Gene description for UTP14A
Gene name UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
Gene symbol UTP14A
Other names/aliases NYCO16
SDCCAG16
dJ537K23.3
Species Homo sapiens
 Database cross references - UTP14A
ExoCarta ExoCarta_10813
Vesiclepedia VP_10813
Entrez Gene 10813
HGNC 10665
MIM 300508
UniProt Q9BVJ6  
 UTP14A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for UTP14A
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    rRNA processing GO:0006364 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 IDA
    small-subunit processome GO:0032040 IBA
 Experiment description of studies that identified UTP14A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UTP14A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 NOP14 8602
Affinity Capture-MS Homo sapiens
3 APLP1 333
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 TRDMT1  
Two-hybrid Homo sapiens
5 ZNF24  
Two-hybrid Homo sapiens
6 NOP58 51602
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
7 NIN 51199
Two-hybrid Homo sapiens
8 KIAA0020 9933
Co-fractionation Homo sapiens
9 GADD45G  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
10 RPA2 6118
Two-hybrid Homo sapiens
11 P4HA2 8974
Affinity Capture-MS Homo sapiens
12 EIF2B2 8892
Affinity Capture-MS Homo sapiens
13 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
14 NOP56 10528
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
15 SRSF11 9295
Co-fractionation Homo sapiens
16 BYSL 705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RGS1  
Two-hybrid Homo sapiens
18 CSNK2A1 1457
Biochemical Activity Homo sapiens
19 TRMT6 51605
Co-fractionation Homo sapiens
20 HOOK2  
Two-hybrid Homo sapiens
21 PRPF40A 55660
Co-fractionation Homo sapiens
22 SEPT2 4735
Co-fractionation Homo sapiens
23 APP 351
Reconstituted Complex Homo sapiens
24 DNAJB6 10049
Proximity Label-MS Homo sapiens
25 APEX1 328
Proximity Label-MS Homo sapiens
26 SAFB 6294
Co-fractionation Homo sapiens
27 DIMT1 27292
Affinity Capture-MS Homo sapiens
28 DDX23 9416
Proximity Label-MS Homo sapiens
29 RNF10  
Two-hybrid Homo sapiens
30 S100B 6285
Affinity Capture-MS Homo sapiens
31 CEP70  
Two-hybrid Homo sapiens
32 KIF23 9493
Affinity Capture-MS Homo sapiens
33 NOLC1 9221
Co-fractionation Homo sapiens
34 MPHOSPH10 10199
Co-fractionation Homo sapiens
35 NPM1 4869
Affinity Capture-MS Homo sapiens
36 SRRM2 23524
Co-fractionation Homo sapiens
37 RPS8 6202
Affinity Capture-MS Homo sapiens
38 FBL 2091
Proximity Label-MS Homo sapiens
39 POLR1E  
Proximity Label-MS Homo sapiens
40 SSR1 6745
Two-hybrid Homo sapiens
41 OBSL1 23363
Affinity Capture-MS Homo sapiens
42 TINAGL1 64129
Two-hybrid Homo sapiens
43 RSRC1  
Two-hybrid Homo sapiens
44 SNRNP48  
Two-hybrid Homo sapiens
45 FAM207A  
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
46 EED  
Affinity Capture-MS Homo sapiens
47 DDX18 8886
Co-fractionation Homo sapiens
48 KLHL20  
Affinity Capture-MS Homo sapiens
49 MECP2 4204
Affinity Capture-MS Homo sapiens
50 ARIH2 10425
Two-hybrid Homo sapiens
51 Cask 12361
Two-hybrid Mus musculus
