Gene description for PIK3R2
Gene name phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Gene symbol PIK3R2
Other names/aliases MPPH
MPPH1
P85B
p85
p85-BETA
Species Homo sapiens
 Database cross references - PIK3R2
ExoCarta ExoCarta_5296
Vesiclepedia VP_5296
Entrez Gene 5296
HGNC 8980
MIM 603157
UniProt O00459  
 PIK3R2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PIK3R2
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    protein binding GO:0005515 IPI
    protein phosphatase binding GO:0019903 IPI
    receptor tyrosine kinase binding GO:0030971 IPI
    phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IEA
    1-phosphatidylinositol-3-kinase regulator activity GO:0046935 IBA
    protein heterodimerization activity GO:0046982 ISS
Biological Process
    intracellular glucose homeostasis GO:0001678 ISS
    immune response GO:0006955 NAS
    insulin receptor signaling pathway GO:0008286 IBA
    regulation of autophagy GO:0010506 IMP
    protein transport GO:0015031 IEA
    B cell differentiation GO:0030183 NAS
    T cell differentiation GO:0030217 NAS
    regulation of actin filament polymerization GO:0030833 IEA
    cellular response to insulin stimulus GO:0032869 ISS
    response to endoplasmic reticulum stress GO:0034976 ISS
    positive regulation of protein import into nucleus GO:0042307 ISS
    negative regulation of MAPK cascade GO:0043409 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IDA
    positive regulation of cell adhesion GO:0045785 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    regulation of stress fiber assembly GO:0051492 IEA
    regulation of protein localization to plasma membrane GO:1903076 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    cytosol GO:0005829 TAS
    focal adhesion GO:0005925 IEA
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 IBA
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 IPI
    phosphatidylinositol 3-kinase complex, class IA GO:0005943 NAS
 Experiment description of studies that identified PIK3R2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PIK3R2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AXL 558
Biochemical Activity Homo sapiens
2 KRT4 3851
Affinity Capture-MS Homo sapiens
3 WDR6 11180
Affinity Capture-MS Homo sapiens
4 TPGS1  
Affinity Capture-MS Homo sapiens
5 STAB1  
Two-hybrid Homo sapiens
6 KRT1 3848
Affinity Capture-MS Homo sapiens
7 OCLN 100506658
Proximity Label-MS Homo sapiens
8 SHC1 6464
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 HSPA6 3310
Affinity Capture-MS Homo sapiens
10 MARCKS 4082
Proximity Label-MS Homo sapiens
11 RPL30 6156
Affinity Capture-MS Homo sapiens
12 GJA1 2697
Proximity Label-MS Homo sapiens
13 SQSTM1 8878
Affinity Capture-Western Homo sapiens
14 KRT17 3872
Affinity Capture-MS Homo sapiens
15 YWHAE 7531
Affinity Capture-MS Homo sapiens
16 CRK 1398
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TRIM66  
Affinity Capture-MS Homo sapiens
18 HSPA1L 3305
Affinity Capture-MS Homo sapiens
19 USP9X 8239
Affinity Capture-MS Homo sapiens
20 SEMG2 6407
Affinity Capture-MS Homo sapiens
21 APP 351
Reconstituted Complex Homo sapiens
22 HEPACAM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PIK3CD 5293
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
24 MRFAP1L1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 RINT1 60561
Two-hybrid Homo sapiens
26 D2HGDH 728294
Affinity Capture-MS Homo sapiens
27 CXADR 1525
Proximity Label-MS Homo sapiens
28 IQGAP1 8826
Affinity Capture-MS Homo sapiens
29 RCBTB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SYK 6850
Two-hybrid Homo sapiens
31 SLC31A1 1317
Affinity Capture-MS Homo sapiens
32 CD3E 916
Affinity Capture-Western Homo sapiens
33 GAB2 9846
Affinity Capture-MS Homo sapiens
34 KRT5 3852
Affinity Capture-MS Homo sapiens
35 ITGA4 3676
Affinity Capture-MS Homo sapiens
36 DNAJC7 7266
Proximity Label-MS Homo sapiens
37 VCAM1 7412
Affinity Capture-MS Homo sapiens
38 Mbp 17196
Protein-peptide Mus musculus
39 CD28  
Affinity Capture-Western Homo sapiens
40 RAB35 11021
Proximity Label-MS Homo sapiens
41 CBLB 868
Affinity Capture-Western Homo sapiens
42 ADARB2  
Affinity Capture-MS Homo sapiens
43 ERBB2 2064
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
44 FGFR1 2260
Two-hybrid Homo sapiens
45 EEF1A1 1915
Affinity Capture-MS Homo sapiens
46 LAMTOR1 55004
