Gene description for ITK
Gene name	IL2-inducible T-cell kinase
Gene symbol	ITK
Other names/aliases	EMT LPFS1 LYK PSCTK2
Species	Homo sapiens
Database cross references - ITK
ExoCarta	ExoCarta_3702
Vesiclepedia	VP_3702
Entrez Gene	3702
HGNC	6171
MIM	186973
UniProt	Q08881
ITK identified in sEVs derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for ITK

Molecular Function     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     histone H3Y41 kinase activity GO:0035401 IEA     metal ion binding GO:0046872 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     positive regulation of cytokine production GO:0001819 ISS     NK T cell differentiation GO:0001865 IBA     adaptive immune response GO:0002250 IBA     adaptive immune response GO:0002250 ISS     chromatin remodeling GO:0006338 IEA     cellular defense response GO:0006968 TAS     signal transduction GO:0007165 TAS     intracellular signal transduction GO:0035556 IEA     T cell activation GO:0042110 TAS     gamma-delta T cell activation GO:0046629 ISS     T cell receptor signaling pathway GO:0050852 IBA     T cell receptor signaling pathway GO:0050852 ISS     B cell receptor signaling pathway GO:0050853 IBA Subcellular Localization     nucleus GO:0005634 ISS     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     cell-cell junction GO:0005911 IEA