Gene description for TNS2
Gene name tensin 2
Gene symbol TNS2
Other names/aliases C1-TEN
C1TEN
TENC1
Species Homo sapiens
 Database cross references - TNS2
ExoCarta ExoCarta_23371
Vesiclepedia VP_23371
Entrez Gene 23371
HGNC 19737
MIM 607717
UniProt Q63HR2  
 TNS2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TNS2
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 IDA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    kinase binding GO:0019900 IPI
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    kidney development GO:0001822 IEA
    chromatin remodeling GO:0006338 IEA
    negative regulation of cell population proliferation GO:0008285 IMP
    response to muscle activity GO:0014850 IEA
    cellular homeostasis GO:0019725 IEA
    collagen metabolic process GO:0032963 IEA
    multicellular organism growth GO:0035264 IEA
    peptidyl-tyrosine dephosphorylation GO:0035335 IDA
    negative regulation of insulin receptor signaling pathway GO:0046627 IBA
    negative regulation of insulin receptor signaling pathway GO:0046627 IDA
    multicellular organismal-level homeostasis GO:0048871 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IEA
    focal adhesion GO:0005925 HDA
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified TNS2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TNS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 KRT76 51350
Two-hybrid Homo sapiens
3 AXL 558
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 LUZP4  
Two-hybrid Homo sapiens
5 KRTAP12-3  
Two-hybrid Homo sapiens
6 UTRN 7402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
7 KRTAP11-1  
Two-hybrid Homo sapiens
8 BCKDK 10295
Affinity Capture-MS Homo sapiens
9 CSK 1445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
10 ZNF134 7693
Two-hybrid Homo sapiens
11 BAHD1  
Two-hybrid Homo sapiens
12 YWHAE 7531
Affinity Capture-MS Homo sapiens
13 REL 5966
Two-hybrid Homo sapiens
14 MGAT5B  
Two-hybrid Homo sapiens
15 BRCA1 672
Two-hybrid Homo sapiens
16 TBC1D16  
Two-hybrid Homo sapiens
17 DTNA  
Affinity Capture-MS Homo sapiens
18 ENKD1  
Two-hybrid Homo sapiens
19 KRTAP13-2  
Two-hybrid Homo sapiens
20 TEKT3 64518
Two-hybrid Homo sapiens
21 HOXB9  
Two-hybrid Homo sapiens
22 ZNF648  
Two-hybrid Homo sapiens
23 PRR22  
Two-hybrid Homo sapiens
24 DNAJC10 54431
Affinity Capture-MS Homo sapiens
25 C11orf87  
Two-hybrid Homo sapiens
26 DYRK1A 1859
Affinity Capture-MS Homo sapiens
27 HDLBP 3069
Affinity Capture-MS Homo sapiens
28 CPSF7 79869
Two-hybrid Homo sapiens
29 YWHAG 7532
Affinity Capture-MS Homo sapiens
30 DMD 1756
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CTSZ 1522
Two-hybrid Homo sapiens
32 CCDC33 80125
Two-hybrid Homo sapiens
33 KPRP 448834
Two-hybrid Homo sapiens
34 CATSPER1  
Two-hybrid Homo sapiens
35 YWHAH 7533
Affinity Capture-MS Homo sapiens
36 ARID5A  
Two-hybrid Homo sapiens
37 PHF1  
Two-hybrid Homo sapiens
38 CUL1 8454
Affinity Capture-MS Homo sapiens
39 ERBB2 2064
Protein-peptide Homo sapiens
40 FGFR1 2260
Two-hybrid Homo sapiens
41 GFI1B  
Two-hybrid Homo sapiens
42 SERTAD2 9792
Two-hybrid Homo sapiens
43 KRTAP4-4  
Two-hybrid Homo sapiens
44 TRIM8  
Two-hybrid Homo sapiens
45 YWHAB 7529
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
46 DDX19B 11269
Affinity Capture-MS Homo sapiens
47 AQP1 358
Two-hybrid Homo sapiens
48 NUBP2 10101
Two-hybrid Homo sapiens
49 KIT 3815
Reconstituted Complex Homo sapiens
50 FASLG 356
Two-hybrid Homo sapiens
51 TEKT5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 ACAD8 27034
Affinity Capture-MS Homo sapiens
53 FBXW12  
