Gene description for LCP2
Gene name
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Gene symbol
LCP2
Other names/aliases
SLP-76 SLP76
Species
Homo sapiens
Database cross references - LCP2
ExoCarta
ExoCarta_3937
Entrez Gene
3937
HGNC
6529
MIM
601603
UniProt
Q13094
LCP2 identified in exosomes derived from the following tissue/cell type
Platelets
25332113
Platelets
25332113
Platelets
25332113
Gene ontology annotations for LCP2
Experiment description of studies that identified LCP2 in exosomes
1
Experiment ID
231
ISEV standards
✘
EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
2
Experiment ID
232
ISEV standards
✘
EV Biophysical techniques
✘
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
233
ISEV standards
✘
EV Biophysical techniques
✘
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for LCP2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
PLCG2
5336
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
2
FYB
2533
Invitro
Homo sapiens
3
GRAP2
9402
Invivo
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
Invitro
Homo sapiens
Reconstituted Complex
Homo sapiens
Two-hybrid
Homo sapiens
Affinity Capture-MS
Homo sapiens
4
TRAT1
50852
Reconstituted Complex
Homo sapiens
5
LYN
4067
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
6
ITK
3702
Invivo
Homo sapiens
Invitro
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
7
LAT
27040
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
8
SYK
6850
Affinity Capture-MS
Homo sapiens
9
VAV1
7409
Invivo
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
10
PRAM-1
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
11
NCK1
4690
Reconstituted Complex
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
12
PLCG1
5335
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
13
GRB2
2885
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
14
SHC1
6464
Affinity Capture-MS
Homo sapiens
15
PIK3R1
5295
Two-hybrid
Homo sapiens
Affinity Capture-Western
Homo sapiens
16
PTPRC
5788
Invivo
Homo sapiens
17
CBL
867
Invivo
Homo sapiens
18
PAG1
Reconstituted Complex
Homo sapiens
19
PTPN6
5777
Invitro
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-MS
Homo sapiens
20
SHB
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
21
WAS
7454
Invitro
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which LCP2 is involved