Proximity Label-MS Homo sapiens
47 HSPA8 3312
Affinity Capture-MS Homo sapiens
48 KCNE3  
Affinity Capture-MS Homo sapiens
49 YWHAB 7529
Affinity Capture-MS Homo sapiens
50 VSIG4  
Affinity Capture-MS Homo sapiens
51 AURKA 6790
Affinity Capture-MS Homo sapiens
52 IRS4 8471
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 KIT 3815
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
55 CX3CL1  
Affinity Capture-MS Homo sapiens
56 USP11 8237
Affinity Capture-MS Homo sapiens
57 CD7  
Affinity Capture-MS Homo sapiens
58 ERBB3 2065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
59 RPS10 6204
Affinity Capture-MS Homo sapiens
60 AVPR1B  
Affinity Capture-MS Homo sapiens
61 LYN 4067
Proximity Label-MS Homo sapiens
62 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
63 GOLGA2 2801
Two-hybrid Homo sapiens
64 TEC 7006
Two-hybrid Homo sapiens
65 SOCS6  
Affinity Capture-MS Homo sapiens
66 ACACA 31
Affinity Capture-MS Homo sapiens
67 DNAJC5 80331
Proximity Label-MS Homo sapiens
68 TUBA1C 84790
Affinity Capture-MS Homo sapiens
69 FYN 2534
Reconstituted Complex Homo sapiens
70 MYH9 4627
Affinity Capture-MS Homo sapiens
71 VCP 7415
Affinity Capture-MS Homo sapiens
72 NTRK1 4914
Affinity Capture-MS Homo sapiens
73 CRKL 1399
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
74 CCR5 1234
Affinity Capture-Western Homo sapiens
75 KRT9 3857
Affinity Capture-MS Homo sapiens
76 ALDH3B1 221
Affinity Capture-MS Homo sapiens
77 MOV10 4343
Affinity Capture-RNA Homo sapiens
78 DYDC1  
Two-hybrid Homo sapiens
79 YWHAQ 10971
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
80 ACTB 60
Affinity Capture-MS Homo sapiens
81 MYH10 4628
Affinity Capture-MS Homo sapiens
82 PIK3R1 5295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 GRB2 2885
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 KRT79 338785
Affinity Capture-MS Homo sapiens
85 UBXN6 80700
Affinity Capture-MS Homo sapiens
86 TRIM23 373
Two-hybrid Homo sapiens
87 TMEM52B 120939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 RPS5 6193
Affinity Capture-MS Homo sapiens
89 PTPN11 5781
Affinity Capture-MS Homo sapiens
90 TUBB 203068
Affinity Capture-MS Homo sapiens
91 NDUFB10 4716
Affinity Capture-MS Homo sapiens
92 YWHAZ 7534
Affinity Capture-MS Homo sapiens
93 IKZF3  
Two-hybrid Homo sapiens
94 LAMP1 3916
Proximity Label-MS Homo sapiens
95 MYH14 79784
Affinity Capture-MS Homo sapiens
96 CUL3 8452
Affinity Capture-MS Homo sapiens
97 PTEN 5728
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
98 ERBB4 2066
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
99 LTBP3 4054
Two-hybrid Homo sapiens
100 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
101 ARF6 382
Proximity Label-MS Homo sapiens
102 FUS 2521
Affinity Capture-MS Homo sapiens
103 CORO1C 23603
Affinity Capture-MS Homo sapiens
104 SPTBN1 6711
Affinity Capture-MS Homo sapiens
105 GAB1  
Reconstituted Complex Homo sapiens
106 NXF1 10482
Affinity Capture-RNA Homo sapiens
107 FLRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 SEMG1 6406
Affinity Capture-MS Homo sapiens
109 KRT15 3866
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
110 PRKACA 5566
Proximity Label-MS Homo sapiens
111 PRMT2  
Affinity Capture-MS Homo sapiens
112 PIK3CA 5290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 MET 4233
Reconstituted Complex Homo sapiens
114 RHOB 388
Proximity Label-MS Homo sapiens
115 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 KRT2 3849
Affinity Capture-MS Homo sapiens
117 KRT16 3868
Affinity Capture-MS Homo sapiens
118 FLOT1 10211
Proximity Label-MS Homo sapiens
119 HAUS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 FASN 2194
Negative Genetic Homo sapiens
121 GRN 2896
Two-hybrid Homo sapiens
122 TGFBR2 7048
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 HAUS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 INPPL1 3636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 TGFBR1 7046
Affinity Capture-Western Homo sapiens
127 DDX3X 1654
Affinity Capture-MS Homo sapiens
128 KRT10 3858
Affinity Capture-MS Homo sapiens
129 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 EDEM1  
Affinity Capture-MS Homo sapiens
131 LCK 3932
Proximity Label-MS Homo sapiens
132 EFNB1 1947
Affinity Capture-MS Homo sapiens
133 ABL1 25
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
134 PIK3CB 5291
