Gene description for NCK1
Gene name	NCK adaptor protein 1
Gene symbol	NCK1
Other names/aliases	NCK NCKalpha nck-1
Species	Homo sapiens
Database cross references - NCK1
ExoCarta	ExoCarta_4690
Entrez Gene	4690
HGNC	7664
MIM	600508
UniProt	P16333
NCK1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for NCK1

Molecular Function     protein binding, bridging GO:0030674 IC     cytoskeletal adaptor activity GO:0008093 NAS     protein binding GO:0005515 IPI     receptor binding GO:0005102 IPI     SH3/SH2 adaptor activity GO:0005070 NAS     protein kinase inhibitor activity GO:0004860 IDA     protein domain specific binding GO:0019904 IEA     receptor signaling complex scaffold activity GO:0030159 NAS     receptor tyrosine kinase binding GO:0030971 IPI     eukaryotic initiation factor eIF2 binding GO:0071074 IPI Biological Process     positive regulation of T cell proliferation GO:0042102 IMP     negative regulation of PERK-mediated unfolded protein response GO:1903898 IDA     axon guidance GO:0007411 TAS     signal complex assembly GO:0007172 NAS     negative regulation of protein kinase activity GO:0006469 IDA     negative regulation of cell death GO:0060548 IDA     T cell activation GO:0042110 IMP     small GTPase mediated signal transduction GO:0007264 TAS     substrate-dependent cell migration, cell extension GO:0006930 IEA     response to other organism GO:0051707 IEA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     actin filament organization GO:0007015 IEA     positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902237 IDA     negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation GO:1903912 IDA     T cell receptor signaling pathway GO:0050852 TAS     positive regulation of translation in response to endoplasmic reticulum stress GO:0036493 IDA     negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990441 IDA     innate immune response GO:0045087 TAS     positive regulation of actin filament polymerization GO:0030838 IMP     peptidyl-serine dephosphorylation GO:0070262 IDA     negative regulation of peptidyl-serine phosphorylation GO:0033137 IDA     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     positive regulation of cap-independent translational initiation GO:1903679 IDA     positive regulation of cap-dependent translational initiation GO:1903676 IDA     lamellipodium assembly GO:0030032 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA Subcellular Localization     cell-cell junction GO:0005911 IEA     vesicle membrane GO:0012506 IEA     protein phosphatase type 1 complex GO:0000164 IDA     nucleus GO:0005634 IEA     ribosome GO:0005840 IDA     endoplasmic reticulum GO:0005783 IDA     cytoplasm GO:0005737 NAS     cytosol GO:0005829 TAS     plasma membrane GO:0005886 TAS