Gene description for EGF
Gene name	epidermal growth factor
Gene symbol	EGF
Other names/aliases	HOMG4 URG
Species	Homo sapiens
Database cross references - EGF
ExoCarta	ExoCarta_1950
Entrez Gene	1950
HGNC	3229
MIM	131530
UniProt	P01133
EGF identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Urine	15326289
Urine	19056867
Urine	21082674
Urine	21595033
Urine	21595033
Urine	21595033
Urine	22418980
Urine	22418980

Gene ontology annotations for EGF

Molecular Function     growth factor activity GO:0008083 IDA     transmembrane receptor protein tyrosine kinase activator activity GO:0030297 TAS     protein binding GO:0005515 IPI     calcium ion binding GO:0005509 IEA     epidermal growth factor receptor binding GO:0005154 TAS Biological Process     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     phosphatidylinositol-mediated signaling GO:0048015 TAS     innate immune response GO:0045087 TAS     positive regulation of cerebellar granule cell precursor proliferation GO:0021940 IEA     angiogenesis GO:0001525 IDA     blood coagulation GO:0007596 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 TAS     positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 IEA     positive regulation of DNA binding GO:0043388 ISS     positive regulation of hyaluronan biosynthetic process GO:1900127 IDA     negative regulation of cholesterol efflux GO:0090370 IEA     positive regulation of epidermal growth factor-activated receptor activity GO:0045741 TAS     ERK1 and ERK2 cascade GO:0070371 IDA     positive regulation of phosphorylation GO:0042327 IDA     positive regulation of peptidyl-threonine phosphorylation GO:0010800 IDA     positive regulation of catenin import into nucleus GO:0035413 IDA     negative regulation of secretion GO:0051048 IDA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     regulation of calcium ion import GO:0090279 IDA     activation of MAPKK activity GO:0000186 IEA     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 TAS     regulation of protein localization to cell surface GO:2000008 IDA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     platelet degranulation GO:0002576 TAS     peptidyl-tyrosine phosphorylation GO:0018108 IEA     positive regulation of cell proliferation GO:0008284 IDA     STAT protein import into nucleus GO:0007262 ISS     branching morphogenesis of an epithelial tube GO:0048754 IEA     positive regulation of mitotic nuclear division GO:0045840 IDA     positive regulation of MAP kinase activity GO:0043406 IDA     platelet activation GO:0030168 TAS     signal transduction GO:0007165 TAS     positive regulation of transcription, DNA-templated GO:0045893 IDA     DNA replication GO:0006260 TAS     mammary gland alveolus development GO:0060749 IEA Subcellular Localization     lysosomal membrane GO:0005765 IDA     plasma membrane GO:0005886 IEA     extracellular region GO:0005576 TAS     platelet alpha granule lumen GO:0031093 TAS     extracellular exosome GO:0070062 IDA     extracellular space GO:0005615 IDA     integral component of membrane GO:0016021 IEA