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 NISCH 11188
Affinity Capture-MS Homo sapiens
136 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
137 C11orf52 91894
Proximity Label-MS Homo sapiens
138 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 TUBB6 84617
Affinity Capture-MS Homo sapiens
140 ESR1  
Affinity Capture-Western Homo sapiens
141 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 KRT6C 286887
Affinity Capture-MS Homo sapiens
143 RAB2A 5862
Proximity Label-MS Homo sapiens
144 KRT20 54474
Two-hybrid Homo sapiens
145 KRT38 8687
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
146 DNAJC5B  
Proximity Label-MS Homo sapiens
147 ARRB1 408
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
148 RAB7A 7879
Proximity Label-MS Homo sapiens
149 LAMB2 3913
Two-hybrid Homo sapiens
150 RPS7 6201
Affinity Capture-MS Homo sapiens
151 EPHA2 1969
Proximity Label-MS Homo sapiens
152 KRAS 3845
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
153 AR 367
Reconstituted Complex Homo sapiens
154 CAV1 857
Proximity Label-MS Homo sapiens
155 PIK3R3 8503
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 HSPA1B 3304
Affinity Capture-MS Homo sapiens
157 KRT14 3861
Affinity Capture-MS Homo sapiens
158 BCR 613
Affinity Capture-MS Homo sapiens
159 MED28  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PIK3R2 is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Axon guidance TAS Reactome
CD28 co-stimulation TAS Reactome
CD28 dependent PI3K/Akt signaling TAS Reactome
CDC42 GTPase cycle TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Cell-Cell communication IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Costimulation by the CD28 family TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
DAP12 interactions TAS Reactome
DAP12 signaling TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signal transduction TAS Reactome
Downstream TCR signaling TAS Reactome
ESR-mediated signaling TAS Reactome
Extra-nuclear estrogen signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
G alpha (q) signalling events TAS Reactome
GPCR downstream signalling TAS Reactome
GPVI-mediated activation cascade TAS Reactome
Hemostasis TAS Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
IGF1R signaling cascade TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Innate Immune System TAS Reactome
Insulin receptor signalling cascade TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Interleukin-7 signaling IEA Reactome
Interleukin-7 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
IRS-mediated signalling TAS Reactome
IRS-related events triggered by IGF1R TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nephrin family interactions IEA Reactome
Nervous system development TAS Reactome
Phospholipid metabolism TAS Reactome
PI Metabolism TAS Reactome
PI3K Cascade TAS Reactome
PI3K/AKT activation TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
RAC1 GTPase cycle TAS Reactome
RAC2 GTPase cycle TAS Reactome
RAC3 GTPase cycle TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of signaling by CBL TAS Reactome
Regulation of signaling by CBL IEA Reactome
Response of endothelial cells to shear stress IEA Reactome
RET signaling TAS Reactome
RHO GTPase cycle TAS Reactome
RHOA GTPase cycle TAS Reactome
RHOB GTPase cycle TAS Reactome
RHOD GTPase cycle TAS Reactome
RHOF GTPase cycle TAS Reactome
RHOJ GTPase cycle TAS Reactome
RHOU GTPase cycle TAS Reactome
RND1 GTPase cycle TAS Reactome
RND2 GTPase cycle TAS Reactome
RND3 GTPase cycle TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
Role of phospholipids in phagocytosis TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by KIT in disease TAS Reactome
Signaling by LTK TAS Reactome
Signaling by LTK in cancer TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRKs TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by PDGF TAS Reactome
Signaling by PDGFR in disease TAS Reactome
Signaling by PDGFRA extracellular domain mutants TAS Reactome
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) TAS Reactome
Signaling by VEGF IEA Reactome
Signaling by VEGF TAS Reactome
Synthesis of PIPs at the plasma membrane TAS Reactome
TCR signaling TAS Reactome
Tie2 Signaling TAS Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFA-VEGFR2 Pathway TAS Reactome





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