Gene description for TANC1
Gene name tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Gene symbol TANC1
Other names/aliases ROLSB
TANC
Species Homo sapiens
 Database cross references - TANC1
ExoCarta ExoCarta_85461
Vesiclepedia VP_85461
Entrez Gene 85461
HGNC 29364
MIM 611397
UniProt Q9C0D5  
 TANC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TANC1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    myoblast fusion GO:0007520 IEA
    visual learning GO:0008542 IEA
    dendritic spine maintenance GO:0097062 IEA
    regulation of postsynapse organization GO:0099175 IBA
Subcellular Localization
    postsynaptic density GO:0014069 IEA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    axon terminus GO:0043679 IEA
    glutamatergic synapse GO:0098978 IBA
 Experiment description of studies that identified TANC1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TANC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PARD3 56288
Proximity Label-MS Homo sapiens
2 RNF43  
Proximity Label-MS Homo sapiens
3 PHLPP1  
Proximity Label-MS Homo sapiens
4 RAB35 11021
Proximity Label-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 FBXW11  
Affinity Capture-MS Homo sapiens
7 AGAP3 116988
Affinity Capture-MS Homo sapiens
8 OCLN 100506658
Proximity Label-MS Homo sapiens
9 NINL  
Proximity Label-MS Homo sapiens
10 AGAP1  
Affinity Capture-MS Homo sapiens
11 PFN1 5216
Proximity Label-MS Homo sapiens
12 BAG5 9529
Affinity Capture-MS Homo sapiens
13 Skp1a 21402
Affinity Capture-MS Mus musculus
14 CTNNB1 1499
Proximity Label-MS Homo sapiens
15 EZR 7430
Proximity Label-MS Homo sapiens
16 SSSCA1 10534
Affinity Capture-MS Homo sapiens
17 LCK 3932
Proximity Label-MS Homo sapiens
18 GJA1 2697
Proximity Label-MS Homo sapiens
19 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
20 BRD2  
Affinity Capture-MS Homo sapiens
21 FKBP8 23770
Proximity Label-MS Homo sapiens
22 C11orf52 91894
Proximity Label-MS Homo sapiens
23 LYN 4067
Proximity Label-MS Homo sapiens
24 MAPRE1 22919
Proximity Label-MS Homo sapiens
25 NXF1 10482
Affinity Capture-RNA Homo sapiens
26 TRIM24  
Affinity Capture-MS Homo sapiens
27 TRIM52  
Affinity Capture-MS Homo sapiens
28 MAPRE3  
Proximity Label-MS Homo sapiens
29 DNAJC5 80331
Proximity Label-MS Homo sapiens
30 TAX1BP3 30851
Affinity Capture-MS Homo sapiens
31 CDH1 999
Proximity Label-MS Homo sapiens
32 PTPRK 5796
Proximity Label-MS Homo sapiens
33 NIN 51199
Proximity Label-MS Homo sapiens
34 DYRK1A 1859
Affinity Capture-MS Homo sapiens
35 NTRK1 4914
Affinity Capture-MS Homo sapiens
36 ZMYND8 23613
Affinity Capture-MS Homo sapiens
37 GOLGA1  
Proximity Label-MS Homo sapiens
38 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
39 MOV10 4343
Affinity Capture-RNA Homo sapiens
40 BICD2 23299
Proximity Label-MS Homo sapiens
41 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
42 PTGES3 10728
Affinity Capture-MS Homo sapiens
43 SNX27 81609
Affinity Capture-MS Homo sapiens
44 KRAS 3845
Proximity Label-MS Homo sapiens
45 PCM1 5108
Proximity Label-MS Homo sapiens
46 RPA3 6119
Proximity Label-MS Homo sapiens
47 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
48 FLOT1 10211
Proximity Label-MS Homo sapiens
49 C12orf57 113246
Affinity Capture-MS Homo sapiens
50 RMDN3 55177
Proximity Label-MS Homo sapiens
51 DYNC1LI2 1783
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TANC1 is involved
No pathways found





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