52 BUD31 8896
Co-fractionation Homo sapiens
53 CSNK2B 1460
Two-hybrid Homo sapiens
54 RPS11 6205
Affinity Capture-MS Homo sapiens
55 NCSTN 23385
Co-fractionation Homo sapiens
56 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 KIF14 9928
Affinity Capture-MS Homo sapiens
58 PPP1R16B  
Affinity Capture-MS Homo sapiens
59 PES1 23481
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
60 RHOH  
Two-hybrid Homo sapiens
61 NINL  
Two-hybrid Homo sapiens
62 KLF16  
Proximity Label-MS Homo sapiens
63 CHMP4C 92421
Affinity Capture-MS Homo sapiens
64 PHF10  
Two-hybrid Homo sapiens
65 NOP2 4839
Co-fractionation Homo sapiens
66 TSR1 55720
Affinity Capture-MS Homo sapiens
67 HOOK1  
Two-hybrid Homo sapiens
68 KRT31 3881
Two-hybrid Homo sapiens
69 TP53BP2  
Two-hybrid Homo sapiens
70 SRSF3 6428
Co-fractionation Homo sapiens
71 RPF2 84154
Co-fractionation Homo sapiens
72 MAPRE1 22919
Affinity Capture-MS Homo sapiens
73 ACIN1 22985
Co-fractionation Homo sapiens
74 HTT 3064
Two-hybrid Homo sapiens
75 PNO1 56902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 CBX3 11335
Proximity Label-MS Homo sapiens
77 TRIM37  
Proximity Label-MS Homo sapiens
78 C12orf49  
Negative Genetic Homo sapiens
79 PDCD5 9141
Two-hybrid Homo sapiens
80 DEK 7913
Co-fractionation Homo sapiens
81 NFIA 4774
Co-fractionation Homo sapiens
82 RPL31 6160
Proximity Label-MS Homo sapiens
83 IFI16 3428
Affinity Capture-MS Homo sapiens
84 BICD2 23299
Two-hybrid Homo sapiens
85 SF3B6 51639
Co-fractionation Homo sapiens
86 DHX9 1660
Co-fractionation Homo sapiens
87 HECTD1 25831
Affinity Capture-MS Homo sapiens
88 BRD4 23476
Affinity Capture-MS Homo sapiens
89 RABIF  
Two-hybrid Homo sapiens
90 UTP14C  
Affinity Capture-MS Homo sapiens
91 SAT1  
Two-hybrid Homo sapiens
92 DDX27 55661
Co-fractionation Homo sapiens
93 GTPBP4 23560
Co-fractionation Homo sapiens
94 CD3EAP  
Proximity Label-MS Homo sapiens
95 ANLN 54443
Affinity Capture-MS Homo sapiens
96 FGFBP1 9982
Affinity Capture-MS Homo sapiens
97 DLEU1  
Two-hybrid Homo sapiens
98 SFPQ 6421
Co-fractionation Homo sapiens
99 RBM39 9584
Co-fractionation Homo sapiens
100 FANCD2  
Affinity Capture-MS Homo sapiens
101 XPO1 7514
Affinity Capture-MS Homo sapiens
102 RC3H2  
Affinity Capture-MS Homo sapiens
103 SIRT7  
Affinity Capture-MS Homo sapiens
104 CTNNB1 1499
Affinity Capture-MS Homo sapiens
105 SRSF1 6426
Co-fractionation Homo sapiens
106 TXLNB  
Two-hybrid Homo sapiens
107 WDR33 55339
Two-hybrid Homo sapiens
108 PRKCZ 5590
Two-hybrid Homo sapiens
109 ERLEC1 27248
Affinity Capture-MS Homo sapiens
110 PTEN 5728
Two-hybrid Homo sapiens
111 DCAF13 25879
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
112 SRSF5 6430
Co-fractionation Homo sapiens
113 DHX37  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 LAMTOR5 10542
Two-hybrid Homo sapiens
115 SF3A1 10291
Co-fractionation Homo sapiens
116 AKTIP  
Two-hybrid Homo sapiens
117 RBM4B  
Affinity Capture-MS Homo sapiens
118 DKC1 1736
Co-fractionation Homo sapiens
119 PRPF19 27339
Co-fractionation Homo sapiens
120 MYC  
