Gene description for TEC
Gene name tec protein tyrosine kinase
Gene symbol TEC
Other names/aliases PSCTK4
Species Homo sapiens
 Database cross references - TEC
ExoCarta ExoCarta_7006
Entrez Gene 7006
HGNC 11719
MIM 600583
UniProt P42680  
 TEC identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for TEC
Molecular Function
    protein binding GO:0005515 IPI
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    receptor binding GO:0005102 IBA
    phospholipid binding GO:0005543 NAS
Biological Process
    adaptive immune response GO:0002250 IBA
    cell differentiation GO:0030154 IBA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    regulation of cell proliferation GO:0042127 IBA
    B cell receptor signaling pathway GO:0050853 IDA
    peptidyl-tyrosine autophosphorylation GO:0038083 IMP
    tissue regeneration GO:0042246 IBA
    protein phosphorylation GO:0006468 TAS
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    intracellular signal transduction GO:0035556 IEA
    integrin-mediated signaling pathway GO:0007229 IDA
    T cell receptor signaling pathway GO:0050852 IBA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    regulation of platelet activation GO:0010543 IDA
    innate immune response GO:0045087 TAS
Subcellular Localization
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA
    cell-cell junction GO:0005911 IEA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IDA
 Experiment description of studies that identified TEC in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TEC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Affinity Capture-Western Homo sapiens
2 WAS 7454
Reconstituted Complex Homo sapiens
3 PRLR  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 VAV1 7409
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
5 DOK1 1796
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
6 RAC1 5879
Phenotypic Enhancement Homo sapiens
7 GNA12 2768
Invivo Homo sapiens
8 SOCS1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
9 JAK2 3717
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
10 JAK1 3716
Affinity Capture-Western Homo sapiens
11 KIT 3815
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 PIK3R2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TEC is involved
PathwayEvidenceSource
FCERI mediated Ca+2 mobilization TAS Reactome
Interleukin-3, 5 and GM-CSF signaling TAS Reactome
Signaling by SCF-KIT TAS Reactome





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