Gene description for TMEM200A
Gene name transmembrane protein 200A
Gene symbol TMEM200A
Other names/aliases KIAA1913
TTMA
TTMC
Species Homo sapiens
 Database cross references - TMEM200A
ExoCarta ExoCarta_114801
Vesiclepedia VP_114801
Entrez Gene 114801
HGNC 21075
UniProt Q86VY9  
 TMEM200A identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM200A
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified TMEM200A in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 1203
MISEV standards
EM
Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM200A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 AXL 558
Affinity Capture-MS Homo sapiens
3 PPP3CA 5530
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MYADM 91663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PPP3R1 5534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PCDHGA6 56109
Affinity Capture-MS Homo sapiens
7 STX10 8677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ERBB2 2064
Affinity Capture-MS Homo sapiens
9 TGFBR2 7048
Affinity Capture-MS Homo sapiens
10 PLEKHH3  
Affinity Capture-MS Homo sapiens
11 RHBDF2 79651
Affinity Capture-MS Homo sapiens
12 TP53 7157
Synthetic Growth Defect Homo sapiens
13 GOSR1 9527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 BMPR1A 657
Affinity Capture-MS Homo sapiens
15 NR3C1 2908
Proximity Label-MS Homo sapiens
16 TMEM9B 56674
Affinity Capture-MS Homo sapiens
17 EMD 2010
Two-hybrid Homo sapiens
18 PPP3R2  
Affinity Capture-MS Homo sapiens
19 IFNGR1 3459
Affinity Capture-MS Homo sapiens
20 FHOD1 29109
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 KCNE3  
Affinity Capture-MS Homo sapiens
22 ACVR1B 91
Affinity Capture-MS Homo sapiens
23 KLHDC8A  
Affinity Capture-MS Homo sapiens
24 INSRR 3645
Affinity Capture-MS Homo sapiens
25 DDR1 780
Affinity Capture-MS Homo sapiens
26 PPP3CB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 BSND  
Affinity Capture-MS Homo sapiens
28 STX6 10228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 UNC119 9094
Two-hybrid Homo sapiens
30 ERC1 23085
Cross-Linking-MS (XL-MS) Homo sapiens
31 OSMR 9180
Affinity Capture-MS Homo sapiens
32 SLC31A1 1317
Affinity Capture-MS Homo sapiens
33 PIGH  
Affinity Capture-MS Homo sapiens
34 C9orf91 203197
Affinity Capture-MS Homo sapiens
35 CAMK2G 818
Affinity Capture-MS Homo sapiens
36 BCL2L10  
Two-hybrid Homo sapiens
37 PPP3CC 5533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM200A is involved
No pathways found





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