Affinity Capture-MS Homo sapiens
121 RPA3 6119
Proximity Label-MS Homo sapiens
122 LSM3 27258
Two-hybrid Homo sapiens
123 DNAJC9 23234
Proximity Label-MS Homo sapiens
124 PDZK1IP1 10158
Two-hybrid Homo sapiens
125 CCDC85B  
Two-hybrid Homo sapiens
126 NHP2L1 4809
Co-fractionation Homo sapiens
127 HP1BP3 50809
Co-fractionation Homo sapiens
128 MYCN  
Affinity Capture-MS Homo sapiens
129 MATR3 9782
Co-fractionation Homo sapiens
130 SRSF10 10772
Co-fractionation Homo sapiens
131 SF3B3 23450
Co-fractionation Homo sapiens
132 FOXQ1  
Affinity Capture-MS Homo sapiens
133 SEPT7 989
Co-fractionation Homo sapiens
134 TFIP11  
Two-hybrid Homo sapiens
135 SMYD1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
136 BRD3 8019
Affinity Capture-MS Homo sapiens
137 FTSJ3 117246
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
138 PHGDH 26227
Co-fractionation Homo sapiens
139 RPS16 6217
Affinity Capture-MS Homo sapiens
140 Sf3a3 75062
Two-hybrid Mus musculus
141 RPL13 6137
Affinity Capture-MS Homo sapiens
142 EXOSC10 5394
Co-fractionation Homo sapiens
143 MAPKAPK2 9261
Affinity Capture-MS Homo sapiens
144 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
145 FBXW11  
Affinity Capture-MS Homo sapiens
146 PARP1 142
Proximity Label-MS Homo sapiens
147 PSG1  
Two-hybrid Homo sapiens
148 FBXL6  
Affinity Capture-MS Homo sapiens
149 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
150 CHCHD1  
Proximity Label-MS Homo sapiens
151 RBM25 58517
Co-fractionation Homo sapiens
152 MNDA 4332
Affinity Capture-MS Homo sapiens
153 USP36  
Affinity Capture-MS Homo sapiens
154 RPAP2  
Affinity Capture-MS Homo sapiens
155 COX8A  
Proximity Label-MS Homo sapiens
156 CCDC106  
Two-hybrid Homo sapiens
157 S100A9 6280
Co-fractionation Homo sapiens
158 AXIN1  
Two-hybrid Homo sapiens
159 MKI67  
Affinity Capture-MS Homo sapiens
160 NIFK 84365
Proximity Label-MS Homo sapiens
161 WDR18 57418
Co-fractionation Homo sapiens
162 VDAC2 7417
Co-fractionation Homo sapiens
163 DHX40  
Proximity Label-MS Homo sapiens
164 MIF 4282
Affinity Capture-MS Homo sapiens
165 NUP50 10762
Proximity Label-MS Homo sapiens
166 TERF1 7013
Two-hybrid Homo sapiens
167 E2F4  
Affinity Capture-MS Homo sapiens
168 RPS24 6229
Proximity Label-MS Homo sapiens
169 PTPRS 5802
Two-hybrid Homo sapiens
170 HNRNPH3 3189
Two-hybrid Homo sapiens
171 HNRNPC 3183
Co-fractionation Homo sapiens
172 RPL7A 6130
Affinity Capture-MS Homo sapiens
173 Fez2  
Two-hybrid Mus musculus
174 RPS6 6194
Proximity Label-MS Homo sapiens
175 LDOC1  
Two-hybrid Homo sapiens
176 XRCC6 2547
Proximity Label-MS Homo sapiens
177 HNRNPU 3192
Co-fractionation Homo sapiens
178 LMO1  
Two-hybrid Homo sapiens
179 VIM 7431
Two-hybrid Homo sapiens
180 DCP2  
Affinity Capture-MS Homo sapiens
181 DDX56  
Co-fractionation Homo sapiens
182 USO1 8615
Two-hybrid Homo sapiens
183 EXOSC8  
Two-hybrid Homo sapiens
184 CDC5L 988
Co-fractionation Homo sapiens
185 CPE 1363
Two-hybrid Homo sapiens
186 PARN  
Affinity Capture-MS Homo sapiens
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