Gene description for INSR
Gene name	insulin receptor
Gene symbol	INSR
Other names/aliases	CD220 HHF5
Species	Homo sapiens
Database cross references - INSR
ExoCarta	ExoCarta_3643
Entrez Gene	3643
HGNC	6091
MIM	147670
UniProt	P06213
INSR identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Mesenchymal stem cells	Unpublished / Not applicable
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for INSR

Molecular Function     insulin-activated receptor activity GO:0005009 IDA     protein tyrosine kinase activity GO:0004713 IMP     insulin-like growth factor receptor binding GO:0005159 IDA     phosphatidylinositol 3-kinase binding GO:0043548 IPI     insulin-like growth factor II binding GO:0031995 IPI     GTP binding GO:0005525 IDA     insulin receptor substrate binding GO:0043560 IPI     insulin-like growth factor I binding GO:0031994 IPI     ATP binding GO:0005524 IDA     PTB domain binding GO:0051425 IPI     protein binding GO:0005515 IPI     insulin binding GO:0043559 IPI     receptor signaling protein tyrosine kinase activity GO:0004716 IDA Biological Process     male sex determination GO:0030238 IEA     epidermis development GO:0008544 IEA     positive regulation of mitotic nuclear division GO:0045840 IMP     positive regulation of glucose import GO:0046326 NAS     activation of protein kinase B activity GO:0032148 IDA     positive regulation of protein kinase B signaling GO:0051897 IMP     exocrine pancreas development GO:0031017 IEA     positive regulation of respiratory burst GO:0060267 IDA     regulation of transcription, DNA-templated GO:0006355 IMP     positive regulation of developmental growth GO:0048639 IMP     cellular response to growth factor stimulus GO:0071363 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 IMP     positive regulation of glycolytic process GO:0045821 IMP     positive regulation of cell proliferation GO:0008284 IDA     glucose homeostasis GO:0042593 IMP     positive regulation of MAPK cascade GO:0043410 IMP     insulin receptor signaling pathway GO:0008286 TAS     peptidyl-tyrosine autophosphorylation GO:0038083 IEA     activation of protein kinase activity GO:0032147 IMP     protein autophosphorylation GO:0046777 IMP     carbohydrate metabolic process GO:0005975 IEA     protein heterotetramerization GO:0051290 IDA     G-protein coupled receptor signaling pathway GO:0007186 IDA     regulation of embryonic development GO:0045995 IMP     positive regulation of DNA replication GO:0045740 IMP     signal transduction by protein phosphorylation GO:0023014 IDA     positive regulation of glycogen biosynthetic process GO:0045725 IDA     transformation of host cell by virus GO:0019087 IMP     cellular response to insulin stimulus GO:0032869 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     heart morphogenesis GO:0003007 IMP     positive regulation of protein phosphorylation GO:0001934 IDA     positive regulation of cell migration GO:0030335 IMP     activation of MAPK activity GO:0000187 IMP Subcellular Localization     caveola GO:0005901 IDA     extracellular exosome GO:0070062 IDA     receptor complex GO:0043235 IDA     membrane GO:0016020 IDA     plasma membrane GO:0005886 TAS     integral component of plasma membrane GO:0005887 IDA     intracellular membrane-bounded organelle GO:0043231 IDA     endosome membrane GO:0010008 TAS     insulin receptor complex GO:0005899 IMP