202 IEA     cytosol GO:0005829 TAS     coated pit GO:0005905 IDA     cell junction GO:0030054 IEA     endocytic vesicle GO:0030139 IEA     lamellipodium GO:0030027 IEA     neuron projection GO:0043005 IEA     plasma membrane GO:0005886 IDA