Gene description for IL6ST
Gene name	interleukin 6 signal transducer
Gene symbol	IL6ST
Other names/aliases	CD130 CDW130 GP130 IL-6RB
Species	Homo sapiens
Database cross references - IL6ST
ExoCarta	ExoCarta_3572
Entrez Gene	3572
HGNC	6021
MIM	600694
UniProt	P40189
IL6ST identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for IL6ST

Molecular Function     interleukin-6 receptor binding GO:0005138 IPI     leukemia inhibitory factor receptor activity GO:0004923 IDA     interleukin-6 binding GO:0019981 IPI     interleukin-11 binding GO:0019970 IEA     interleukin-27 receptor activity GO:0045509 IC     ciliary neurotrophic factor receptor activity GO:0004897 IDA     oncostatin-M receptor activity GO:0004924 IDA     protein homodimerization activity GO:0042803 TAS     interleukin-11 receptor activity GO:0004921 IEA     protein binding GO:0005515 IPI     interleukin-6 receptor activity GO:0004915 IDA     ciliary neurotrophic factor receptor binding GO:0005127 IPI     growth factor binding GO:0019838 IPI Biological Process     oncostatin-M-mediated signaling pathway GO:0038165 IMP     regulation of Notch signaling pathway GO:0008593 IEA     glycogen metabolic process GO:0005977 IEA     positive regulation of vascular endothelial growth factor production GO:0010575 TAS     positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 IMP     positive regulation of cell proliferation GO:0008284 IGI     response to cytokine GO:0034097 IDA     cytokine-mediated signaling pathway GO:0019221 IDA     interleukin-6-mediated signaling pathway GO:0070102 IMP     ciliary neurotrophic factor-mediated signaling pathway GO:0070120 IDA     interleukin-27-mediated signaling pathway GO:0070106 IMP     positive regulation of acute inflammatory response GO:0002675 IC     positive regulation of T cell proliferation GO:0042102 IMP     positive regulation of astrocyte differentiation GO:0048711 IEA     positive regulation of adaptive immune response GO:0002821 IC     viral process GO:0016032 IEA     negative regulation of apoptotic process GO:0043066 TAS     negative regulation of interleukin-6-mediated signaling pathway GO:0070104 IDA     positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 IMP     leukemia inhibitory factor signaling pathway GO:0048861 IDA     positive regulation of osteoblast differentiation GO:0045669 IMP     positive regulation of cardiac muscle hypertrophy GO:0010613 TAS     interleukin-11-mediated signaling pathway GO:0038154 IEA Subcellular Localization     interleukin-6 receptor complex GO:0005896 IDA     plasma membrane GO:0005886 TAS     neuronal cell body GO:0043025 IEA     dendrite GO:0030425 IEA     external side of plasma membrane GO:0009897 IEA     oncostatin-M receptor complex GO:0005900 IDA     extracellular exosome GO:0070062 IDA     membrane GO:0016020 IDA     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IDA     ciliary neurotrophic factor receptor complex GO:0070110 IDA