Gene description for NOP10
Gene name NOP10 ribonucleoprotein
Gene symbol NOP10
Other names/aliases DKCB1
NOLA3
NOP10P
Species Homo sapiens
 Database cross references - NOP10
ExoCarta ExoCarta_55505
Vesiclepedia VP_55505
Entrez Gene 55505
HGNC 14378
MIM 606471
UniProt Q9NPE3  
 NOP10 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for NOP10
Molecular Function
    RNA binding GO:0003723 IPI
    protein binding GO:0005515 IPI
    box H/ACA snoRNA binding GO:0034513 IPI
    telomerase RNA binding GO:0070034 IBA
    telomerase RNA binding GO:0070034 IPI
    telomerase RNA binding GO:0070034 TAS
Biological Process
    pseudouridine synthesis GO:0001522 NAS
    telomere maintenance via telomerase GO:0007004 IDA
    telomere maintenance via telomerase GO:0007004 NAS
    telomere maintenance via telomerase GO:0007004 TAS
    rRNA pseudouridine synthesis GO:0031118 IBA
    snRNA pseudouridine synthesis GO:0031120 IBA
    telomerase RNA localization to Cajal body GO:0090671 HMP
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    telomerase holoenzyme complex GO:0005697 IDA
    telomerase holoenzyme complex GO:0005697 NAS
    telomerase holoenzyme complex GO:0005697 TAS
    sno(s)RNA-containing ribonucleoprotein complex GO:0005732 TAS
    nuclear body GO:0016604 IDA
    box H/ACA snoRNP complex GO:0031429 IBA
    box H/ACA snoRNP complex GO:0031429 IDA
    box H/ACA snoRNP complex GO:0031429 TAS
    box H/ACA scaRNP complex GO:0072589 TAS
    box H/ACA telomerase RNP complex GO:0090661 IDA
    box H/ACA telomerase RNP complex GO:0090661 TAS
 Experiment description of studies that identified NOP10 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NOP10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK17 5128
Affinity Capture-MS Homo sapiens
2 TTC19  
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 YBX1 4904
Affinity Capture-MS Homo sapiens
5 FGFBP1 9982
Affinity Capture-MS Homo sapiens
6 NHP2 55651
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
7 WRAP53  
Affinity Capture-MS Homo sapiens
8 ARRB2 409
Affinity Capture-MS Homo sapiens
9 CABP2  
Two-hybrid Homo sapiens
10 MYCN  
Affinity Capture-MS Homo sapiens
11 RC3H1 149041
Affinity Capture-MS Homo sapiens
12 CARD9 64170
Affinity Capture-MS Homo sapiens
13 CTDSP1 58190
Affinity Capture-MS Homo sapiens
14 SOD1 6647
Affinity Capture-MS Homo sapiens
15 ZNF346  
Affinity Capture-MS Homo sapiens
16 KPNA1 3836
Affinity Capture-MS Homo sapiens
17 GAR1 54433
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RPL13 6137
Affinity Capture-MS Homo sapiens
19 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
20 LIN28A  
Affinity Capture-MS Homo sapiens
21 RC3H2  
Affinity Capture-MS Homo sapiens
22 ECT2 1894
Affinity Capture-MS Homo sapiens
23 SRSF6 6431
Affinity Capture-MS Homo sapiens
24 MNDA 4332
Affinity Capture-MS Homo sapiens
25 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
26 BTF3 689
Affinity Capture-MS Homo sapiens
27 USP36  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
28 SRSF1 6426
Affinity Capture-MS Homo sapiens
29 SUB1 10923
Affinity Capture-MS Homo sapiens
30 LMNB2 84823
Affinity Capture-MS Homo sapiens
31 NOP56 10528
Affinity Capture-MS Homo sapiens
32 NPM3 10360
Affinity Capture-MS Homo sapiens
33 RPS19 6223
Affinity Capture-MS Homo sapiens
34 RPL10 6134
Affinity Capture-MS Homo sapiens
35 BCHE 590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LIN28B  
Affinity Capture-MS Homo sapiens
37 SHQ1  
Affinity Capture-MS Homo sapiens
38 EGFR 1956
Negative Genetic Homo sapiens
39 HSD17B10 3028
Affinity Capture-MS Homo sapiens
40 COIL  
Affinity Capture-MS Homo sapiens
41 H2AFB3  
Affinity Capture-MS Homo sapiens
42 NAF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 Ppp4c 56420
Affinity Capture-MS Mus musculus
44 YBX2 51087
Affinity Capture-MS Homo sapiens
45 RPL3 6122
Affinity Capture-MS Homo sapiens
46 PURG  
Affinity Capture-MS Homo sapiens
47 XPO1 7514
Affinity Capture-MS Homo sapiens
48 KRR1 11103
Affinity Capture-MS Homo sapiens
49 WDR48 57599
Affinity Capture-MS Homo sapiens
50 RSRC1  
Affinity Capture-MS Homo sapiens
51 Srp72  
Affinity Capture-MS Mus musculus
52 MYC  
Affinity Capture-MS Homo sapiens
53 AURKA 6790
Affinity Capture-MS Homo sapiens
54 RPSA 3921
Affinity Capture-MS Homo sapiens
55 SNRNP70 6625
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ARRB1 408
Affinity Capture-MS Homo sapiens
57 DLST 1743
Affinity Capture-MS Homo sapiens
58 Rrbp1  
Affinity Capture-MS Mus musculus
59 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
60 DKC1 1736
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MEOX2  
Two-hybrid Homo sapiens
62 PRC1 9055
Affinity Capture-MS Homo sapiens
63 KRAS 3845
Negative Genetic Homo sapiens
64 BMI1  
Affinity Capture-MS Homo sapiens
65 DCAF4  
Affinity Capture-MS Homo sapiens
66 RPL36AL 6166
Affinity Capture-MS Homo sapiens
67 RBM34  
Affinity Capture-MS Homo sapiens
68 DDX58 23586
Affinity Capture-RNA Homo sapiens
69 SRPK3  
Affinity Capture-MS Homo sapiens
70 MAGEB2 4113
Affinity Capture-MS Homo sapiens
71 ZC3H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
73 PRKRA 8575
Affinity Capture-MS Homo sapiens
74 UBE2H 7328
Affinity Capture-MS Homo sapiens
75 Nhp2l1 20826
Affinity Capture-MS Mus musculus
76 CRNN 49860
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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