Gene description for ERBB2
Gene name	erb-b2 receptor tyrosine kinase 2
Gene symbol	ERBB2
Other names/aliases	CD340 HER-2 HER-2/neu HER2 MLN 19 NEU NGL TKR1
Species	Homo sapiens
Database cross references - ERBB2
ExoCarta	ExoCarta_2064
Entrez Gene	2064
HGNC	3430
MIM	164870
UniProt	P04626
ERBB2 identified in exosomes derived from the following tissue/cell type
Breast cancer cells	16302729
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Endothelial cells	26027894
Malignant ascites	12147373
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Squamous carcinoma cells	20124223

Gene ontology annotations for ERBB2

Molecular Function     protein C-terminus binding GO:0008022 IPI     ErbB-3 class receptor binding GO:0043125 TAS     protein heterodimerization activity GO:0046982 IPI     receptor signaling protein tyrosine kinase activity GO:0004716 IEA     protein tyrosine kinase activity GO:0004713 TAS     protein binding GO:0005515 IPI     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA     identical protein binding GO:0042802 IPI     transmembrane signaling receptor activity GO:0004888 IDA     protein dimerization activity GO:0046983 NAS     ATP binding GO:0005524 IEA     protein phosphatase binding GO:0019903 IPI     growth factor binding GO:0019838 IDA     RNA polymerase I core binding GO:0001042 IDA Biological Process     positive regulation of protein phosphorylation GO:0001934 ISS     positive regulation of transcription from RNA polymerase III promoter GO:0045945 IDA     heart development GO:0007507 IEA     protein phosphorylation GO:0006468 TAS     positive regulation of cell growth GO:0030307 IMP     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     positive regulation of cell adhesion GO:0045785 IDA     signal transduction GO:0007165 IDA     phosphatidylinositol-mediated signaling GO:0048015 TAS     wound healing GO:0042060 IDA     peptidyl-tyrosine phosphorylation GO:0018108 TAS     positive regulation of epithelial cell proliferation GO:0050679 IDA     protein autophosphorylation GO:0046777 IDA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     regulation of ERK1 and ERK2 cascade GO:0070372 IMP     signal transduction by protein phosphorylation GO:0023014 TAS     neuromuscular junction development GO:0007528 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     enzyme linked receptor protein signaling pathway GO:0007167 TAS     oligodendrocyte differentiation GO:0048709 IEA     axon guidance GO:0007411 TAS     positive regulation of MAP kinase activity GO:0043406 IDA     cell surface receptor signaling pathway GO:0007166 IDA     positive regulation of transcription from RNA polymerase I promoter GO:0045943 IMP     positive regulation of translation GO:0045727 IMP     peripheral nervous system development GO:0007422 IEA     cell proliferation GO:0008283 TAS     motor neuron axon guidance GO:0008045 IEA     myelination GO:0042552 IEA     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS     phosphatidylinositol 3-kinase signaling GO:0014065 IDA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     regulation of microtubule-based process GO:0032886 IDA     negative regulation of immature T cell proliferation in thymus GO:0033088 IEA     regulation of angiogenesis GO:0045765 NAS     transcription, DNA-templated GO:0006351 IEA     innate immune response GO:0045087 TAS     positive regulation of GTPase activity GO:0043547 ISS Subcellular Localization     apical plasma membrane GO:0016324 IEA     basolateral plasma membrane GO:0016323 IDA     endosome membrane GO:0010008 IDA     receptor complex GO:0043235 TAS     nucleus GO:0005634 IDA     cytoplasmic vesicle GO:0031410 IEA     perinuclear region of cytoplasm GO:0048471 IEA     plasma membrane GO:0005886 TAS     integral component of membrane GO:0016021 NAS     cytoplasm GO:0005737 IDA