Gene description for BICD1
Gene name bicaudal D homolog 1 (Drosophila)
Gene symbol BICD1
Other names/aliases BICD
Species Homo sapiens
 Database cross references - BICD1
ExoCarta ExoCarta_636
Vesiclepedia VP_636
Entrez Gene 636
HGNC 1049
MIM 602204
UniProt Q96G01  
 BICD1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for BICD1
Molecular Function
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
    cytoskeletal anchor activity GO:0008093 IBA
    cytoskeletal anchor activity GO:0008093 IDA
    protein kinase binding GO:0019901 IPI
    small GTPase binding GO:0031267 IPI
    proteinase activated receptor binding GO:0031871 ISS
    dynactin binding GO:0034452 IBA
    dynactin binding GO:0034452 IDA
    dynactin binding GO:0034452 IPI
    dynein intermediate chain binding GO:0045505 IBA
    dynein intermediate chain binding GO:0045505 IDA
    dynein complex binding GO:0070840 IBA
    dynein complex binding GO:0070840 IDA
Biological Process
    RNA processing GO:0006396 TAS
    intracellular mRNA localization GO:0008298 NAS
    anatomical structure morphogenesis GO:0009653 TAS
    viral process GO:0016032 IMP
    protein localization to organelle GO:0033365 IBA
    protein localization to organelle GO:0033365 IDA
    stress granule assembly GO:0034063 ISS
    positive regulation of receptor-mediated endocytosis GO:0048260 IBA
    positive regulation of receptor-mediated endocytosis GO:0048260 IMP
    regulation of microtubule cytoskeleton organization GO:0070507 IBA
    regulation of microtubule cytoskeleton organization GO:0070507 IGI
    minus-end-directed organelle transport along microtubule GO:0072385 IMP
    microtubule anchoring at microtubule organizing center GO:0072393 IBA
    microtubule anchoring at microtubule organizing center GO:0072393 ISS
    negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900737 ISS
    positive regulation of protein localization to centrosome GO:1904781 IGI
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IDA
    centrosome GO:0005813 IMP
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 NAS
    cytoplasmic microtubule GO:0005881 IDA
    membrane GO:0016020 IDA
    cytoplasmic vesicle GO:0031410 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 IMP
    secretory vesicle GO:0099503 IDA
 Experiment description of studies that identified BICD1 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for BICD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Proximity Label-MS Homo sapiens
2 SUFU 51684
Proximity Label-MS Homo sapiens
3 MIB1 57534
Proximity Label-MS Homo sapiens
4 TUBA8 51807
Proximity Label-MS Homo sapiens
5 RASSF8 11228
Proximity Label-MS Homo sapiens
6 CLIP1 6249
Proximity Label-MS Homo sapiens
7 CENPE 1062
Proximity Label-MS Homo sapiens
8 WASF2 10163
Proximity Label-MS Homo sapiens
9 DYNC1I2 1781
Proximity Label-MS Homo sapiens
10 LOC101930123  
Proximity Label-MS Homo sapiens
11 ARFGAP3 26286
Proximity Label-MS Homo sapiens
12 PPP2R3A  
Proximity Label-MS Homo sapiens
13 ITSN2 50618
Proximity Label-MS Homo sapiens
14 DYNC1I1  
Proximity Label-MS Homo sapiens
15 SHB 6461
Proximity Label-MS Homo sapiens
16 PXN 5829