Affinity Capture-MS Homo sapiens
54 PGAM5 192111
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
55 ERBB3 2065
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
56 SUPT5H 6829
Affinity Capture-MS Homo sapiens
57 SOCS7  
Two-hybrid Homo sapiens
58 BRE 9577
Affinity Capture-MS Homo sapiens
59 KRTAP13-1  
Two-hybrid Homo sapiens
60 CNNM3 26505
Two-hybrid Homo sapiens
61 SNTA1 6640
Affinity Capture-MS Homo sapiens
62 DTNB 1838
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CRKL 1399
Two-hybrid Homo sapiens
64 ZNF837  
Two-hybrid Homo sapiens
65 KRTAP10-5  
Two-hybrid Homo sapiens
66 POLDIP2 26073
Affinity Capture-MS Homo sapiens
67 BICD2 23299
Affinity Capture-MS Homo sapiens
68 CSNK1E 1454
Two-hybrid Homo sapiens
69 DLC1 10395
Reconstituted Complex Homo sapiens
70 PPM1G 5496
Affinity Capture-MS Homo sapiens
71 SNTB1 6641
Affinity Capture-MS Homo sapiens
72 CTNNAL1 8727
Affinity Capture-MS Homo sapiens
73 KRTAP10-7  
Two-hybrid Homo sapiens
74 NOTCH2NL 388677
Two-hybrid Homo sapiens
75 ANO9  
Affinity Capture-MS Homo sapiens
76 KRTAP1-3  
Two-hybrid Homo sapiens
77 KCTD9  
Two-hybrid Homo sapiens
78 FAM46B  
Two-hybrid Homo sapiens
79 KRTAP10-8  
Two-hybrid Homo sapiens
80 C19orf66  
Two-hybrid Homo sapiens
81 ERBB4 2066
Reconstituted Complex Homo sapiens
82 USP54 159195
Two-hybrid Homo sapiens
83 EGFR 1956
Reconstituted Complex Homo sapiens
84 ZNF250  
Two-hybrid Homo sapiens
85 GADD45GIP1  
Affinity Capture-MS Homo sapiens
86 KRTAP10-3  
Two-hybrid Homo sapiens
87 HOXA1 3198
Two-hybrid Homo sapiens
88 OTX1  
Two-hybrid Homo sapiens
89 CRX  
Two-hybrid Homo sapiens
90 INO80B 83444
Two-hybrid Homo sapiens
91 C1orf94  
Two-hybrid Homo sapiens
92 TNS2 23371
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
93 MET 4233
Reconstituted Complex Homo sapiens
94 SORBS3 10174
Two-hybrid Homo sapiens
95 ZNF587  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
96 DZIP1  
Two-hybrid Homo sapiens
97 ZNF417  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
98 KRTAP6-3  
Two-hybrid Homo sapiens
99 REEP6  
Two-hybrid Homo sapiens
100 FAM103A1  
Two-hybrid Homo sapiens
101 ZNF575  
Two-hybrid Homo sapiens
102 ZCCHC14 23174
Two-hybrid Homo sapiens
103 DZIP3  
Two-hybrid Homo sapiens
104 TRAF7  
Affinity Capture-MS Homo sapiens
105 KIF1A 547
Two-hybrid Homo sapiens
106 ITGA5 3678
Affinity Capture-MS Homo sapiens
107 KLHL15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
108 FAM175B 23172
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 ROCK1 6093
Affinity Capture-MS Homo sapiens
110 PIN1 5300
Two-hybrid Homo sapiens
111 BLZF1  
Two-hybrid Homo sapiens
112 BCKDHA 593
Affinity Capture-MS Homo sapiens
113 NBPF19  
Two-hybrid Homo sapiens
114 TNS1 7145
Affinity Capture-MS Homo sapiens
115 RBAK  
Two-hybrid Homo sapiens
116 FAM228A  
Two-hybrid Homo sapiens
117 PKP1 5317
Two-hybrid Homo sapiens
118 PLSCR3 57048
Two-hybrid Homo sapiens
119 LPXN 9404
Two-hybrid Homo sapiens
120 BABAM1 29086
Affinity Capture-MS Homo sapiens
121 ZNF497  
Two-hybrid Homo sapiens
122 ZIM2  
Two-hybrid Homo sapiens
123 ZNF205 7755
Two-hybrid Homo sapiens
124 KRTAP12-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
125 ITPA 3704
Affinity Capture-MS Homo sapiens
126 MYPOP  
Two-hybrid Homo sapiens
127 EIF5A 1984
Affinity Capture-MS Homo sapiens
128 SNTB2 6645
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
129 PRMT1 3276
Affinity Capture-MS Homo sapiens
130 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TNS2 is involved
No pathways found





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