Gene description for TIMP1
Gene name	TIMP metallopeptidase inhibitor 1
Gene symbol	TIMP1
Other names/aliases	CLGI EPA EPO HCI TIMP
Species	Homo sapiens
Database cross references - TIMP1
ExoCarta	ExoCarta_7076
Entrez Gene	7076
HGNC	11820
MIM	305370
UniProt	P01033
TIMP1 identified in exosomes derived from the following tissue/cell type
Keratinocytes	19530224
Keratinocytes	19530224
Mesenchymal stem cells	Unpublished / Not applicable
Nasopharyngeal carcinoma cells	25857718
Nasopharyngeal carcinoma cells	25857718
Nasopharyngeal carcinoma cells	25857718
Squamous carcinoma cells	20124223

Gene ontology annotations for TIMP1

Molecular Function     metalloendopeptidase inhibitor activity GO:0008191 IDA     cytokine activity GO:0005125 IDA     growth factor activity GO:0008083 IEA     protein binding GO:0005515 IPI     protease binding GO:0002020 IBA     metal ion binding GO:0046872 IEA Biological Process     extracellular matrix disassembly GO:0022617 TAS     response to cytokine GO:0034097 IBA     response to hormone GO:0009725 IBA     response to peptide hormone GO:0043434 IEA     aging GO:0007568 IEA     negative regulation of apoptotic process GO:0043066 IEA     regulation of integrin-mediated signaling pathway GO:2001044 IMP     negative regulation of membrane protein ectodomain proteolysis GO:0051045 IDA     platelet activation GO:0030168 TAS     positive regulation of cell proliferation GO:0008284 IDA     negative regulation of metalloenzyme activity GO:0048553 IDA     negative regulation of trophoblast cell migration GO:1901164 IMP     negative regulation of endopeptidase activity GO:0010951 IDA     platelet degranulation GO:0002576 TAS     extracellular matrix organization GO:0030198 TAS     blood coagulation GO:0007596 TAS Subcellular Localization     extracellular region GO:0005576 TAS     extracellular exosome GO:0070062 IDA     basement membrane GO:0005604 IEA     proteinaceous extracellular matrix GO:0005578 IBA     extracellular space GO:0005615 IDA     platelet alpha granule lumen GO:0031093 TAS