Proximity Label-MS Homo sapiens
17 IFT27 11020
Proximity Label-MS Homo sapiens
18 KIF7 374654
Proximity Label-MS Homo sapiens
19 ST7  
Proximity Label-MS Homo sapiens
20 RAPH1 65059
Proximity Label-MS Homo sapiens
21 BRWD1  
Proximity Label-MS Homo sapiens
22 EPS8 2059
Proximity Label-MS Homo sapiens
23 GSK3A 2931
Proximity Label-MS Homo sapiens
24 CKB 1152
Proximity Label-MS Homo sapiens
25 CAPZB 832
Proximity Label-MS Homo sapiens
26 SCLT1 132320
Proximity Label-MS Homo sapiens
27 INA 9118
Proximity Label-MS Homo sapiens
28 CORO1B 57175
Proximity Label-MS Homo sapiens
29 KIAA1462 57608
Proximity Label-MS Homo sapiens
30 TBC1D31  
Proximity Label-MS Homo sapiens
31 GPATCH1  
Proximity Label-MS Homo sapiens
32 HSPA2 3306
Proximity Label-MS Homo sapiens
33 CFAP97  
Proximity Label-MS Homo sapiens
34 DCTN4 51164
Proximity Label-MS Homo sapiens
35 WDR83  
Proximity Label-MS Homo sapiens
36 CALD1 800
Proximity Label-MS Homo sapiens
37 LASP1 3927
Proximity Label-MS Homo sapiens
38 HGS 9146
Proximity Label-MS Homo sapiens
39 ERC1 23085
Proximity Label-MS Homo sapiens
40 TNIK 23043
Proximity Label-MS Homo sapiens
41 STAT3 6774
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
42 PLEKHG1  
Proximity Label-MS Homo sapiens
43 MAPK14 1432
Two-hybrid Homo sapiens
44 KRI1  
Proximity Label-MS Homo sapiens
45 NFATC3 4775
Proximity Label-MS Homo sapiens
46 IFT81 28981
Proximity Label-MS Homo sapiens
47 GGA1 26088
Proximity Label-MS Homo sapiens
48 IPO8 10526
Proximity Label-MS Homo sapiens
49 HERC2 8924
Proximity Label-MS Homo sapiens
50 PTPN14 5784
Proximity Label-MS Homo sapiens
51 CAPZA1 829
Proximity Label-MS Homo sapiens
52 PRDX4 10549
Proximity Label-MS Homo sapiens
53 SCHIP1  
Affinity Capture-MS Homo sapiens
54 AAK1 22848
Proximity Label-MS Homo sapiens
55 NBN 4683
Proximity Label-MS Homo sapiens
56 LOH12CR1 118426
Proximity Label-MS Homo sapiens
57 N4BP2  
Proximity Label-MS Homo sapiens
58 USP53 54532
Proximity Label-MS Homo sapiens
59 SNX4 8723
Proximity Label-MS Homo sapiens
60 DVL2 1856
Affinity Capture-MS Homo sapiens
61 STON1-GTF2A1L  
Proximity Label-MS Homo sapiens
62 KIF14 9928
Proximity Label-MS Homo sapiens
63 SORBS1 10580
Proximity Label-MS Homo sapiens
64 UNK  
Proximity Label-MS Homo sapiens
65 HSPA9 3313
Proximity Label-MS Homo sapiens
66 TBKBP1  
Proximity Label-MS Homo sapiens
67 MLXIP  
Proximity Label-MS Homo sapiens
68 ARHGAP12  
Proximity Label-MS Homo sapiens
69 ENSA 2029
Proximity Label-MS Homo sapiens
70 AGO3  
Proximity Label-MS Homo sapiens
71 DBNL 28988
Proximity Label-MS Homo sapiens
72 CEP55 55165
Proximity Label-MS Homo sapiens
73 PRPH 5630
Proximity Label-MS Homo sapiens
74 CEP41  
Proximity Label-MS Homo sapiens
75 PIBF1  
Proximity Label-MS Homo sapiens
76 CCDC88C 440193
Proximity Label-MS Homo sapiens
77 CEP192 55125
Proximity Label-MS Homo sapiens
78 ACACA 31
Proximity Label-MS Homo sapiens
79 BTF3L4 91408
Proximity Label-MS Homo sapiens
80 XRN1 54464
Proximity Label-MS Homo sapiens
81 SH3GL1 6455
Proximity Label-MS Homo sapiens
82 MAPRE1 22919
Affinity Capture-MS Homo sapiens
83 PDLIM3 27295
Proximity Label-MS Homo sapiens
84 CNOT4 4850
