Gene description for ELF3
Gene name E74-like factor 3 (ets domain transcription factor, epithelial-specific )
Gene symbol ELF3
Other names/aliases EPR-1
Species Homo sapiens
 Database cross references - ELF3
ExoCarta ExoCarta_1999
Entrez Gene 1999
HGNC 3318
MIM 602191
UniProt P78545  
 ELF3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ELF3
Molecular Function
    protein binding GO:0005515 IPI
    transcription coactivator activity GO:0003713 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IEA
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IBA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
Biological Process
    blastocyst development GO:0001824 IEA
    extracellular matrix organization GO:0030198 IEA
    mammary gland involution GO:0060056 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    transcription from RNA polymerase II promoter GO:0006366 TAS
    inflammatory response GO:0006954 IEP
    epidermis development GO:0008544 NAS
    multicellular organismal development GO:0007275 TAS
    regulation of transcription from RNA polymerase II promoter GO:0006357 IBA
    epithelial cell differentiation GO:0030855 IEP
Subcellular Localization
    nucleus GO:0005634 NAS
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified ELF3 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ELF3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NFKB1 4790
Reconstituted Complex Homo sapiens
2 DDX3X 1654
Affinity Capture-MS Homo sapiens
3 MED23 9439
Invitro Homo sapiens
4 P4HB 5034
Affinity Capture-MS Homo sapiens
5 GANAB 23193
Affinity Capture-MS Homo sapiens
6 ISG15 9636
Affinity Capture-MS Homo sapiens
7 CALR 811
Affinity Capture-MS Homo sapiens
8 EPS15 2060
Invivo Homo sapiens
Two-hybrid Homo sapiens
9 EHF  
Affinity Capture-MS Homo sapiens
10 KRTHB2  
Affinity Capture-MS Homo sapiens
11 KRT31 3881
Affinity Capture-MS Homo sapiens
12 EEF1D 1936
Affinity Capture-MS Homo sapiens
13 JAK1 3716
Affinity Capture-MS Homo sapiens
14 ATIC 471
Affinity Capture-MS Homo sapiens
15 TARS 6897
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ELF3 is involved
No pathways found

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