Gene description for INSRR
Gene name insulin receptor-related receptor
Gene symbol INSRR
Other names/aliases IRR
Species Homo sapiens
 Database cross references - INSRR
ExoCarta ExoCarta_3645
Vesiclepedia VP_3645
Entrez Gene 3645
HGNC 6093
MIM 147671
UniProt P14616  
 INSRR identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for INSRR
Molecular Function
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 NAS
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IBA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    phosphatidylinositol 3-kinase binding GO:0043548 IEA
    insulin receptor substrate binding GO:0043560 IBA
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 NAS
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    actin cytoskeleton organization GO:0030036 IDA
    male sex determination GO:0030238 IEA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    protein autophosphorylation GO:0046777 IMP
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IEA
    cellular response to alkaline pH GO:0071469 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 NAS
    insulin receptor complex GO:0005899 IBA
    axon GO:0030424 IBA
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified INSRR in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for INSRR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASH2L 9070
Affinity Capture-MS Homo sapiens
2 AXL 558
Affinity Capture-MS Homo sapiens
3 DDR1 780
Affinity Capture-MS Homo sapiens
4 HMGCR  
Affinity Capture-MS Homo sapiens
5 PKMYT1  
Affinity Capture-MS Homo sapiens
6 PRKCD 5580
Affinity Capture-MS Homo sapiens
7 SETD1A 9739
Affinity Capture-MS Homo sapiens
8 ANKLE2 23141
Affinity Capture-MS Homo sapiens
9 TYW1  
Affinity Capture-MS Homo sapiens
10 ERBB2 2064
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
11 ACVR1 90
Affinity Capture-MS Homo sapiens
12 RHBDF2 79651
Affinity Capture-MS Homo sapiens
13 SLC27A4 10999
Affinity Capture-MS Homo sapiens
14 LEMD3  
Affinity Capture-MS Homo sapiens
15 CXXC1  
Affinity Capture-MS Homo sapiens
16 DEFB116  
Affinity Capture-MS Homo sapiens
17 MYADM 91663
Affinity Capture-MS Homo sapiens
18 RBBP5 5929
Affinity Capture-MS Homo sapiens
19 SREBF1 6720
Affinity Capture-MS Homo sapiens
20 CDC37 11140
Affinity Capture-MS Homo sapiens
21 PLCD3 113026
Affinity Capture-MS Homo sapiens
22 BMPR1A 657
Affinity Capture-MS Homo sapiens
23 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
24 INSR 3643
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
25 FKBP8 23770
Affinity Capture-MS Homo sapiens
26 HSP90AB3P 3327
Affinity Capture-MS Homo sapiens
27 IGF1R 3480
Affinity Capture-MS Homo sapiens
28 HSP90AA5P 730211
Affinity Capture-MS Homo sapiens
29 DCAKD 79877
Affinity Capture-MS Homo sapiens
30 TMEM200A 114801
Affinity Capture-MS Homo sapiens
31 MMGT1 93380
Affinity Capture-MS Homo sapiens
32 ZMYM3  
Affinity Capture-MS Homo sapiens
33 CYP51A1 1595
Affinity Capture-MS Homo sapiens
34 FKBP5 2289
Affinity Capture-MS Homo sapiens
35 IDH2 3418
Affinity Capture-MS Homo sapiens
36 CTDSP2 10106
Two-hybrid Homo sapiens
37 ACVR1B 91
Affinity Capture-MS Homo sapiens
38 JAK1 3716
Affinity Capture-MS Homo sapiens
39 PTPN1 5770
Affinity Capture-MS Homo sapiens
40 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
41 PRKCA 5578
Affinity Capture-MS Homo sapiens
42 RAB13 5872
Affinity Capture-MS Homo sapiens
43 CDKAL1  
Affinity Capture-MS Homo sapiens
44 OSBPL5 114879
Affinity Capture-MS Homo sapiens
45 VRK2 7444
Affinity Capture-MS Homo sapiens
46 OTULIN 90268
Affinity Capture-MS Homo sapiens
47 TAP1 6890
Affinity Capture-MS Homo sapiens
48 STYX  
Two-hybrid Homo sapiens
49 VASN 114990
Affinity Capture-MS Homo sapiens
50 VCPIP1 80124
Affinity Capture-MS Homo sapiens
51 OSBPL8 114882
Affinity Capture-MS Homo sapiens
52 ARHGEF40 55701
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which INSRR is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here