Proximity Label-MS Homo sapiens
85 OFD1 8481
Proximity Label-MS Homo sapiens
86 ABI2 10152
Proximity Label-MS Homo sapiens
87 AZI2  
Proximity Label-MS Homo sapiens
88 RPS6KB1 6198
Proximity Label-MS Homo sapiens
89 UBR5 51366
Proximity Label-MS Homo sapiens
90 PCCA 5095
Proximity Label-MS Homo sapiens
91 SIPA1L2  
Proximity Label-MS Homo sapiens
92 NTRK1 4914
Affinity Capture-MS Homo sapiens
93 CRKL 1399
Proximity Label-MS Homo sapiens
94 TAB2  
Proximity Label-MS Homo sapiens
95 PPM1A 5494
Proximity Label-MS Homo sapiens
96 SPATA2  
Proximity Label-MS Homo sapiens
97 PLK1 5347
Affinity Capture-MS Homo sapiens
98 CEP164  
Proximity Label-MS Homo sapiens
99 BICD2 23299
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
100 CSNK1E 1454
Proximity Label-MS Homo sapiens
101 STIL  
Proximity Label-MS Homo sapiens
102 EIF4ENIF1 56478
Proximity Label-MS Homo sapiens
103 DBT 1629
Proximity Label-MS Homo sapiens
104 VCPIP1 80124
Proximity Label-MS Homo sapiens
105 ANKRD26 22852
Proximity Label-MS Homo sapiens
106 CYLD  
Proximity Label-MS Homo sapiens
107 SYBU  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 WASL 8976
Proximity Label-MS Homo sapiens
109 ARFGAP1 55738
Proximity Label-MS Homo sapiens
110 TUBB8 347688
Proximity Label-MS Homo sapiens
111 SSX2IP  
Proximity Label-MS Homo sapiens
112 POLR2B 5431
Proximity Label-MS Homo sapiens
113 NCKAP5L  
Proximity Label-MS Homo sapiens
114 DISC1 27185
Two-hybrid Homo sapiens
115 SPC24 147841
Proximity Label-MS Homo sapiens
116 TTC30A 92104
Proximity Label-MS Homo sapiens
117 RAB6A 5870
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
118 ARHGAP32  
Proximity Label-MS Homo sapiens
119 SMG7  
Proximity Label-MS Homo sapiens
120 PROSER3  
Proximity Label-MS Homo sapiens
121 TTC26 79989
Proximity Label-MS Homo sapiens
122 CLINT1 9685
Proximity Label-MS Homo sapiens
123 SIK3 23387
Proximity Label-MS Homo sapiens
124 CEP135  
Proximity Label-MS Homo sapiens
125 MCCC2 64087
Proximity Label-MS Homo sapiens
126 PAN3 255967
Proximity Label-MS Homo sapiens
127 SHROOM3 57619
Proximity Label-MS Homo sapiens
128 LUZP1 7798
Proximity Label-MS Homo sapiens
129 OCRL 4952
Proximity Label-MS Homo sapiens
130 NCKAP1 10787
Proximity Label-MS Homo sapiens
131 TRIP6 7205
Proximity Label-MS Homo sapiens
132 CTTN 2017
Proximity Label-MS Homo sapiens
133 TJP1 7082
Proximity Label-MS Homo sapiens
134 SNX18 112574
Proximity Label-MS Homo sapiens
135 CIT 11113
Affinity Capture-MS Homo sapiens
136 IFFO1  
Proximity Label-MS Homo sapiens
137 RPL21 6144
Proximity Label-MS Homo sapiens
138 USP54 159195
Proximity Label-MS Homo sapiens
139 NANS 54187
Proximity Label-MS Homo sapiens
140 FHL1 2273
Proximity Label-MS Homo sapiens
141 NADK 65220
Proximity Label-MS Homo sapiens
142 C2CD3  
Proximity Label-MS Homo sapiens
143 CNKSR3 154043
Proximity Label-MS Homo sapiens
144 TNRC6B  
Proximity Label-MS Homo sapiens
145 LRRC16A 55604
Proximity Label-MS Homo sapiens
146 ABL2  
Proximity Label-MS Homo sapiens
147 SNX9 51429
Proximity Label-MS Homo sapiens
148 TNRC6A 27327
Proximity Label-MS Homo sapiens
149 HAUS5 23354
Proximity Label-MS Homo sapiens
150 CCDC138  
Proximity Label-MS Homo sapiens
151 IRAK1  
Proximity Label-MS Homo sapiens
152 IST1 9798
Proximity Label-MS Homo sapiens
153 TAB1 10454
Proximity Label-MS Homo sapiens
154 TJP2 9414
Proximity Label-MS Homo sapiens
155 NEFL 4747
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 IFT46 56912
Proximity Label-MS Homo sapiens
157 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
158 CEP170B  
Proximity Label-MS Homo sapiens
159 RIBC1  
Proximity Label-MS Homo sapiens
160 PPFIBP1 8496
Proximity Label-MS Homo sapiens
161 BICD1 636
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
162 PTPN23 25930
Proximity Label-MS Homo sapiens
163 KIAA1671  
Proximity Label-MS Homo sapiens
164 DOCK4 9732
Proximity Label-MS Homo sapiens
165 PCM1 5108
Proximity Label-MS Homo sapiens
166 CEP120  
Proximity Label-MS Homo sapiens
167 KRT19 3880
Proximity Label-MS Homo sapiens
168 IFT22 64792
Proximity Label-MS Homo sapiens
169 HAUS4  
Proximity Label-MS Homo sapiens
170 SASS6 163786
Proximity Label-MS Homo sapiens
171 SEC24B 10427
Proximity Label-MS Homo sapiens
172 TES 26136
Proximity Label-MS Homo sapiens
173 KIAA0232 9778
Proximity Label-MS Homo sapiens
174 GGA3 23163
Proximity Label-MS Homo sapiens
175 SH3PXD2B 285590
Proximity Label-MS Homo sapiens
176 TANK 10010
Proximity Label-MS Homo sapiens
177 GIGYF2 26058
Proximity Label-MS Homo sapiens
178 GPBP1  
Proximity Label-MS Homo sapiens
179 TMEM57  
Proximity Label-MS Homo sapiens
180 TP53 7157
Proximity Label-MS Homo sapiens
181 TTC28 23331
Proximity Label-MS Homo sapiens
182 AGO1  
Proximity Label-MS Homo sapiens
183 SYNJ1 8867
Proximity Label-MS Homo sapiens
184 PIN1 5300
Proximity Label-MS Homo sapiens
185 SDCCAG3  
Proximity Label-MS Homo sapiens
186 SIPA1L3  
Proximity Label-MS Homo sapiens
187 SH3BP5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 TNRC6C  
Proximity Label-MS Homo sapiens
189 DNMBP 23268
Proximity Label-MS Homo sapiens
190 CGNL1  
Proximity Label-MS Homo sapiens
191 ARFIP2 23647
Proximity Label-MS Homo sapiens
192 TRIM25 7706
Proximity Label-MS Homo sapiens
193 RAD50 10111
Proximity Label-MS Homo sapiens
194 TBK1 29110
Proximity Label-MS Homo sapiens
195 TRIM37  
Proximity Label-MS Homo sapiens
196 PDLIM5 10611
Proximity Label-MS Homo sapiens
197 C20orf27 54976
Proximity Label-MS Homo sapiens
198 NEDD1 121441
Proximity Label-MS Homo sapiens
199 DBI 1622
Proximity Label-MS Homo sapiens
200 CNN3 1266
Proximity Label-MS Homo sapiens
201 RAB7A 7879
Proximity Label-MS Homo sapiens
202 PCCB 5096
Proximity Label-MS Homo sapiens
203 ARHGAP29 9411
Proximity Label-MS Homo sapiens
204 KANK2 25959
Proximity Label-MS Homo sapiens
205 BCCIP 56647
Proximity Label-MS Homo sapiens
206 LIMD1 8994
Proximity Label-MS Homo sapiens
207 TAB3 257397
Proximity Label-MS Homo sapiens
208 ANXA2 302
Proximity Label-MS Homo sapiens
209 FAM188B  
Proximity Label-MS Homo sapiens
210 LCP1 3936
Proximity Label-MS Homo sapiens
211 NIN 51199
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
212 POC5  
Proximity Label-MS Homo sapiens
213 CC2D1A 54862
Proximity Label-MS Homo sapiens
214 IFT74 80173
Proximity Label-MS Homo sapiens
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